Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Samuel O. Kyeremateng"'
Autor:
Georgios S. E. Antipas, Regina Reul, Kristin Voges, Samuel O. Kyeremateng, Nikolaos A. Ntallis, Konstantinos T. Karalis, Lukasz Miroslaw
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract We applied computing-as-a-service to the unattended system-agnostic miscibility prediction of the pharmaceutical surfactants, Vitamin E TPGS and Tween 80, with Copovidone VA64 polymer at temperature relevant for the pharmaceutical hot melt e
Externí odkaz:
https://doaj.org/article/ebb3bc60dddf4410a21bada1ce4336df
Autor:
Stefanie Walter, Paulo G. M. Mileo, Mohammad Atif Faiz Afzal, Samuel O. Kyeremateng, Matthias Degenhardt, Andrea R. Browning, John C. Shelley
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1292 (2024)
Background: During the dissolution of amorphous solid dispersion (ASD) formulations, the drug load (DL) often impacts the release mechanism and the occurrence of loss of release (LoR). The ASD/water interfacial gel layer and its specific phase behavi
Externí odkaz:
https://doaj.org/article/5bb5011965cf44d5888487f388d49294
Autor:
Adrian Krummnow, Andreas Danzer, Kristin Voges, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1395 (2023)
The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is commonly known as amorphous solid dispersion (ASD). API crystallization and/or amorphous phase
Externí odkaz:
https://doaj.org/article/bb69911e81364571a3da478b65b7215f
Autor:
Stefanie Dohrn, Samuel O. Kyeremateng, Esther Bochmann, Ekaterina Sobich, Andrea Wahl, Bernd Liepold, Gabriele Sadowski, Matthias Degenhardt
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1539 (2023)
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several
Externí odkaz:
https://doaj.org/article/4eefd122b7c543d780b5ac5709502bac
Autor:
Stefanie Dohrn, Pranay Rawal, Christian Luebbert, Kristin Lehmkemper, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100072- (2021)
Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of process parameters. Following the quality-by-design approach, the identification of the spray
Externí odkaz:
https://doaj.org/article/caf668c3cf8d4780b4a5c4dead240ad5
Autor:
Adrian Krummnow, Andreas Danzer, Kristin Voges, Stefanie Dohrn, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1904 (2022)
In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is dissolved on a molecular level in a polymeric matrix. The API is expected to be released from the ASD upon dissolution in aqueous media. However, a series of earlier
Externí odkaz:
https://doaj.org/article/a6f4f826bd9d43f4a239692d5477d985
Autor:
Samuel O. Kyeremateng, Kristin Voges, Stefanie Dohrn, Ekaterina Sobich, Ute Lander, Stefan Weber, David Gessner, Rachel C. Evans, Matthias Degenhardt
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1044 (2022)
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via th
Externí odkaz:
https://doaj.org/article/9cf670a5204d4d39a9ab4207bbe3564f
Publikováno v:
Polymers, Vol 14, Iss 5, p 998 (2022)
Poly(butyl cyanoacrylate) (PBCA) is a biodegradable and biocompatible homopolymer which is used as a carrier matrix for drug delivery systems in the pharmaceutical industry. Typically, polymerization is carried out under aqueous conditions and result
Externí odkaz:
https://doaj.org/article/f334e869a21c4bb4a183b67b23fd1340
Autor:
Mohammad Atif Faiz Afzal, Kristin Lehmkemper, Matthias Degenhardt, Paul Winget, Ekaterina Sobich, Thomas F. Hughes, Caroline M. Krauter, Samuel O. Kyeremateng, John C. Shelley, Teng Zhang, David J. Giesen, Andrea R. Browning
Publikováno v:
Molecular Pharmaceutics. 18:3999-4014
Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form which are dispersed in a hydrophilic polymer matrix. Producing a high-perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d33c82de6bd0c21c13f21e59450924
https://doi.org/10.1021/acs.molpharmaceut.1c00289
https://doi.org/10.1021/acs.molpharmaceut.1c00289
Autor:
Matthias Degenhardt, Christian Luebbert, Stefanie Dohrn, Samuel O. Kyeremateng, Kristin Lehmkemper, Gabriele Sadowski
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 158:132-142
Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for their successful approval for market. ASD stability does not only depend on the interplay between the active pharmaceutical ingredient (API) and the polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f41013a658a3133cba4752ffb1809d
https://doi.org/10.1016/j.ejpb.2020.11.002
https://doi.org/10.1016/j.ejpb.2020.11.002