Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Samuel Lotz"'
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
The formation of ternary degrader-protein complexes is a key step in the targeted degradation of proteins of interest. Here, the authors explore the structure and dynamics of such complexes applying high-performance computer simulations augmented wit
Externí odkaz:
https://doaj.org/article/c2e5bdee6705479cb8aa835a2985b507
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab Shrestha, Rafal Wiewiora, Zachary McDargh, Fen Pei, Rajat Pal, Joao Vieira Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus Izaguirre
Targeted protein degradation (TPD) has emerged as a powerful approach for removing (rather than inhibiting) proteins implicated in diseases. A key step in TPD is the formation of an induced proximity complex where a degrader molecule recruits an E3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e7b51e04cb88578da974b61782146b
https://doi.org/10.21203/rs.3.rs-1318882/v1
https://doi.org/10.21203/rs.3.rs-1318882/v1
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Targeted protein degradation (TPD) has emerged as a powerful approach in drug discovery for removing (rather than inhibiting) proteins implicated in diseases. A key step in this approach is the formation of an induced proximity complex, where a degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab72e51a2dd74a1d61536d796a4ff20
https://doi.org/10.1101/2021.09.26.461830
https://doi.org/10.1101/2021.09.26.461830
Autor:
Alex Dickson, Samuel Lotz
This paper describes the software tool "wepy", an implementation of the weighted ensemble algorithm in python. Wepy was designed to be a flexible simulation framework for rare or long-timescale molecular events, such as protein (un)folding, ligand (u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2586ef8b8652de7c488ff0511861dd74
https://doi.org/10.26434/chemrxiv.12801125
https://doi.org/10.26434/chemrxiv.12801125