Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Samuel M Young"'
Autor:
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon I Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M Young Jr
Publikováno v:
eLife, Vol 11 (2022)
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release and replenish
Externí odkaz:
https://doaj.org/article/72cde114cf3040d9b27dec89dc94dd1c
Autor:
Laurie P Sutton, Cesare Orlandi, Chenghui Song, Won Chan Oh, Brian S Muntean, Keqiang Xie, Alice Filippini, Xiangyang Xie, Rachel Satterfield, Jazmine D W Yaeger, Kenneth J Renner, Samuel M Young Jr, Baoji Xu, Hyungbae Kwon, Kirill A Martemyanov
Publikováno v:
eLife, Vol 7 (2018)
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety. However, the molecular mechanisms underlying stress-responsive beh
Externí odkaz:
https://doaj.org/article/bc515a3f3b5740a393f3425dd4ab9426
Autor:
Matthias Lübbert, R Oliver Goral, Rachel Satterfield, Travis Putzke, Arn MJM van den Maagdenberg, Naomi Kamasawa, Samuel M Young Jr
Publikováno v:
eLife, Vol 6 (2017)
In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is principally mediated by CaV2.1 calcium channels (CaV2.1) and is highly dependent on the physical distance between CaV2.1 and synaptic vesicles (coupling). A
Externí odkaz:
https://doaj.org/article/58c989c989ce4ecf8e238d592ea303b8
Autor:
Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M. Young, Jr.
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101243- (2024)
Viral vector gene therapy has immense promise for treating central nervous system (CNS) disorders. Although adeno-associated virus vectors (AAVs) have had success, their small packaging capacity limits their utility to treat the root cause of many CN
Externí odkaz:
https://doaj.org/article/7b02bb63e17848869ba45957467fa715
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2082-2089 (2017)
Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output syna
Externí odkaz:
https://doaj.org/article/fa6f4f3e5d0f47ab84ac6a161d750d94
Autor:
Matthew V. Green, Thomas Pengo, Jonathan D. Raybuck, Tahmina Naqvi, Hannah M. McMullan, Jon E. Hawkinson, Ezequiel Marron Fernandez de Velasco, Brian S. Muntean, Kirill A. Martemyanov, Rachel Satterfield, Samuel M. Young, Stanley A. Thayer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are associated with environmental and drug-induced CNS toxicities. However, screening assays designed to
Externí odkaz:
https://doaj.org/article/696e303d6aaf4c8384cab892bc02e5d6
Publikováno v:
bioRxiv
Presynaptic voltage-gated Ca2+channels (CaV) subtype abundance at mammalian synapses regulates synaptic transmission in health and disease. In the mammalian central nervous system, most presynaptic terminals are CaV2.1 dominant with a developmental r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2da2d3682ad9eaba909284e289e6ac
https://doi.org/10.1101/2023.04.28.538778
https://doi.org/10.1101/2023.04.28.538778
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 117-126 (2022)
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 117-126 (2022)
Recombinant viral vectors have become integral tools for basic in vivo research applications. Helper-dependent adenoviral (HdAd) vectors have a large packaging capacity of ∼36 kb of DNA that mediate long-term transgene expression in vitro and in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79ffee55ce1457c20abcdefe724907f
http://europepmc.org/articles/PMC8718833
http://europepmc.org/articles/PMC8718833
Autor:
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon I Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c7af59d6ada0dc591cc8ce1b47dce9f
https://doi.org/10.7554/elife.81505.sa2
https://doi.org/10.7554/elife.81505.sa2
Autor:
Osama Tarabichi, Tatiana Correa, Emre Kul, Stacia Phillips, Bahaa Darkazanly, Samuel M. Young, Marlan R. Hansen
Publikováno v:
Hearing Research. :108819
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::501639f34b633ab9fb1df4983c3b34b0
https://doi.org/10.1016/j.heares.2023.108819
https://doi.org/10.1016/j.heares.2023.108819