Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Samuel K, Sheppard"'
Autor:
Jessica K. Calland, Maiju E. Pesonen, Jai Mehat, Ben Pascoe, David J. Haydon, Jose Lourenco, Barbara Lukasiewicz, Evangelos Mourkas, Matthew D. Hitchings, Roberto M. La Ragione, Philip Hammond, Timothy S. Wallis, Jukka Corander, Samuel K. Sheppard
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Campylobacter is a leading cause of food-borne gastroenteritis worldwide, linked to the consumption of contaminated poultry meat. Targeting this pathogen at source, vaccines for poultry can provide short-term caecal reductions in Campylobact
Externí odkaz:
https://doaj.org/article/8077fca5c18f487b838dfa77bd6a688e
Autor:
Francesca Schiaffino, Craig T. Parker, Maribel Paredes Olortegui, Ben Pascoe, Katia Manzanares Villanueva, Paul F. Garcia Bardales, Evangelos Mourkas, Steven Huynh, Pablo Peñataro Yori, Lucero Romaina Cachique, Hannah K. Gray, Guillermo Salvatierra, Hermann Silva Delgado, Samuel K. Sheppard, Kerry K. Cooper, Margaret N. Kosek
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 36, Iss , Pp 309-318 (2024)
ABSTRACT: Objectives: Antimicrobial resistant (AMR) Campylobacter is a global health threat; however, there is limited information on genomic determinants of resistance in low- and middle-income countries. We evaluated genomic determinants of AMR usi
Externí odkaz:
https://doaj.org/article/fb665d5831704f78bc5b1dde9efc66b4
Autor:
Aidan J. Taylor, Koji Yahara, Ben Pascoe, Seungwon Ko, Leonardos Mageiros, Evangelos Mourkas, Jessica K. Calland, Santeri Puranen, Matthew D. Hitchings, Keith A. Jolley, Carolin M. Kobras, Sion Bayliss, Nicola J. Williams, Arnoud H. M. van Vliet, Julian Parkhill, Martin C. J. Maiden, Jukka Corander, Laurence D. Hurst, Daniel Falush, Paul Keim, Xavier Didelot, David J. Kelly, Samuel K. Sheppard
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (a
Externí odkaz:
https://doaj.org/article/b01240a0b60f44418e276da053e1f0fe
Autor:
Salma W. Elsayed, Reem A. Elghaish, Eman Badr, Shaimaa F. Mouftah, Nehal A. Saif, Iman S. Naga, Ahmed H. Shata, Ben Pascoe, Samuel K. Sheppard, Mohamed Elhadidy
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly evolving pathogen that is frequently associated with outbreaks and sustained epidemics. This study investigated the population structure, resistome, virulome, and the
Externí odkaz:
https://doaj.org/article/45f663a8e8a84454bc4aa1b4c0b3f54d
Autor:
Biel Garcias, Mayra Alejandra Flores, Mercedes Fernández, William Monteith, Ben Pascoe, Samuel K. Sheppard, Marga Martín, Martí Cortey, Laila Darwich
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 759 (2024)
Antimicrobial resistance (AMR) is a significant global health threat, with multidrug-resistant (MDR) bacterial clones becoming a major concern. Polymyxins, especially colistin, have reemerged as last-resort treatments for MDR Gram-negative infections
Externí odkaz:
https://doaj.org/article/e6567c7add6a4c9c83a3f0f1859fe962
Autor:
Sabrina Hepner, Konstantin Kuleshov, Ave Tooming-Kunderud, Nikolas Alig, Alexander Gofton, Sherwood Casjens, Robert E. Rollins, Alexandra Dangel, Evangelos Mourkas, Samuel K. Sheppard, Andreas Wieser, Johannes Hübner, Andreas Sing, Volker Fingerle, Gabriele Margos
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Bacteria of the Borrelia burgdorferi sensu lato (s.l.) complex can cause Lyme borreliosis. Different B. burgdorferi s.l. genospecies vary in their host and vector associations and human pathogenicity but the genetic basis for thes
Externí odkaz:
https://doaj.org/article/537dae20a7534ae0a058a30caaee0e78
Autor:
Claire A. Woodall, Ashley Hammond, David Cleary, