Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Samuel M. Cadena"'
Autor:
Samuel M. Cadena, Yunyu Zhang, Jian Fang, Sophie Brachat, Pia Kuss, Elisa Giorgetti, Louis S. Stodieck, Michaela Kneissel, David J. Glass
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-b
Externí odkaz:
https://doaj.org/article/38bd92eb66384209bb03539a66816b7a
Autor:
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 749-763.e12 (2019)
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylas
Externí odkaz:
https://doaj.org/article/9e48897b13e34703b8199ceb48040546
Autor:
Ajeet Pratap Singh, Maria X. Sosa, Jian Fang, Shiva Kumar Shanmukhappa, Alexis Hubaud, Caroline H. Fawcett, Gregory J. Molind, Tingwei Tsai, Paola Capodieci, Kristie Wetzel, Ellen Sanchez, Guangliang Wang, Matthew Coble, Wenlong Tang, Samuel M. Cadena, Mark C. Fishman, David J. Glass
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2767-2776.e5 (2019)
Summary: The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan. Given the
Externí odkaz:
https://doaj.org/article/216e228e61be4f84a93547a2643bf2f0
Autor:
Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1522-1530 (2018)
Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass. GDF11 also elicited a significant elevation in plasma
Externí odkaz:
https://doaj.org/article/de796d96192e4bc598fb869ac2400859
Autor:
April E. Ronca, Eric L. Moyer, Yuli Talyansky, Moniece Lowe, Shreejit Padmanabhan, Sungshin Choi, Cynthia Gong, Samuel M. Cadena, Louis Stodieck, Ruth K. Globus
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/f1decefc0b7e4958a811610107671006
Autor:
Chia-Yu Wang, Emiliano Melgar-Bermudez, Diana Welch, Claire C Tseng, Ffolliott Fisher, Samuel M Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Publikováno v:
Blood. 140:5337-5338
Autor:
Johnny P Do, Samuel M. Cadena, Laura Schaevitz, Polina Stolyar, Mark D Rabe, Szczepan W Baran, Maria A Lim
Publikováno v:
The Journals of Gerontology: Series A. 76:1206-1213
To understand the growing needs of an aging human population, there is demand for scalable and reproducible approaches to study animal models of aging and to test novel therapeutic interventions. We investigated the sensitivity and utility of a conti
Autor:
Sungshin Y. Choi, Samuel M. Cadena, Yasaman Shirazi-Fard, Stephanie Solis, Louis S. Stodieck, Ruth K. Globus, Amanda M. Saravia-Butler, Dennis Leveson-Gower, April E. Ronca, J. Beegle
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Animal models are useful for exploring the health consequences of prolonged spaceflight. Capabilities were developed to perform experiments in low earth orbit with on-board sample recovery, thereby avoiding complications caused by return to Earth. Fo
Autor:
Pia Kuss, Michaela Kneissel, Louis S. Stodieck, Jian Fang, Sophie Brachat, Yunyu Zhang, David J. Glass, Elisa Giorgetti, Samuel M. Cadena
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based mode
Autor:
Chad Vickers, Sharon X. Wang, Estelle Lach-Trifilieff, Zhiping Chen, Xiaomei Wang, John R. Hadcock, Juli E. Jones, Hong Chen, Samuel M. Cadena, David J. Glass, Chenguang Gong
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1522-1530 (2018)
Cell Reports, Vol 22, Iss 12, Pp 3375-(2018)
Cell Reports, Vol 22, Iss 12, Pp 3375-(2018)
Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass. GDF11 also elicited a significant elevation in plasma