Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Samuel O. Nortey"'
Autor:
Bruce E. Maryanoff, Allen B. Reitz, James J. McNally, Samuel O. Nortey, Pauline J. Sanfilippo, Richard P. Shank, Barry Dubinsky, David F. McComsey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1547-1552
A variety of pyrido[1,2-a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-f
Autor:
Richard P. Shank, Michael J. Costanzo, Samuel O. Nortey, Jeffry L. Vaught, Marta P. Ortegon, Michael N. Greco, Bruce E. Maryanoff, James J. Schupsky
Publikováno v:
Journal of Medicinal Chemistry. 41:1315-1343
We have explored the structure-activity relationship (SAR) surrounding the clinically efficacious antiepileptic drug topiramate (1), a unique sugar sulfamate anticonvulsant that was discovered in our laboratories. Systematic structural modification o
Publikováno v:
Tetrahedron Letters. 39:975-978
The arylsulfonate ester functionality connecting an alkyl chain to a polystyrene resin is cleaved with neat volatile primary or secondary amines to give secondary or tertiary amines, respectively, in high yields and purity. Non-volatile secondary ami
Publikováno v:
Tetrahedron Letters. 39:979-982
The arylsulfonate ester functionality connecting an alkyl chain to a polystyrene resin is compatible with Grignard additions, stabilized Wittig, sodium borohydride reduction, reductive aminations, acylations and addition of various electrophiles, and
Publikováno v:
Carbohydrate Research. 304:29-38
To corroborate the structures of two monohydroxylated metabolites of topiramate (1), we synthesized four monosaccharide derivatives from D-fructose: 4,5-O-[(1R)- and 4,5-O-[(1S)-1-hydroxymethylethylidene]-2,3-O-isopropylidene-beta-D -fructopyranose s
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1741-1743
Piperazinyl benzamidines were prepared and found to bind to the rat delta (δ) opioid receptor. The most active compounds had a N,N -diethylcarboxamido group and a N -benzyl piperazine. The most potent among these was N,N -diethyl-4-[4-(phenylmethyl)
Autor:
J. L. Vaught, Samuel O. Nortey, Richard P. Shank, David F. McComsey, Bruce E. Maryanoff, M. J. Costanzo
Publikováno v:
ChemInform. 22
Autor:
David F. McComsey, Pauline J. Sanfilippo, Allen B. Reitz, James J. McNally, Bruce E. Maryanoff, Barry Dubinsky, Richard P. Shank, Samuel O. Nortey
Publikováno v:
ChemInform. 30
Publikováno v:
ChemInform. 32
Piperazinyl benzamidines were prepared and found to bind to the rat delta (δ) opioid receptor. The most active compounds had a N,N -diethylcarboxamido group and a N -benzyl piperazine. The most potent among these was N,N -diethyl-4-[4-(phenylmethyl)
Autor:
Bruce E. Maryanoff, Michael J. Costanzo, David F. McComsey, Jeffry L. Vaught, Samuel O. Nortey, Richard P. Shank
Publikováno v:
Journal of Medicinal Chemistry. 33:2793-2797
A collection of hexahydropyrroloisoquinoline derivatives (1-22), which represent a class of compounds that inhibit the neuronal uptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), was investigated in vivo for serotonin-potentiating pr