Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samuel N. Baldwin"'
Autor:
Samuel N. Baldwin, Shaun L. Sandow, Gema Mondéjar-Parreño, Jennifer B. Stott, Iain A. Greenwood
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co
Externí odkaz:
https://doaj.org/article/bd48e0b6c26a464081470627100df2e6
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTSex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular b
Externí odkaz:
https://doaj.org/article/e3d2946695fb406ca0bef69126861b6a
Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Publikováno v:
Baldwin, S N, Jepps, T A & Greenwood, I A 2023, ' Cycling matters : Sex hormone regulation of vascular potassium channels ', Channels, vol. 17, no. 1, 2217637 . https://doi.org/10.1080/19336950.2023.2217637
Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dda8a06ca0fa93a0fd030f4411397e7
https://curis.ku.dk/portal/da/publications/cycling-matters(ac35ed53-1904-4c2e-993f-751185445224).html
https://curis.ku.dk/portal/da/publications/cycling-matters(ac35ed53-1904-4c2e-993f-751185445224).html
Autor:
Samuel N. Baldwin, Elizabeth A. Forrester, Natalie Z. M. Homer, Ruth Andrew, Vincenzo Barrese, Jennifer B. Stott, Brant E. Isakson, Anthony P. Albert, Iain A. Greenwood
Publikováno v:
Baldwin, S N, Forrester, E A, Homer, N Z M, Andrew, R, Barrese, V, Stott, J B, Isakson, B E, Albert, A P & Greenwood, I A 2022, ' Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1 ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15947
Background and purposeKcnq-encoded KV7 channels (termed KV7.1-5) regulate vascular smooth muscle cell (VSMC) contractility at rest and as downstream targets of receptor mediated responses. However, the current literature focuses predominantly on male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e0759f0cd9255b04c25a24fb956c0a
https://www.pure.ed.ac.uk/ws/files/313271074/British_J_Pharmacology_2022_Baldwin_Marked_oestrous_cycle_dependent_regulation_of_rat_arterial_KV7_4_channels_driven.pdf
https://www.pure.ed.ac.uk/ws/files/313271074/British_J_Pharmacology_2022_Baldwin_Marked_oestrous_cycle_dependent_regulation_of_rat_arterial_KV7_4_channels_driven.pdf
Autor:
Samuel N, Baldwin, Elizabeth A, Forrester, Natalie Z M, Homer, Ruth, Andrew, Vincenzo, Barrese, Jennifer B, Stott, Brant E, Isakson, Anthony P, Albert, Iain A, Greenwood
Publikováno v:
British journal of pharmacologyREFERENCES.
Kcnq-encoded KRT-qPCR, immunocytochemistry, proximity ligation assay and wire myography were performed in renal and mesenteric arteries. Circulating sex hormone concentrations were determined by liquid chromatography-tandem mass spectrometry. Whole-c
Publikováno v:
British journal of pharmacology. 179(7)
Prostacyclin mimetics express potent vasoactive effects via prostanoid receptors that are not unequivocally defined, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of IP and EPWithin second
Autor:
Henry R. Askew Page, Samuel N. Baldwin, Onur Cil, Alan S. Verkman, Kenneth P. Roos, Pyone Myat Thwe, Peter M. Haggie, Iain A. Greenwood, Marc O. Anderson, Maria C. Jordan, Xiaolan Chen
Publikováno v:
Kidney international, vol 100, iss 2
Kidney Int
Kidney Int
Hypertension is a major cause of cardiovascular morbidity and mortality, despite the availability of antihypertensive drugs with different targets and mechanisms of action. Here, we provide evidence that pharmacological inhibition of TMEM16A (ANO1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf8826a854b2a42c909c572d902841a
https://escholarship.org/uc/item/0q2931m3
https://escholarship.org/uc/item/0q2931m3
Autor:
Jennifer B. Stott, Iain A. Greenwood, Gema Mondejar-Parreño, Samuel N. Baldwin, Shaun L. Sandow
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11551913620248303a9c6b0cfa07ec9a
Autor:
Onur Cil, Maria C. Jordan, Pyone Myat Thwe, Iain A. Greenwood, Marc O. Anderson, Henry R. Askew Page, Kenneth P. Roos, Samuel N. Baldwin, Alan S. Verkman
Publikováno v:
Hypertension. 76
Hypertension is a major cause of cardiovascular morbidity and mortality, despite the availability of antihypertensive drugs with different targets and mechanisms of action. There is an unmet need for antihypertensive drugs with novel mechanisms of ac