Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samuel O. Odutola"'
Autor:
Li Liu, Regan Schuetze, Jeni L. Gerberich, Ramona Lopez, Samuel O. Odutola, Rajendra P. Tanpure, Amanda K. Charlton-Sevcik, Justin K. Tidmore, Emily A.-S. Taylor, Payal Kapur, Hans Hammers, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason
Publikováno v:
Cancers, Vol 14, Iss 17, p 4208 (2022)
The vascular disrupting activity of a promising tubulin-binding agent (OXi6196) was demonstrated in mice in MDA-MB-231 human breast tumor xenografts growing orthotopically in mammary fat pad and syngeneic RENCA kidney tumors growing orthotopically in
Externí odkaz:
https://doaj.org/article/eb0eb219ccb242929d8a41e386e3c125
Autor:
Yihang Guo, Honghong Wang, Jeni L. Gerberich, Samuel O. Odutola, Amanda K. Charlton-Sevcik, Maoping Li, Rajendra P. Tanpure, Justin K. Tidmore, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Li Liu
Publikováno v:
Cancers, Vol 13, Iss 19, p 4769 (2021)
The selective disruption of tumor-associated vasculature represents an attractive therapeutic approach. We have undertaken the first in vivo evaluation of KGP265, a water-soluble prodrug of a benzosuberene-based tubulin-binding agent, and found promi
Externí odkaz:
https://doaj.org/article/a6beb499478a4c8b8563f6fe4fc89416
Autor:
Ralph P. Mason, Jeni Gerberich, Yihang Guo, Honghong Wang, Li Liu, Amanda K. Charlton-Sevcik, Justin K. Tidmore, Maoping Li, Samuel O. Odutola, Kevin G. Pinney, Mary Lynn Trawick, Rajendra P. Tanpure
Publikováno v:
Cancers
Volume 13
Issue 19
Cancers, Vol 13, Iss 4769, p 4769 (2021)
Volume 13
Issue 19
Cancers, Vol 13, Iss 4769, p 4769 (2021)
Simple Summary Vascular-disrupting agents promise significant therapeutic efficacy against solid tumors by selectively damaging tumor-associated vasculature. Dynamic BLI and oxygen-enhanced multispectral optoacoustic tomography (OE-MSOT) were used to
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 370:427-435
The Ca2+-sensing receptor (CaSR) detects small changes in extracellular calcium (Ca2+e) concentration ([Ca2+]e) and transduces the signal into modulation of various signaling pathways. Ca2+-induced relaxation of isolated phenylephrine-contracted mese
Autor:
Yifan Wang, Samuel O. Odutola, Zhe Shi, Erica Parker, Rajeswari Mukherjee, Kevin G. Pinney, David J. Chaplin, Mary Lynn Trawick, Tracy E. Strecker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1304-1310
The magnitude of expression of cathepsin L, often upregulated in the tumor microenvironment, correlates with the invasive and metastatic nature of certain tumors. Inhibition of cathepsin L represents an emerging strategy for the treatment of metastat
Publikováno v:
Hypertension. 74
The G protein-coupled Ca 2+ -Sensing Receptor (CaSR) mediates extracellular calcium (Ca 2+ e ) - induced relaxation of mesenteric arteries under tension and may therefore play a role in blood pressure regulation. This presents CaSR as promising targe
Publikováno v:
J Pharmacol Exp Ther
The Ca(2+)-sensing receptor (CaSR) detects small changes in extracellular calcium (Ca(2+)(e)) concentration ([Ca(2+)](e)) and transduces the signal into modulation of various signaling pathways. Ca(2+)-induced relaxation of isolated phenylephrine-con
Autor:
Samuel O. Odutola, Emmanuel M. Awumey
Publikováno v:
The FASEB Journal. 33
The G protein-coupled Ca2+-sensing receptor (CaSR) provides the primary mechanism for Ca2+e-mediated regulation of the release of parathyroid hormone (PTH) as a result of parathyroid cells sensing ...
Autor:
Gustavo E. Chavarria, Dietmar W. Siemann, David J. Chaplin, Erica Parker, Kevin G. Pinney, Ashleigh L. Barnes, Samuel O. Odutola, G.D. Kishore Kumar, Mary Lynn Trawick, Dhivya R. Sudhan, Amanda K. Charlton-Sevcik, Michael R. Horsman, Thomas Wittenborn, Jiangli Song, Tracy E. Strecker
Publikováno v:
Parker, E N, Song, J, Kishore Kumar, G D, Odutola, S O, Chavarria, G E, Charlton-Sevcik, A K, Strecker, T E, Barnes, A L, Sudhan, D R, Wittenborn, T R, Siemann, D W, Horsman, M R, Chaplin, D J, Trawick, M L & Pinney, K G 2015, ' Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L ', Bioorganic & Medicinal Chemistry, vol. 23, no. 21, pp. 6974-6992 . https://doi.org/10.1016/j.bmc.2015.09.036
Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti-met
Autor:
Anjan Ghatak, Ralph P. Mason, Li Liu, Tracy E. Strecker, Justin K. Tidmore, David J. Chaplin, Matthew T. MacDonough, Samuel O. Odutola, Li Li, Ramona Lopez, Morgan S. Cooper, Kevin G. Pinney, Mallinath B. Hadimani, Mary Lynn Trawick, Amanda K. Charlton-Sevcik
Publikováno v:
Cancer letters. 369(1)
This study describes the vascular disrupting ability and the mechanism of action of the indole-based tubulin-binding compound, OXi8006, and its water-soluble phosphate prodrug OXi8007. Treatment of rapidly proliferating human umbilical vein endotheli