Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Samuel Mathieu"'
Autor:
Louis-Hippolyte Minvielle Moncla, Mewen Briend, Mame Sokhna Sylla, Samuel Mathieu, Anne Rufiange, Yohan Bossé, Patrick Mathieu
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-15 (2024)
Abstract Background Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that M
Externí odkaz:
https://doaj.org/article/ae65eb5cd17a41fb9304cc909e7de50f
Autor:
Alicia Ruiz-Rodrigo, Ernesto Morales, Maryem Lakoud, Jonathan Riendeau, Miranda Lemay, Ariane Savaria, Samuel Mathieu, Isabelle Feillou, François Routhier
Publikováno v:
Frontiers in Rehabilitation Sciences, Vol 5 (2024)
IntroductionAround 16% of world's population lives with visible and invisible disabilities. People with disabilities' participation may be limited because of the environmental obstacles. Moreover, historic heritage places were built before the develo
Externí odkaz:
https://doaj.org/article/3110a8d984cd457c8f8ae907c6fddd84
Autor:
Mewen Briend, Anne Rufiange, Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Yohan Bossé, Patrick Mathieu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Evidence indicates that enhancers are transcriptionally active. Herein, we investigated transcriptionally active enhancers by using cap analysis of gene expression (CAGE) combined with epigenetic marks and chromatin interactions. We identifi
Externí odkaz:
https://doaj.org/article/f7647932a7694a65acccb1f40bccd0a1
Autor:
Pauline Labbé, Victoria Munoz Goyette, Nathalie Thorin-Trescases, Louis Villeneuve, Ines Desanlis, Constance Delwarde, Yan-Fen Shi, Cécile Martel, Carol Yu, Azadeh Alikashani, Maya Mamarbachi, Frédéric Lesage, Samuel Mathieu, Jean-Claude Tardif, Patrick Mathieu, Marie Kmita, Éric Thorin
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Mice knockdown for Angiopoietin-like 2 (Angptl2) exhibit spontaneous aortic valve stenosis associated with a decrease in Notch signalling and an imbalance in cell apoptosis, senescence and proliferation during embryonic valve remodelling stage.
Externí odkaz:
https://doaj.org/article/d3d098d507604c479c8a3cf1d9dd3fe2
Autor:
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide gen
Externí odkaz:
https://doaj.org/article/40ff65e02a6640889ea700a7aabc850e
Autor:
Arnaud Chignon, Samuel Mathieu, Anne Rufiange, Déborah Argaud, Pierre Voisine, Yohan Bossé, Benoit J. Arsenault, Sébastien Thériault, Patrick Mathieu
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-17 (2022)
Abstract Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression qua
Externí odkaz:
https://doaj.org/article/59cd3c5154c147f89fff974ce254a412
Autor:
Samuel Mathieu, Mewen Briend, Erik Abner, Christian Couture, Zhonglin Li, Yohan Bossé, Sébastien Thériault, Tõnu Esko, Benoit J. Arsenault, Patrick Mathieu
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104992- (2022)
Summary: We carried out a genome-wide association analysis including 51,194 cases of hypothyroidism and 443,383 controls. In total, 139 risk loci were associated to hypothyroidism with genes involved in lymphocyte function. Candidate genes associated
Externí odkaz:
https://doaj.org/article/69eaa65584564c7b8d4f3a4dc8e2f5d5
Autor:
Patrick Mathieu, Anne Rufiange, Yohan Bossé, Deborah Argaud, Pierre Voisine, B. Arsenault, Sébastien Thériault, Arnaud Chignon, Samuel Mathieu
Publikováno v:
Human genomics. 16(1)
Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative
Autor:
Jean-Baptiste Manneville, Irene Brian, Silvia Pedretti, Patrizia Romani, Arianna Pocaterra, Mattia Forcato, Silvio Bicciato, Samuel Mathieu, Nico Mitro, Sirio Dupont, Matteo Audano, Giulia Santinon
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, In press, ⟨10.1038/s41556-018-0270-5⟩
Nature Cell Biology, Nature Publishing Group, In press, ⟨10.1038/s41556-018-0270-5⟩
International audience; Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general res
Autor:
Yohan Bossé, Patrick Mathieu, Samuel Mathieu, Benoit J. Arsenault, Christian Couture, Sébastien Thériault, Zhonglin Li
Publikováno v:
SSRN Electronic Journal.
We carried out a genome-wide association analysis including 51,194 cases of hypothyroidism and 443,383 controls. In total, 139 risk loci were associated to hypothyroidism with genes involved in lymphocyte function. Candidate genes associated with hyp