Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Samuel M Young"'
Autor:
Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M. Young, Jr.
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101243- (2024)
Viral vector gene therapy has immense promise for treating central nervous system (CNS) disorders. Although adeno-associated virus vectors (AAVs) have had success, their small packaging capacity limits their utility to treat the root cause of many CN
Externí odkaz:
https://doaj.org/article/7b02bb63e17848869ba45957467fa715
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 117-126 (2022)
Recombinant viral vectors have become integral tools for basic in vivo research applications. Helper-dependent adenoviral (HdAd) vectors have a large packaging capacity of ∼36 kb of DNA that mediate long-term transgene expression in vitro and in vi
Externí odkaz:
https://doaj.org/article/aee6c45630ef4d808c234bb978453ef3
Autor:
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon I Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M Young Jr
Publikováno v:
eLife, Vol 11 (2022)
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release and replenish
Externí odkaz:
https://doaj.org/article/72cde114cf3040d9b27dec89dc94dd1c
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2082-2089 (2017)
Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output syna
Externí odkaz:
https://doaj.org/article/fa6f4f3e5d0f47ab84ac6a161d750d94
Autor:
Matthew V. Green, Thomas Pengo, Jonathan D. Raybuck, Tahmina Naqvi, Hannah M. McMullan, Jon E. Hawkinson, Ezequiel Marron Fernandez de Velasco, Brian S. Muntean, Kirill A. Martemyanov, Rachel Satterfield, Samuel M. Young, Stanley A. Thayer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are associated with environmental and drug-induced CNS toxicities. However, screening assays designed to
Externí odkaz:
https://doaj.org/article/696e303d6aaf4c8384cab892bc02e5d6
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 723-736 (2017)
GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we exami
Externí odkaz:
https://doaj.org/article/cb80837f50354dcd8a0d3458028144c5
Publikováno v:
bioRxiv
Presynaptic voltage-gated Ca2+channels (CaV) subtype abundance at mammalian synapses regulates synaptic transmission in health and disease. In the mammalian central nervous system, most presynaptic terminals are CaV2.1 dominant with a developmental r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2da2d3682ad9eaba909284e289e6ac
https://doi.org/10.1101/2023.04.28.538778
https://doi.org/10.1101/2023.04.28.538778
Autor:
Wei Dong, Tamara Radulovic, R. Oliver Goral, Connon Thomas, Monica Suarez Montesinos, Debbie Guerrero-Given, Akari Hagiwara, Travis Putzke, Yamato Hida, Manabu Abe, Kenji Sakimura, Naomi Kamasawa, Toshihisa Ohtsuka, Samuel M. Young, Jr.
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 284-293.e6 (2018)
Summary: In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels
Externí odkaz:
https://doaj.org/article/d0af342b3d8e4174a4c8048e4caa6636
Autor:
Laurie P Sutton, Cesare Orlandi, Chenghui Song, Won Chan Oh, Brian S Muntean, Keqiang Xie, Alice Filippini, Xiangyang Xie, Rachel Satterfield, Jazmine D W Yaeger, Kenneth J Renner, Samuel M Young Jr, Baoji Xu, Hyungbae Kwon, Kirill A Martemyanov
Publikováno v:
eLife, Vol 7 (2018)
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety. However, the molecular mechanisms underlying stress-responsive beh
Externí odkaz:
https://doaj.org/article/bc515a3f3b5740a393f3425dd4ab9426
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 117-126 (2022)
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 117-126 (2022)
Recombinant viral vectors have become integral tools for basic in vivo research applications. Helper-dependent adenoviral (HdAd) vectors have a large packaging capacity of ∼36 kb of DNA that mediate long-term transgene expression in vitro and in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79ffee55ce1457c20abcdefe724907f
http://europepmc.org/articles/PMC8718833
http://europepmc.org/articles/PMC8718833