Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Samuel Kilcher"'
Autor:
Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial
Externí odkaz:
https://doaj.org/article/15efe631889b4075b2703227b046234f
Autor:
Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossmann, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Guebeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The rapid detection and species-level differentiation of bacterial pathogens facilitates antibiotic stewardship and improves disease management. Here, we develop a rapid bacteriophage-based diagnostic assay to detect the most prevalent patho
Externí odkaz:
https://doaj.org/article/380bf3f0f3d44554830c4469d686c355
Autor:
Eric T Sumrall, Yang Shen, Anja P Keller, Jeanine Rismondo, Maria Pavlou, Marcel R Eugster, Samy Boulos, Olivier Disson, Pierre Thouvenot, Samuel Kilcher, Bernd Wollscheid, Didier Cabanes, Marc Lecuit, Angelika Gründling, Martin J Loessner
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008032 (2019)
The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clini
Externí odkaz:
https://doaj.org/article/7cf281dab827499aa29aa89c454981e8
Autor:
Matthew Dunne, Beatrice Rupf, Marc Tala, Xhem Qabrati, Patrick Ernst, Yang Shen, Eric Sumrall, Laura Heeb, Andreas Plückthun, Martin J. Loessner, Samuel Kilcher
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1336-1350.e4 (2019)
Summary: Bacteriophages provide excellent tools for diagnostics, remediation, and targeted microbiome manipulation, yet isolating viruses with suitable host specificity remains challenging. Using Listeria phage PSA, we present a synthetic biology blu
Externí odkaz:
https://doaj.org/article/200cd6e5a7a6410884b91266bea120d4
Publikováno v:
Viruses, Vol 12, Iss 9, p 944 (2020)
Fast and reliable detection of bacterial pathogens in clinical samples, contaminated food products, and water supplies can drastically improve clinical outcomes and reduce the socio-economic impact of disease. As natural predators of bacteria, bacter
Externí odkaz:
https://doaj.org/article/5c7e9fdc9a30470abd2e54cd3071372a
Autor:
Jan C. Wohlfarth, Miki Feldmüller, Alissa Schneller, Samuel Kilcher, Marco Burkolter, Susanne Meile, Martin Pilhofer, Markus Schuppler, Martin J. Loessner
Publikováno v:
Nature Microbiology, 8 (3)
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-degrading endolysins that cause explosive cell lysis of the host can also attack non-infected bystander cells. Here we show that in osmotically stabilized
Autor:
Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossman, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Gübeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher
The rapid detection and species-level differentiation of bacterial pathogens facilitates antibiotic stewardship and improves disease management. Here, we develop a rapid bacteriophage-based diagnostic assay to detect the most prevalent pathogens caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3be2c4cfae4c1744b7a2b63e0d1bfee
https://doi.org/10.1101/2022.11.23.517494
https://doi.org/10.1101/2022.11.23.517494
Autor:
Jan C. Wohlfarth, Miki Feldmüller, Alissa Schneller, Samuel Kilcher, Marco Burkolter, Martin Pilhofer, Markus Schuppler, Martin J. Loessner
Bacteriophages kill bacteria by osmotic lysis towards the end of the lytic cycle. In the case of Gram-positive bacteria, peptidoglycan-degrading endolysins released at the end of infection cycle cause explosive cell lysis not only of the infected hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a7f9367d4ba69be2137155a577085e
https://doi.org/10.1101/2022.05.24.493201
https://doi.org/10.1101/2022.05.24.493201
Autor:
Lorenz Leitner, Jiemin Du, Susanne Meile, Shawna McCallin, Vera Neumeier, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne
Publikováno v:
Journal of Urology. 207
Autor:
Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne
Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternatives. However, phage-mediated killing is often limited by bacterial resistance development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac3b9aba522c95d74a448188a7a5e10
https://doi.org/10.1101/2022.03.09.483629
https://doi.org/10.1101/2022.03.09.483629