Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Samuel Miller-Gutierrez"'
Autor:
Yana Roka-Moiia, Kaitlyn Ammann, Samuel Miller-Gutierrez, Jawaad Sheriff, Danny Bluestein, Joseph E. Italiano, Robert C. Flaumenhaft, Marvin J. Slepian
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7386
bioRxiv
bioRxiv
ObjectiveImplantable cardiovascular therapeutic devices (CTD) including stents, percutaneous heart valves and ventricular assist devices, while lifesaving, impart supraphysiologic shear stress to platelets resulting in thrombotic and bleeding device-
Autor:
Marvin J. Slepian, Samuel Miller-Gutierrez, Jawaad Sheriff, Yana Roka-Moiia, Joseph E. Italiano, Daniel E. Palomares, Danny Bluestein
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Mechanical circulatory support has emerged as lifesaving therapy for patients with advanced heart failure. However, mechanical circulatory support remains limited by a paradoxical coagulopathy accompanied by both thrombosis and bleeding. W
Autor:
Danny Bluestein, Marvin J. Slepian, Jawaad Sheriff, Yana Roka-Moiia, Kaitlyn R. Ammann, Joseph E. Italiano, Daniel E. Palomares, Samuel Miller-Gutierrez, Alice Sweedo
Publikováno v:
J Biomech
Shear-mediated platelet activation (SMPA) in the "free flow" is the net result of a range of cell mechanobiological mechanisms. Previously, we outlined three main groups of mechanisms including: 1) mechano-destruction - i.e. additive platelet (membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04efd5f34e4e94bf4bb81bfaf02042b1
https://europepmc.org/articles/PMC8513575/
https://europepmc.org/articles/PMC8513575/
Publikováno v:
ASAIO Journal. 68:47-47
Publikováno v:
ASAIO Journal. 68:45-45
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S179
Purpose Bleeding is a leading cause of readmission and 1-year mortality for mechanical circulatory support (MCS) patients. Mechanical damage of platelets and coagulation proteins induced by MCS-generated high shear stress is the main driver of bleedi