Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Samuel K McBrayer"'
Autor:
Joseph D Buehler, Cylaina E Bird, Milan R Savani, Lauren C Gattie, William H Hicks, Michael M Levitt, Mohamad El Shami, Kimmo J Hatanpaa, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
Cancer Informatics, Vol 21 (2022)
The creation of patient-derived cancer organoids represents a key advance in preclinical modeling and has recently been applied to a variety of human solid tumor types. However, conventional methods used to assess in vivo tumor tissue treatment respo
Externí odkaz:
https://doaj.org/article/12674b086d134b5cb1505f9925a80c9f
Autor:
Samuel K McBrayer, Michael Yarrington, Jun Qian, Gang Feng, Mala Shanmugam, Varsha Gandhi, Nancy L Krett, Steven T Rosen
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41455 (2012)
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories due to the selective cytotoxicity they exhibit toward multiple myeloma (MM), chronic lympho
Externí odkaz:
https://doaj.org/article/ce2dd1a9fa4b4a2182000f7cef7092bb
Autor:
Kathryn Gunn, Matti Myllykoski, John Z. Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Samuel K. McBrayer, Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman
Publikováno v:
Cancer Discovery. :OF1-OF20
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Publikováno v:
Journal of Neuro-Oncology. 162:515-523
Autor:
Mohamad El Shami, Milan R Savani, Lauren C Gattie, Bailey Smith, William H Hicks, Jeremy N Rich, Timothy E Richardson, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
bioRxiv
Purpose: Metabolism within the tumor microenvironment (TME) represents an increasing area of interest to understand glioma initiation and progression. Stable isotope tracing is a technique critical to the study of tumor metabolism. Cell culture model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec83769172783afc1a682f89e7f6885
https://europepmc.org/articles/PMC10312566/
https://europepmc.org/articles/PMC10312566/
Autor:
Nikhil Sharma, Arka N Mallela, Diana D Shi, Lilly W Tang, Hussam Abou-Al-Shaar, Zachary C Gersey, Xiaoran Zhang, Samuel K McBrayer, Kalil G Abdullah
Publikováno v:
Neuro-Oncology Advances.
Isocitrate dehydrogenase (IDH) is a key enzyme in normal metabolism and homeostasis. However, mutant forms of IDH are also defining features of a subset of diffuse gliomas. In this review, we highlight current techniques targeting IDH-mutated gliomas
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Inhibition of KDM5 enzymes by the (R)- and (S)-enantiomers of 2-hydroxyglutarate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bd98d6fef3b3201467d1983718c2c7
https://doi.org/10.1158/2159-8290.22726179
https://doi.org/10.1158/2159-8290.22726179
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Supplementary Table S9 shows the gene set enrichment analysis gene set that corresponds to Figure S6A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1c7a0c07433053d1104ba768d7d3b7
https://doi.org/10.1158/2159-8290.22726125
https://doi.org/10.1158/2159-8290.22726125
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
List of supplementary figures and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dd59e22e8ff31e5a9fd98c7e36cc5e
https://doi.org/10.1158/2159-8290.22726188.v1
https://doi.org/10.1158/2159-8290.22726188.v1
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b46c54a46a79fa7c618db044703ef3e
https://doi.org/10.1158/2159-8290.c.6624819.v1
https://doi.org/10.1158/2159-8290.c.6624819.v1