Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Samuel L. Wolock"'
Autor:
Danilo Pellin, Mariana Loperfido, Cristina Baricordi, Samuel L. Wolock, Annita Montepeloso, Olga K. Weinberg, Alessandra Biffi, Allon M. Klein, Luca Biasco
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Human Hematopoietic stem and progenitor cells (HSPCs) are commonly defined by CD34 expression. Here, the authors map single-cell RNA states both inside and outside the CD34 compartment, uncovering previously unappreciated branchpoints and validating
Externí odkaz:
https://doaj.org/article/b4d60ac10b844ab591805a070600b761
Autor:
Samuel L. Wolock, Indira Krishnan, Danielle E. Tenen, Victoria Matkins, Virginia Camacho, Sweta Patel, Puneet Agarwal, Ravi Bhatia, Daniel G. Tenen, Allon M. Klein, Robert S. Welner
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 302-311.e5 (2019)
Summary: The bone marrow microenvironment is composed of heterogeneous cell populations of non-hematopoietic cells with complex phenotypes and undefined trajectories of maturation. Among them, mesenchymal cells maintain the production of stromal, bon
Externí odkaz:
https://doaj.org/article/b3297ada2b054007be3ba2eea0670df5
Publikováno v:
Cancer Informatics, Vol 13s3 (2014)
As datasets increase in complexity, the time required for analysis (both computational and human domain-expert) increases. One of the significant impediments introduced by such burgeoning data is the difficulty in knowing what features to include or
Externí odkaz:
https://doaj.org/article/a0a70970d8034289b7de4d28a979699e
Autor:
Sweta B. Patel, Jake Y. Chen, Zongliang Yue, Victor M. Darley-Usmar, Brittany L. Crown, Ravi Bhatia, Daniel G. Tenen, Rui Lu, Li Ying, Paul Brent Ferrell, Davide Stefanoni, Ashley T. Hoang, Samuel L. Wolock, Danielle Tenen, Travis Nemkov, Angelo D'Alessandro, Robert S. Welner, Jihye Park, Henry Yang, Valeriya Kuznetsova, Gloria A. Benavides, Mahmoud A. Bassal, Virginia Camacho, Victoria R. Matkins
Publikováno v:
Leukemia
Leukemic stem cells (LSCs) can acquire non-mutational resistance following drug treatment leading to therapeutic failure and relapse. However, oncogene-independent mechanisms of drug persistence in LSCs are incompletely understood, which is the prima
Autor:
Olga K. Weinberg, Cristina Baricordi, Mariana Loperfido, Danilo Pellin, Luca Biasco, Allon M. Klein, Annita Montepeloso, Samuel L. Wolock, Alessandra Biffi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts, the nature of the early cell fate decisions remains contentious. Using single-cell R
Autor:
Jun R. Huh, Yung Hwang, Merav Socolovsky, Allon M. Klein, Ari Waisman, Rapolas Zilionis, Caleb Weinreb, Samuel L. Wolock, Betsabeh Khoramian Tusi, Daniel Hidalgo
Publikováno v:
Nature
The formation of red blood cells begins with the differentiation of multipotent haematopoietic progenitors. Reconstructing the steps of this differentiation represents a general challenge in stem-cell biology. Here we used single-cell transcriptomics
Autor:
Jianlong Sun, Maja Jankovic, Fernando D. Camargo, Samuel L. Wolock, Allon M. Klein, Sachin Patel, Riccardo Panero, Raffaele A. Calogero, Caleb Weinreb, Alejo E. Rodriguez-Fraticelli
Publikováno v:
Nature
Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been propose
Autor:
Sweta B. Patel, Samuel L. Wolock, Ravi Bhatia, Allon M. Klein, Indira Krishnan, Daniel G. Tenen, Virginia Camacho, Robert S. Welner, Victoria R. Matkins, Danielle Tenen, Puneet Agarwal
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 302-311.e5 (2019)
Summary: The bone marrow microenvironment is composed of heterogeneous cell populations of non-hematopoietic cells with complex phenotypes and undefined trajectories of maturation. Among them, mesenchymal cells maintain the production of stromal, bon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Seeing a snapshot of individuals at different stages of a dynamic process can reveal what the process would look like for a single individual over time. Biologists apply this principle to infer temporal sequences of gene expression state
Autor:
Allon M. Klein, Jun R. Huh, Daniel Hidalgo, Samuel L. Wolock, Yung Hwang, Rapolas Zilionis, Ari Waisman, Caleb Weinreb, Betsabeh Khoramian Tusi, Merav Socolovsky
Red cell formation begins with the hematopoietic stem cell, but the manner by which it gives rise to erythroid progenitors, and their subsequent developmental path, remain unclear. Here we combined single-cell transcriptomics of murine hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2504a96e10e00ae10c467c25fc3654de
https://doi.org/10.1101/261941
https://doi.org/10.1101/261941