Výsledky vyhledávání - "Samuel L. Svendsen"

Unrecognized role of claudin-10b in basolateral membrane infoldings of the thick ascending limb

Autor: Catarina Quintanova, Nina Himmerkus, Samuel L. Svendsen, Otto von Schwerdtner, Cosima Merkel, Lennart Pinckert, Kerim Mutig, Tilman Breiderhoff, Dominik Müller, Dorothee Günzel, Markus Bleich

Publikováno v: Quintanova, C, Himmerkus, N, Svendsen, S L, von Schwerdtner, O, Merkel, C, Pinckert, L, Mutig, K, Breiderhoff, T, Müller, D, Günzel, D & Bleich, M 2022, ' Unrecognized role of claudin-10b in basolateral membrane infoldings of the thick ascending limb ', Annals of the New York Academy of Sciences, vol. 1517, no. 1, pp. 266-278 . https://doi.org/10.1111/nyas.14882

Claudin-10b is an important component of the tight junction in the thick ascending limb (TAL) of Henle's loop and allows paracellular sodium transport. In immunofluorescence stainings, claudin-10b–positive cells exhibited extensive extra staining o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0fb53be8102217a82dd96cb5702ed4
https://pure.au.dk/ws/files/330383335/Annals_of_the_New_York_Academy_of_Sciences_2022_Quintanova_Unrecognized_role_of_claudin_10b_in_basolateral_membrane.pdf

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Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases

Autor: Jesper Frank Andersen, Charles S. Wingo, Jens Leipziger, Niklas Ayasse, I. Jeanette Lynch, Natalya U. Fedosova, Samuel L Svendsen, Mads V. Sorensen, Peder Berg

Publikováno v: Ayasse, N, Berg, P, Andersen, J F, Svendsen, S L S C, Sørensen, M V, Fedosova, N, Wingo, C, Lynch, I J & Leipziger, J G 2021, ' Benzamil-mediated urine alkalization is caused by the inhibition of H +, K + ATPases ', American Journal of Physiology: Renal Physiology, vol. 320, no. 4, pp. F596-F607 . https://doi.org/10.1152/ajprenal.00444.2020

Epithelial Na+ channel (ENaC) blockers elicit acute and substantial increases of urinary pH. The underlying mechanism remains to be understood. Here, we evaluated if benzamil-induced urine alkalization is mediated by an acute reduction in H+ secretio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb42c5990e38c42a7751b24b66b2eba
https://doi.org/10.1152/ajprenal.00444.2020

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NBCn1 Increases NH4 + Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH4 + Excretion, and Early Recovery from Metabolic Acidosis

Autor: Jeppe Olsen, Vladimir V. Matchkov, Mads V. Sorensen, Ebbe Boedtkjer, Peder Berg, Vibeke Secher Dam, Samuel L Svendsen, Jens Leipziger

Publikováno v: Olsen, J S, Svendsen, S L S C, Berg, P, Dam, V S, Sørensen, M V, Matchkov, V, Leipziger, J G & Boedtkjer, E 2021, ' NBCn1 increases NH 4 + reabsorption across thick ascending limbs, the capacity for urinary NH 4 + excretion, and early recovery from metabolic acidosis ', Journal of the American Society of Nephrology, vol. 32, no. 4, pp. 852-865 . https://doi.org/10.1681/ASN.2019060613

BACKGROUND: The electroneutral Na +/HCO 3 - cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a835ca1be44c60d3cec5ac3b7546b56c
https://doi.org/10.1681/asn.2019060613

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Dietary K + acts as a genuine diuretic

Autor: Samuel L. Svendsen, Simon Kornvig, Peder Berg, Iben S. Jensen, Isabela B. B. A. de Araujo, Casper K. Larsen, Jens Leipziger, Mads V. Sørensen

Publikováno v: Svendsen, S L S C, Kornvig, S, Berg, P, Jensen, I S, Bastos Binotti Abreu De Araujo, I, Larsen, C K, Leipziger, J G & Sørensen, M V 2022, ' Dietary K + acts as a genuine diuretic ', Acta Physiologica (Online) . https://doi.org/10.1111/apha.13762
Svendsen, S L, Kornvig, S, Berg, P, Jensen, I S, de Araujo, I B B A, Larsen, C K, Leipziger, J & Sorensen, M V 2022, ' Dietary K + acts as a genuine diuretic ', Acta Physiologica, vol. 234, no. 2, e13762 . https://doi.org/10.1111/apha.13762

K+ balance in mammals relies on regulated renal K+ excretion matching unregulated fluctuating K+ intake. Upon a K+ rich meal, rapid and powerful K+ excretion is needed. Renal K+ secretion is stimulated by increased tubular flow. We speculated that hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d5ac85159b7324c33842d294ad8b83
https://pure.au.dk/portal/da/publications/dietary-k--acts-as-a-genuine-diuretic(041f0e85-4519-44ea-9794-a076b6f89fc5).html

