Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Samuel L, Scinto"'
Publikováno v:
Angewandte Chemie International Edition. 61
The site-selective functionalization of proteins has broad application in chemical biology, but can be limited when mixtures result from incomplete conversion or the formation of protein containing side products. It is shown here that when proteins a
Autor:
Oshini Ekanayake, Christopher W. am Ende, Samuel L. Scinto, Uthpala Seneviratne, Samantha J. Boyd, Michael T. Taylor, Sharon Rozovsky, Jessica E. Pigga, Jun Liu, Joseph M. Fox
Publikováno v:
Journal of the American Chemical Society. 141:10932-10937
Sulfenylation (RSH → RSOH) is a post-translational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to t
Autor:
A.C. Moore, Samuel L. Scinto, Kevin T. Dicker, Joseph M. Fox, David L. Burris, Han Zhang, Robert E. Akins, Xinqiao Jia, Nikolay T. Garabedian
Publikováno v:
ACS Appl Mater Interfaces
Fully integrated hydrogel channels were fabricated via interfacial bioorthogonal cross-linking, a diffusion-controlled method for the creation and patterning of synthetic matrices based on the rapid bioorthogonal reaction between s-tetrazines (Tz) an
Autor:
Samuel L. Scinto, Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu, Christopher W. am Ende, M. G. Finn, Kathrin Lang, Qing Lin, John Paul Pezacki, Jennifer A. Prescher, Marc S. Robillard, Joseph M. Fox
Publikováno v:
Nature reviews. Methods primers, vol 1, iss 1
Nat Rev Methods Primers
Nat Rev Methods Primers
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups. Rooted in the principles of physical organic c
Autor:
Xinqiao Jia, Samuel L. Scinto, David L. Burris, He Zhang, Aidan B. Zerdoum, A.C. Moore, Shuang Liu, Han Zhang, Ayyappan K. Rajasekaran, Liang Gong, Joseph M. Fox
Publikováno v:
Biomaterials. 180:24-35
Fibrous proteins found in the natural extracellular matrix (ECM) function as host substrates for migration and growth of endogenous cells during wound healing and tissue repair processes. Although various fibrous scaffolds have been developed to reca
Autor:
Matthew R Jensen, Junhui Zhou, Hai Liang, Elizabeth A. D'Ambrosio, Kristen E. DeMeester, Zachary S Jones, Catherine L. Grimes, Samuel L. Scinto
Publikováno v:
Journal of the American Chemical Society. 140:9458-9465
Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial peptidoglycan (PG) biosynthesis. As the primary source of muramic acid that shapes the PG backbone, modifications installed at the UDP NAM intermediate can be
Autor:
Zhen Huang, Douglas S. Johnson, Olga Dmitrenko, Joseph M. Fox, Samuel L. Scinto, Han Zhang, Christopher W. am Ende, Jeffrey Yang, Yinzhi Fang
Publikováno v:
Chemical Science. 9:1953-1963
A photochemical synthesis of AgNO3 complexes of trans-cycloheptene (TCH) and trans-1-sila-4-cycloheptene (Si-TCH) derivatives is described. A low temperature flow photoreactor was designed to enable the synthesis of carbocyclic TCH derivatives due to
Autor:
Samuel L, Scinto, Oshini, Ekanayake, Uthpala, Seneviratne, Jessica E, Pigga, Samantha J, Boyd, Michael T, Taylor, Jun, Liu, Christopher W, Am Ende, Sharon, Rozovsky, Joseph M, Fox
Publikováno v:
J Am Chem Soc
Sulfenylation (RSH ->RSOH) is a posttranslational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to thei
Autor:
Samuel L. Scinto, Joseph M. Fox, Han Zhang, Nikifar Lazouski, Colin Thorpe, Shuang Liu, Xinqiao Jia, Gabriel A. Andrade, Joel Rosenthal, Yi Li, William S. Trout, Devin A. Hudson, Kevin T. Dicker
Publikováno v:
Journal of the American Chemical Society. 138:5978-5983
Rapid bioorthogonal reactivity can be induced by controllable, catalytic stimuli using air as the oxidant. Methylene blue (4 μM) irradiated with red light (660 nm) catalyzes the rapid oxidation of a dihydrotetrazine to a tetrazine thereby turning on
Autor:
Yinzhi, Fang, Han, Zhang, Zhen, Huang, Samuel L, Scinto, Jeffrey C, Yang, Christopher W, Am Ende, Olga, Dmitrenko, Douglas S, Johnson, Joseph M, Fox
Publikováno v:
Chemical Science
Synthesis and transformations of AgNO3 complexes of trans-cycloheptene (TCH) and trans-1-sila-4-cycloheptene (Si-TCH) derivatives are described.
A photochemical synthesis of AgNO3 complexes of trans-cycloheptene (TCH) and trans-1-sila-4-cyclohep
A photochemical synthesis of AgNO3 complexes of trans-cycloheptene (TCH) and trans-1-sila-4-cyclohep