Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Samuel Maiwald"'
Autor:
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 527-530 (2022)
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide glu
Externí odkaz:
https://doaj.org/article/05018ca618a34ca08fb973d138964a14
Autor:
Christian Steinebach, Izidor Sosič, Aleša Bricelj, Arunima Murgai, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Annika Schmidt, Patricia Lemnitzer, Finn K. Hansen, Michael Gütschow, Jan Krönke, Marcus D. Hartmann
Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and lenalidomide represent the most typical cereblon (CRBN) recruiters that are frequently utilized in proteolysis-targeting chimera (PROTAC) design. These CRBN binders, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5007a3d3f5242a9a785fa538e7c06c1e
https://doi.org/10.26434/chemrxiv-2023-zshqp
https://doi.org/10.26434/chemrxiv-2023-zshqp
Autor:
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach
Publikováno v:
RSC chemical biology, 2023.
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa984d3da083d945a230ab521424c1f
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144171
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144171
Publikováno v:
ACS Medicinal Chemistry Letters
Repurposing E3 ubiquitin ligases for targeted protein degradation via customized molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality. Currently, a major limitation in the design of suitable mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab81ca1b0e39a56940c50a094368c2dd
http://europepmc.org/articles/PMC7812675
http://europepmc.org/articles/PMC7812675
Autor:
Mikhail Krasavin, Maria Adamchik, Andrey Bubyrev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Petr Zhmurov, Alexander Bunev, Marcus D. Hartmann
Publikováno v:
SSRN Electronic Journal.
To expand the chemical toolkit for targeted protein degradation, we report the generation of a new series of non-thalidomide Cereblon (CRBN) ligands. Readily available 2-methylidene glutarimide was converted to a series of 2-((hetero)aryl(methyl))thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f784a7dae349c1928cccb75c6368e4fd
https://doi.org/10.2139/ssrn.4191806
https://doi.org/10.2139/ssrn.4191806
Publikováno v:
ACS Medicinal Chemistry Letters. 13:148-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::461b43c7cadba27991f87f044414f782
https://doi.org/10.1021/acsmedchemlett.1c00693
https://doi.org/10.1021/acsmedchemlett.1c00693