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Dietary K

Autor: Samuel L, Svendsen, Simon, Kornvig, Peder, Berg, Iben S, Jensen, Isabela B B A, de Araujo, Casper K, Larsen, Jens, Leipziger, Mads V, Sørensen

Publikováno v: Acta physiologica (Oxford, England)REFERENCES. 234(2)

KMice were K(1) Mice switched from a 1% to 2% KDietary K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a188f3434ef12d794058e0371b7d8d47
https://pubmed.ncbi.nlm.nih.gov/34984847

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The molecular mechanism of CFTR- and secretin-dependent renal bicarbonate excretion

Autor: Samuel L Svendsen, Rainer Schreiber, Mads V. Sorensen, Jens Leipziger, Karl Kunzelmann, Peder Berg

Publikováno v: Berg, P, Svendsen, S L, Sorensen, M V, Schreiber, R, Kunzelmann, K & Leipziger, J 2021, ' The molecular mechanism of CFTR-and secretin-dependent renal bicarbonate excretion ', The Journal of Physiology, vol. 599, no. 12, pp. 3003-3011 . https://doi.org/10.1113/JP281285

This review summarizes the newly discovered molecular mechanism of secretin-stimulated urine HCO3- excretion and the role of CFTR in renal HCO3- excretion. The secretin receptor is functionally expressed in the basolateral membrane of the HCO3- secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b876be2e3cdf7216bb70fc03912deedb
https://pubmed.ncbi.nlm.nih.gov/33963548

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Impaired renal HCO 3 − secretion in CFTR deficient mice causes metabolic alkalosis during chronic base‐loading

Autor: Helle A. Praetorius, Samuel L Svendsen, Mads V. Sorensen, Thi Thuy Linh Hoang, Peder Berg, Jens Leipziger

Publikováno v: Berg, P, Svendsen, S L, Hoang, T T L, Praetorius, H A, Sørensen, M V & Leipziger, J 2021, ' Impaired renal HCO 3-secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading ', Acta Physiologica, vol. 231, no. 3, e13591 . https://doi.org/10.1111/apha.13591

Aim: Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCO3- handling. In this study, we directly assess the kidneys’ ability to compensate for a chronic base-load in the absen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b4f2907f89f3036aa3ac3ef89dc4f9
https://doi.org/10.1111/apha.13591

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Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics

Autor: Paul A. Welling, Samuel L Svendsen, Catarina Quintanova, Nina Himmerkus, Markus Bleich, Otto Von Schwerdtner, Thomas Benzing, Markus M. Rinschen, Jens Leipziger

Publikováno v: Himmerkus, N, Svendsen, S L, Quintanova, C, Bleich, M, Von Schwerdtner, O, Benzing, T, Welling, P A, Leipziger, J & Rinschen, M M 2020, ' Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics ', Function, vol. 1, no. 1, pp. zqaa007 . https://doi.org/10.1093/function/zqaa007

The revolution of the omics technologies has enabled profiling of the molecules of any sample. However, the heterogeneity of the kidney with highly specialized nephron segments like the cortical collecting duct (CCD) poses a challenge regarding integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c075514c713f9dd303e3e0245536652
https://pubmed.ncbi.nlm.nih.gov/35330744

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Impaired renal HCO

Autor: Peder, Berg, Samuel L, Svendsen, Thi Thuy Linh, Hoang, Helle A, Praetorius, Mads V, Sorensen, Jens, Leipziger

Publikováno v: Acta physiologica (Oxford, England)REFERENCES. 231(3)

Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCOComprehensive urine and blood acid-base analyses were done in anaesthetized WT mice or mice lacking either CFTR or pendrin, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0ca2e359093a8a87dffa6c2ed5b3d08
https://pubmed.ncbi.nlm.nih.gov/33270356

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Impaired Renal HCO

Autor: Rainer Schreiber, Jens Leipziger, Majbritt Jeppesen, Jesper Frank Andersen, Karl Kunzelmann, Inês Cabrita, Samuel L Svendsen, Mads V. Sorensen, Søren Jensen-Fangel, Peder Berg, Casper Larsen

Publikováno v: J Am Soc Nephrol
Berg, P, Svendsen, S L S C, Sørensen, M V, Larsen, C K, Andersen, J F, Jensen-Fangel, S, Jeppesen, M, Schreiber, R, Cabrita, I, Kunzelmann, K & Leipziger, J G 2020, ' Impaired Renal HCO3-Excretion in Cystic Fibrosis ', Journal of the American Society of Nephrology, vol. 31, no. 8, 31, pp. 1711-1727 . https://doi.org/10.1681/ASN.2020010053

BACKGROUND: Patients with cystic fibrosis (CF) do not respond with increased urinary HCO(3)(−) excretion after stimulation with secretin and often present with metabolic alkalosis. METHODS: By combining RT-PCR, immunohistochemistry, isolated tubule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cea15b2f7e4fdbf477a3a4ae9aa197
https://pubmed.ncbi.nlm.nih.gov/32716314

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