Výsledky vyhledávání - "Samuel P. Black"

Akademický článek

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

Autor: Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs

Externí odkaz: https://doaj.org/article/093c0d5069da4980a49ad192ca552eb0

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Akademický článek

Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells.

Autor: Deborah Frenkel, Fengqiu Zhang, Patrick Guirnalda, Carole Haynes, Viki Bockstal, Magdalena Radwanska, Stefan Magez, Samuel J Black

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005733 (2016)

After infection with T. brucei AnTat 1.1, C57BL/6 mice lost splenic B2 B cells and lymphoid follicles, developed poor parasite-specific antibody responses, lost weight, became anemic and died with fulminating parasitemia within 35 days. In contrast,

Externí odkaz: https://doaj.org/article/38d00a7effd346d4abadf5bdc0593cb1

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Akademický článek

An in vitro model of the horse gut microbiome enables identification of lactate-utilizing bacteria that differentially respond to starch induction.

Autor: Amy S Biddle, Samuel J Black, Jeffrey L Blanchard

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77599 (2013)

Laminitis is a chronic, crippling disease triggered by the sudden influx of dietary starch. Starch reaches the hindgut resulting in enrichment of lactic acid bacteria, lactate accumulation, and acidification of the gut contents. Bacterial products en

Externí odkaz: https://doaj.org/article/a1e9bd3b30c240158f6d2814df0e8c62

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Akademický článek

Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae.

Autor: Le Wang, Erica A Pawlak, Philip J Johnson, James K Belknap, Susan Eades, Sharon Stack, Helene Cousin, Samuel J Black

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56025 (2013)

The digital laminae is a two layer tissue that attaches the distal phalanx to the inner hoof wall, thus suspending the horse's axial skeleton in the hoof capsule. This tissue fails at the epidermal:dermal junction in laminitic horses, causing crippli

Externí odkaz: https://doaj.org/article/4517008bf8f648f19401cd806a89f21f

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Akademický článek

T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.

Autor: Viki Bockstal, Patrick Guirnalda, Guy Caljon, Radhika Goenka, Janice C Telfer, Deborah Frenkel, Magdalena Radwanska, Stefan Magez, Samuel J Black

Publikováno v: PLoS Pathogens, Vol 7, Iss 6, p e1002089 (2011)

African trypanosomes of the Trypanosoma brucei species are extracellular protozoan parasites that cause the deadly disease African trypanosomiasis in humans and contribute to the animal counterpart, Nagana. Trypanosome clearance from the bloodstream

Externí odkaz: https://doaj.org/article/328a79fea2374c5085f29ee6aef9c0a7

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