Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Samuel K Kulp"'
Autor:
Sophia G Liva, Yu‐Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi‐Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii‐Saab, Mitchell A Phelps, Ching‐Shih Chen, Christopher C Coss
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Abstract No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse and
Externí odkaz:
https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8
Autor:
Su-Lin Lee, Chih-Chien Chou, Hsiao-Ching Chuang, En-Chi Hsu, Po-Chen Chiu, Samuel K Kulp, John C Byrd, Ching-Shih Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67149 (2013)
Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line speci
Externí odkaz:
https://doaj.org/article/b2c8fdea46454f19ba16c77a553e7492
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47298 (2012)
Substantial evidence supports the oncogenic role of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2) in many types of cancers through its ability to target a broad range of signaling effectors for ubiquitination. Thus, this oncogeni
Externí odkaz:
https://doaj.org/article/fb261384b1ab4fb8bf57b413a1d80acc
Autor:
David M Lucas, Lapo Alinari, Derek A West, Melanie E Davis, Ryan B Edwards, Amy J Johnson, Kristie A Blum, Craig C Hofmeister, Michael A Freitas, Mark R Parthun, Dasheng Wang, Amy Lehman, Xiaoli Zhang, David Jarjoura, Samuel K Kulp, Carlo M Croce, Michael R Grever, Ching-Shih Chen, Robert A Baiocchi, John C Byrd
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10941 (2010)
While deacetylase (DAC) inhibitors show promise for the treatment of B-cell malignancies, those introduced to date are weak inhibitors of class I and II DACs or potent inhibitors of class I DAC only, and have shown suboptimal activity or unacceptable
Externí odkaz:
https://doaj.org/article/b8f82372d6bd484e99c19bd6510c448b
Autor:
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown
Externí odkaz:
https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
PDF file - 120K, This is a more detailed discussion of the microarray data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5313a5d5b947a3761207acd62b2be5
https://doi.org/10.1158/1940-6207.22524566.v1
https://doi.org/10.1158/1940-6207.22524566.v1
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
Cells undergoing malignant transformation often exhibit a shift in cellular metabolism from oxidative phosphorylation to glycolysis. This glycolytic shift, called the Warburg effect, provides a mechanistic basis for targeting glycolysis to suppress c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d751ce17aa777387a9eef6b77cba0aa
https://doi.org/10.1158/1940-6207.c.6544310.v1
https://doi.org/10.1158/1940-6207.c.6544310.v1
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
PDF file - 213K, Supplemental Table 1 is a table that lists the average sum of the adjusted lesion scores (SALS) for each lobe of the prostate, as well as the average score for the most severe and most common lesion in each lobe. Supplemental tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067f1e3cde41b7351989c36780f8662
https://doi.org/10.1158/1940-6207.22524563.v1
https://doi.org/10.1158/1940-6207.22524563.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Knockdown of selected genes has modest effects on MOLM13 responses to KPT-9274 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e089686f0f043cf55ed77ea029b663
https://doi.org/10.1158/1078-0432.22484258.v1
https://doi.org/10.1158/1078-0432.22484258.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Purpose:Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (NAMPTi) are currently in development, but may be limited as single-agent therapy due to compound-specific toxicity and cancer metabolic plasticity allowing resistance development. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb93244d92585ade19bc491075e0227
https://doi.org/10.1158/1078-0432.c.6531362.v1
https://doi.org/10.1158/1078-0432.c.6531362.v1