Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Samuel P. Hoile"'
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189655 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0134664.].
Externí odkaz:
https://doaj.org/article/409a6bfa2b7a4b7aad9bd1cdd138c42c
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134664 (2015)
Environmental challenges such as a high fat diet during pregnancy can induce changes in offspring growth, metabolism and cardiovascular function. However, challenges that are sustained over several generations can induce progressive compensatory meta
Externí odkaz:
https://doaj.org/article/c2a1b67857ab481aafa4b7f3b4947e3a
Autor:
Samuel P Hoile, Rebecca Clarke-Harris, Rae-Chi Huang, Philip C Calder, Trevor A Mori, Lawrence J Beilin, Karen A Lillycrop, Graham C Burdge
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109896 (2014)
BACKGROUND: Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulati
Externí odkaz:
https://doaj.org/article/ddf7ca4d96a74467b8edaf82bce9a49d
Autor:
Christopher J Kelsall, Samuel P Hoile, Nicola A Irvine, Mojgan Masoodi, Christopher Torrens, Karen A Lillycrop, Philip C Calder, Geraldine F Clough, Mark A Hanson, Graham C Burdge
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34492 (2012)
Nutrition during development affects risk of future cardiovascular disease. Relatively little is known about whether the amount and type of fat in the maternal diet affect vascular function in the offspring. To investigate this, pregnant and lactatin
Externí odkaz:
https://doaj.org/article/a0c577fd1fc54c9184075dc376e5c946
Autor:
Graham C Burdge, Samuel P Hoile, Tobias Uller, Nicola A Thomas, Peter D Gluckman, Mark A Hanson, Karen A Lillycrop
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28282 (2011)
Induction of altered phenotypes during development in response to environmental input involves epigenetic changes. Phenotypic traits can be passed between generations by a variety of mechanisms, including direct transmission of epigenetic states or b
Externí odkaz:
https://doaj.org/article/613b9b6dc8ed490b98b01b78106c67bf
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21668 (2011)
There is considerable evidence for non-genomic transmission between generations of phenotypes induced by environmental exposures during development, although the mechanism is poorly understood. We investigated whether alterations in expression of the
Externí odkaz:
https://doaj.org/article/b890200c793943f58e520c22c82a707e
Autor:
Annette L. West, Christopher D. Byrne, Geraldine F. Clough, Keith McCormick, Eleonora Scorletti, Graham C. Burdge, Samuel P. Hoile, Philip C. Calder, Karen A. Lillycrop, Lokpal Bhatia
Publikováno v:
Journal of Hepatology. 63:1476-1483
Background & Aims Genetic variation in both patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) influences severity of liver disease, and serum triglyceride con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f039803d66326876efa3191a579e1f
https://doi.org/10.1016/j.jhep.2015.07.036
https://doi.org/10.1016/j.jhep.2015.07.036
Publikováno v:
Proceedings of the Nutrition Society. 73:413-421
It is well established that genotype plays an important role in the ageing process. However, recent studies have suggested that epigenetic mechanisms may also influence the onset of ageing-associated diseases and longevity. Epigenetics is defined as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b078c43520d9ecf8da563a47f9c238d
https://doi.org/10.1017/s0029665114000081
https://doi.org/10.1017/s0029665114000081
Publikováno v:
Current Opinion in Clinical Nutrition and Metabolic Care. 15:442-447
This review critically evaluates recent advances in understanding the role of epigenetics in nutrition. Findings from animal models and human cohorts are discussed in the context of whether or not epigenetics may be an important factor in the progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c6ec5b98381737c21e4a26c5259498
https://doi.org/10.1097/mco.0b013e3283567dd2
https://doi.org/10.1097/mco.0b013e3283567dd2
Publikováno v:
Oléagineux, Corps gras, Lipides, Vol 18, Iss 5, Pp 259-262 (2011)
The essential n-3 fatty acid α-linolenic acid (ALA) can be converted into eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) under the action of desaturase and elongase enzymes. Human studies have demonstrated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2267933752e170b211591c614ee2149
https://doi.org/10.1051/ocl.2011.0391
https://doi.org/10.1051/ocl.2011.0391