Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Samuel K McBrayer"'
Autor:
Joseph D Buehler, Cylaina E Bird, Milan R Savani, Lauren C Gattie, William H Hicks, Michael M Levitt, Mohamad El Shami, Kimmo J Hatanpaa, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
Cancer Informatics, Vol 21 (2022)
The creation of patient-derived cancer organoids represents a key advance in preclinical modeling and has recently been applied to a variety of human solid tumor types. However, conventional methods used to assess in vivo tumor tissue treatment respo
Externí odkaz:
https://doaj.org/article/12674b086d134b5cb1505f9925a80c9f
Autor:
William H. Hicks, Lauren C. Gattie, Mohamad El Shami, Jeffrey I. Traylor, Diwakar Davar, Yana G. Najjar, Timothy E. Richardson, Samuel K. McBrayer, Kalil G. Abdullah
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Despite advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part, by shortcomings in existing pre
Externí odkaz:
https://doaj.org/article/cc6ec6088af94eb597fdd2740217f6ae
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Gliomas are the most common primary brain tumor and are uniformly lethal. Despite significant advancements in understanding the genetic landscape of gliomas, standard-of-care has remained largely unchanged. Subsets of gliomas are defined by
Externí odkaz:
https://doaj.org/article/5ee1cd603db944a4982d6aba936716b7
Autor:
Samuel K McBrayer, Michael Yarrington, Jun Qian, Gang Feng, Mala Shanmugam, Varsha Gandhi, Nancy L Krett, Steven T Rosen
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41455 (2012)
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories due to the selective cytotoxicity they exhibit toward multiple myeloma (MM), chronic lympho
Externí odkaz:
https://doaj.org/article/ce2dd1a9fa4b4a2182000f7cef7092bb
Autor:
Diana D. Shi, Joyce H. Lee, Adam C. Wang, Januka Khanal, Wenhua Gao, William G. Kaelin, Jr., Samuel K. McBrayer
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102281- (2023)
Summary: Lower-grade gliomas exhibit a high prevalence of isocitrate dehydrogenase 1 (IDH1) mutations, but faithful models for studying these tumors are lacking. Here, we present a protocol to establish a genetically engineered mouse (GEM) model of g
Externí odkaz:
https://doaj.org/article/28d231ea93034d8da81fffb340a70d54
Autor:
Lilly W. Tang, Arka N. Mallela, Hansen Deng, Timothy E. Richardson, Shawn L. Hervey-Jumper, Samuel K. McBrayer, Kalil G. Abdullah
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Models for human gliomas prove critical not only to advancing our understanding of glioma biology but also to facilitate the development of therapeutic modalities. Specifically, creating lower-grade glioma (LGG) models has been challenging, contribut
Externí odkaz:
https://doaj.org/article/e11a1a02c2c24b458f0e77b541b02f81
Autor:
Kathryn Gunn, Matti Myllykoski, John Z. Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Samuel K. McBrayer, Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman
Publikováno v:
Cancer Discovery. :OF1-OF20
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17a831bbaa9e912c12db5173510ed71
https://doi.org/10.1158/2159-8290.cd-22-0825
https://doi.org/10.1158/2159-8290.cd-22-0825
Publikováno v:
Journal of Neuro-Oncology. 162:515-523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed51a5c1d48def81b82fac8efc30db7
https://doi.org/10.1007/s11060-022-04172-8
https://doi.org/10.1007/s11060-022-04172-8
Autor:
Mohamad El Shami, Milan R Savani, Lauren C Gattie, Bailey Smith, William H Hicks, Jeremy N Rich, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
bioRxiv
Purpose: Metabolism within the tumor microenvironment (TME) represents an increasing area of interest to understand glioma initiation and progression. Stable isotope tracing is a technique critical to the study of tumor metabolism. Cell culture model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec83769172783afc1a682f89e7f6885
https://europepmc.org/articles/PMC10312566/
https://europepmc.org/articles/PMC10312566/
Autor:
Nikhil Sharma, Arka N Mallela, Diana D Shi, Lilly W Tang, Hussam Abou-Al-Shaar, Zachary C Gersey, Xiaoran Zhang, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
Neuro-Oncology Advances.
Isocitrate dehydrogenase (IDH) is a key enzyme in normal metabolism and homeostasis. However, mutant forms of IDH are also defining features of a subset of diffuse gliomas. In this review, we highlight current techniques targeting IDH-mutated gliomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66208a928866d535714213f70c08f26
https://doi.org/10.1093/noajnl/vdad053
https://doi.org/10.1093/noajnl/vdad053