Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site

Autor: Brice Le François, Jeremy Soo, Anne M. Millar, Mireille Daigle, Anne-Marie Le Guisquet, Samuel Leman, Frédéric Minier, Catherine Belzung, Paul R. Albert

Publikováno v: Neurobiology of Disease, Vol 82, Iss , Pp 332-341 (2015)

The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (MDD) where it is often found to be dys-regulated. However, the extent to which stress and antidepressant treatment im

Externí odkaz: https://doaj.org/article/4ef41eeaf68e4bb7a2ca3f5391366701

Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse

Autor: Vincent Camus, Anne Marie Le Guisquet, Katleen Pinchaud, Samuel Leman, Catherine Belzung, Romain Troubat, Alexandre Surget, Bruno Brizard, Sébastien Roger, Pascal Barone

Publikováno v: Brain, Behavior, and Immunity. 94:159-174

Background Several lines of evidence suggest that neuroinflammation might be a key neurobiological mechanism of depression. In particular, the P2X7 receptor (P2X7R), an ATP-gated ion channel involved in activation of the pro-inflammatory interleukin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aeb09c583905caf6503d0fb8bb8a3c
https://doi.org/10.1016/j.bbi.2021.02.012

EMC Results Analysis Using Statistical Comparison Criteria

Autor: Samuel Leman, Philippe Besnier, Sebastien Serpaud

Publikováno v: IEEE International Joint Symposium on Electromagnetic Compatibility (EMC), Signal and Power Integrity (SIPI) and EMC Europe
IEEE International Joint Symposium on Electromagnetic Compatibility (EMC), Signal and Power Integrity (SIPI) and EMC Europe, Jul 2021, Raleigh, United States. ⟨10.1109/EMC/SI/PI/EMCEurope52599.2021.9559369⟩

International audience; This paper presents an evaluation of statistical comparison criteria applied to analyze and to interpret EMC data results with their uncertainties characterizing an electronic system. Based on EMC simulated and/or measured res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e73b365f3b1f8af3dc03ef7b6899b75
https://hal.science/hal-03827255

Efficacy of chronic ultrasound neurostimulation on behaviors and distributed brain metabolism in depressive-like mice

Autor: Laurent Galineau, Samuel Leman, Catherine Belzung, Jean-Michel Escoffre, Wissam El-Hage, Bruno Brizard, Barbara Planchez, Antoine Lefèvre, Ayache Bouakaz, Patrick Emond, Marc Legrand, Clovis Tauber, Philippe Gosset, Anthony Novell

Major depression is one of the main factors contributing to the Global Burden of Disease. Current treatment strategies (e.g., antidepressants and neurostimulation techniques) of major depression show some limitations including inaccuracy and invasive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8279cee6d94aa816d7d602783254657

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

Autor: Sylviane Marouillat, Samuel Leman, Lydie Nadal-Desbarats, Christian R. Andres, Jean-Claude Lecron, Mustafa Si-Tahar, Amandine Descat, Blandine Madji Hounoum, Thomas Baranek, Patrick Vourc'h, Hervé Watier, Clément Bruno, Philippe Corcia, Jean-François Goossens, Anne-Frédérique Dessein, Hélène Blasco, Franck Patin

Publikováno v: Neurotherapeutics. 13:905-917

In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic impairment and neuroinflammation. Playing an important role in the regulation of both phenomena, interleukin (IL)-6, a major cytokine of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ed9b5b04719155eb4822b7ec61a4ee
https://doi.org/10.1007/s13311-016-0461-3