Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samuel M Lee"'
Autor:
Samuel M. Lee, Carolina M. Pusec, Gregory H. Norris, Adam De Jesus, Alberto Diaz-Ruiz, Jose Muratalla, Andre Sarmento-Cabral, Grace Guzman, Brian T. Layden, Jose Cordoba-Chacon
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)
Background & Aims: Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce ste
Externí odkaz:
https://doaj.org/article/f5c89553ae6f4961a45e0c8514ac9991
Publikováno v:
Journal of Endocrinology. 257
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to a family of nuclear receptors that could serve as lipid sensors. PPARγ is the target of a group of insulin sensitizers called thiazolidinediones (TZDs) which regulate the expression o
Autor:
Samuel M. Lee, Jose Muratalla, Saman Karimi, Alberto Diaz-Ruiz, Maria Dolores Frutos, Grace Guzman, Bruno Ramos-Molina, Jose Cordoba-Chacon
Publikováno v:
Cellular and Molecular Life Sciences. 80
Background & AimsNon-alcoholic steatohepatitis (NASH) is associated with obesity and increased expression of hepatic peroxisome proliferator-activated receptor γ (PPARγ) in humans. Although we previously showed that the expression of PPARγ in hepa
Autor:
Brian T. Layden, Samuel M Lee, Carolina M. Pusec, Andre Sarmento-Cabral, Grace Guzman, Jose Muratalla, Jose Cordoba-Chacon, Alberto Diaz-Ruiz, Gregory H Norris, Adam De Jesus
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)
Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce stea
Autor:
Chong Wee Liew, Jose Cordoba-Chacon, Jose Muratalla, Maximillian McCann, Pablo Remon-Ruiz, Samuel M Lee, Alberto Diaz-Ruiz, Rhonda D. Kineman
Publikováno v:
Endocrinology
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Thiazolidinediones (TZD) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that may reduce hepatic steatosis through their effects in adipose tissue and therefore have been assessed as potential therapies to treat nonalcoholic fatty
Publikováno v:
Journal of the Endocrine Society
Pparg is a nuclear receptor that regulates glucose and lipid metabolism. Thiazolidinediones (TZD) are PPARG agonists that may reduce hepatic steatosis through their effects in adipose tissue. However, some studies suggest that expression and activati
Autor:
Samuel M, Lee, Seneshaw, Asress, Chadwick M, Hales, Marla, Gearing, Juan C, Vizcarra, Christina N, Fournier, David A, Gutman, Lih-Shen, Chin, Lian, Li, Jonathan D, Glass
Publikováno v:
Brain Communications
The G4C2 hexanucleotide repeat expansion mutation in the C9orf72 gene is the most common genetic cause underlying both amyotrophic lateral sclerosis and frontotemporal dementia. Pathologically, these two neurodegenerative disorders are linked by the
Autor:
Chadwick M. Hales, Marla Gearing, Lian Li, David A. Gutman, Samuel M. Lee, Lih-Shen Chin, Christina Fournier, Juan C. Vizcarra, Jonathan D. Glass, Seneshaw Asress
Publikováno v:
Brain Communications. 1
The G4C2 hexanucleotide repeat expansion mutation in the C9orf72 gene is the most common genetic cause underlying both amyotrophic lateral sclerosis and frontotemporal dementia. Pathologically, these two neurodegenerative disorders are linked by the
Publikováno v:
Molecular Neurobiology. 54:87-100
Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy with the majority of cases involving demyelination of peripheral nerves. The pathogenic mechanisms of demyelinating CMT remain unclear, and no effective therapy curr
Autor:
Jonathan D. Glass, Di Sha, Seneshaw Asress, Samuel M. Lee, Lian Li, Anum A. Mohammed, Lih-Shen Chin
Publikováno v:
Human Molecular Genetics. 22:1755-1770
Charcot-Marie-Tooth disease type 1C (CMT1C) is a dominantly inherited motor and sensory neuropathy. Despite human genetic evidence linking missense mutations in SIMPLE to CMT1C, the in vivo role of CMT1C-linked SIMPLE mutations remains undetermined.