Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Samuel K Kulp"'
Autor:
Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107048- (2024)
High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown
Externí odkaz:
https://doaj.org/article/2e67e650671f4d189b77c2eafc481db4
Autor:
Alyssa Marie M. Castillo, Trang T. Vu, Sophia G. Liva, Min Chen, Zhiliang Xie, Justin Thomas, Bryan Remaily, Yizhen Guo, Uma L. Subrayan, Travis Costa, Timothy H. Helms, Donald J. Irby, Kyeongmin Kim, Dwight H. Owen, Samuel K. Kulp, Thomas A. Mace, Mitch A. Phelps, Christopher C. Coss
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 232-244 (2021)
Abstract Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers to predict responders are
Externí odkaz:
https://doaj.org/article/db94475297f14a02937ba2decc4f78d7
Autor:
Timothy H. Helms, Riley D. Mullins, Jennifer M. Thomas-Ahner, Samuel K. Kulp, Moray J. Campbell, Fabienne Lucas, Nathan Schmidt, Dana M. LeMoine, Surafel Getaneh, Zhiliang Xie, Mitch A. Phelps, Steven K. Clinton, Christopher C. Coss
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatoca
Externí odkaz:
https://doaj.org/article/c25b0208e10b4d27952527a2f7974c56
Autor:
Debasmita Mukherjee, Mallory J. DiVincenzo, Molly Torok, Fouad Choueiry, Rahul J. Kumar, Anna Deems, Jenna L. Miller, Alice Hinton, Connor Geraghty, Jose Angel Maranon, Samuel K. Kulp, Christopher Coss, William E. Carson, Darwin L. Conwell, Phil A. Hart, Jessica L. Cooperstone, Thomas A. Mace
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Chronic pancreatitis (CP) is a fibro-inflammatory syndrome in individuals who develop persistent pathological responses to parenchymal injury or stress. Novel therapeutic or dietary interventions that could lessen inflammation in this diseas
Externí odkaz:
https://doaj.org/article/189cf0125a7b4943bdf76c48d08a9636
Autor:
Sophia G Liva, Yu‐Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi‐Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii‐Saab, Mitchell A Phelps, Ching‐Shih Chen, Christopher C Coss
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-21 (2020)
Abstract No approved therapy exists for cancer‐associated cachexia. The colon‐26 mouse model of cancer cachexia mimics recent late‐stage clinical failures of anabolic anti‐cachexia therapy and was unresponsive to anabolic doses of diverse and
Externí odkaz:
https://doaj.org/article/e590447d2f534e9b86dfa986d39f3eb8
Autor:
Justin Thomas, Molly A. Torok, Kriti Agrawal, Timothy Pfau, Trang T. Vu, Justin Lyberger, Hsiaochi Chang, Alyssa Marie M. Castillo, Min Chen, Bryan Remaily, Kyeongmin Kim, Zhiliang Xie, Mary E. Dillhoff, Samuel K. Kulp, Gregory K. Behbehani, Zobeida Cruz-Monserrate, Latha P. Ganesan, Dwight H. Owen, Mitch A. Phelps, Christopher C. Coss, Thomas A. Mace
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7066 (2022)
The neonatal Fc receptor (FcRn) is responsible for recycling of IgG antibodies and albumin throughout the body. This mechanism has been exploited for pharmaceutic delivery across an array of diseases to either enhance or diminish this function. Monoc
Externí odkaz:
https://doaj.org/article/f0f5d16c774d4cad947053189266bdaf
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
PDF file - 120K, This is a more detailed discussion of the microarray data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5313a5d5b947a3761207acd62b2be5
https://doi.org/10.1158/1940-6207.22524566.v1
https://doi.org/10.1158/1940-6207.22524566.v1
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
Cells undergoing malignant transformation often exhibit a shift in cellular metabolism from oxidative phosphorylation to glycolysis. This glycolytic shift, called the Warburg effect, provides a mechanistic basis for targeting glycolysis to suppress c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d751ce17aa777387a9eef6b77cba0aa
https://doi.org/10.1158/1940-6207.c.6544310.v1
https://doi.org/10.1158/1940-6207.c.6544310.v1
Autor:
Ching-Shih Chen, Samuel K. Kulp, Steven K. Clinton, Tiffany Yang, Dasheng Wang, Brad Bolon, Jennifer M. Thomas-Ahner, Po-Chen Chu, Lisa D. Berman-Booty
PDF file - 213K, Supplemental Table 1 is a table that lists the average sum of the adjusted lesion scores (SALS) for each lobe of the prostate, as well as the average score for the most severe and most common lesion in each lobe. Supplemental tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067f1e3cde41b7351989c36780f8662
https://doi.org/10.1158/1940-6207.22524563.v1
https://doi.org/10.1158/1940-6207.22524563.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Knockdown of selected genes has modest effects on MOLM13 responses to KPT-9274 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e089686f0f043cf55ed77ea029b663
https://doi.org/10.1158/1078-0432.22484258.v1
https://doi.org/10.1158/1078-0432.22484258.v1