Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Samuel Korman"'
Autor:
Mingyan Cao, G. Patrick Hussmann, Yeqing Tao, Ellen O’Connor, Conner Parthemore, Diana Zhang-Hulsey, Dengfeng Liu, Yang Jiao, Niluka de Mel, Meagan Prophet, Samuel Korman, Jaytee Sonawane, Christina Grigoriadou, Yue Huang, Scott Umlauf, Xiaoyu Chen
Publikováno v:
Antibodies, Vol 12, Iss 4, p 68 (2023)
Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic asparagine deamidation is observed frequently during the manufacturing, processing, and/or storage
Externí odkaz:
https://doaj.org/article/4a1c6cf978184bb1870f19d9d0c1a91e
Autor:
Mingyan Cao, Yang Jiao, Conner Parthemore, Samuel Korman, Jiao Ma, Alan Hunter, Greg Kilby, Xiaoyu Chen
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulf
Externí odkaz:
https://doaj.org/article/856756af5dca4848857256f0e2f60f64
Autor:
Greg Kilby, Xiaoyu Chen, Matthew Aspelund, Conner Parthemore, Alan K. Hunter, Yang Jiao, Mingyan Cao, Samuel Korman
Publikováno v:
Journal of pharmaceutical sciences. 110(8)
Site-specific cysteine engineering, along with other genetic mutations, is broadly implemented in bispecific antibodies (bsAb). Thus far, homodimer, half hole antibody, one-light chain mispaired and light chain swapped variants have been reported as
Autor:
Greg Kilby, Yang Jiao, Xiaoyu Chen, Mingyan Cao, Conner Parthemore, Alan K. Hunter, Jiao Ma, Samuel Korman
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulf
Autor:
Samuel Korman
Publikováno v:
Annals of the New York Academy of Sciences. 88:460-473
Autor:
Cao, Mingyan1 (AUTHOR) mingyan.x.cao@gsk.com, Hussmann, G. Patrick1 (AUTHOR) jiaoyang88552@gmail.com, Tao, Yeqing1 (AUTHOR) niluka.demel@astrazeneca.com, O'Connor, Ellen1 (AUTHOR) christina.grigoriadou@astrazeneca.com, Parthemore, Conner1 (AUTHOR), Zhang-Hulsey, Diana1 (AUTHOR), Liu, Dengfeng1 (AUTHOR), Jiao, Yang1 (AUTHOR), Mel, Niluka de1 (AUTHOR), Prophet, Meagan1 (AUTHOR), Korman, Samuel1 (AUTHOR), Sonawane, Jaytee1 (AUTHOR), Grigoriadou, Christina1 (AUTHOR), Huang, Yue2 (AUTHOR), Umlauf, Scott1 (AUTHOR), Chen, Xiaoyu1 (AUTHOR)
Publikováno v:
Antibodies (2073-4468). Dec2023, Vol. 12 Issue 4, p68. 22p.
Autor:
Samuel Korman, Moses D. Tendler
Publikováno v:
The Journal of New Drugs. 5:275-284
Autor:
Samuel Korman, Hans T. Clarke
Publikováno v:
Journal of Biological Chemistry. 221:133-141
Autor:
Victor K. La Mer, Samuel Korman
Publikováno v:
Journal of the American Chemical Society. 58:1396-1403
Publikováno v:
Journal of Clinical Investigation. 40:697-702
The turnover rates of I131 labeled beta and gamma globulins in a hypergammaglobulinemic multiple myeloma patient were compared by the conventional serum and urinary excretion methods with those found using the in vivo whole-body gamma spectrometer co