Nonhuman primate genetic models for the study of rare diseases

Autor: Eric J. Vallender, Charlotte E. Hotchkiss, Anne D. Lewis, Jeffrey Rogers, Joshua A. Stern, Samuel M. Peterson, Betsy Ferguson, Ken Sayers

Publikováno v: Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-13 (2023)

Abstract Pre-clinical research and development relies heavily upon translationally valid models of disease. A major difficulty in understanding the biology of, and developing treatments for, rare disease is the lack of animal models. It is important

Externí odkaz: https://doaj.org/article/e2a4767fceee4ba6815e4c365ae0cc94

A novel non-human primate model of Pelizaeus-Merzbacher disease

Autor: Larry S. Sherman, Weiping Su, Amanda L. Johnson, Samuel M. Peterson, Cassandra Cullin, Tiffany Lavinder, Betsy Ferguson, Anne D. Lewis

Publikováno v: Neurobiology of Disease, Vol 158, Iss , Pp 105465- (2021)

Pelizaeus-Merzbacher disease (PMD) is a severe hypomyelinating disorder of the central nervous system (CNS) linked to mutations in the proteolipid protein-1 (PLP1) gene. Although there are multiple animal models of PMD, few of them fully mimic the hu

Externí odkaz: https://doaj.org/article/2d2d3e20c3af4b85b3ae0e3f5c95a2cb

Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis

Autor: Byung Park, Dennis Bourdette, Steven G. Kohama, Samuel M. Peterson, Betsy Ferguson, Ian J. Tagge, Michael K. Axthelm, Larry S. Sherman, Kristin S. Fitzpatrick, Aparna N. Govindan, Scott W. Wong, William D. Rooney, Minsha Manoharan, Grayson S. Wong

Publikováno v: Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 456-470 (2021)
Annals of Clinical and Translational Neurology

Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and periphery. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2a64809d2ce2a31bee447f2fd6f650
https://doaj.org/article/e3983dd963594c35b1d381ed7a651083

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Autor: E. Elizabeth Patton, Alessandro Brombin, Samuel M. Peterson, John H. Postlethwait, Hannah Brunsdon

Publikováno v: Brunsdon, H, Brombin, A, Peterson, S, Postlethwait, J H & Patton, E E 2022, ' Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells ', Development . https://doi.org/10.1242/dev.200277
Development

Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative processes are not well known. Here, using live imaging cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b278224dc94f14050dbbc0cab823f2e8
https://doi.org/10.1101/2021.09.23.461061

Embryonic ionizing radiation exposure results in expression alterations of genes associated with cardiovascular and neurological development, function, and disease and modified cardiovascular function in zebrafish

Autor: Jennifer L Freeman, Gregory J Weber, Samuel M Peterson, Linda H Nie

Publikováno v: Frontiers in Genetics, Vol 5 (2014)

The relationship between ionizing radiation (IR) and carcinogenesis is long established, but recently the association between IR and other diseases is starting to be recognized. Currently, there is limited information on the genetic mechanisms govern

Externí odkaz: https://doaj.org/article/f831649f1186425da625c9d37baa810a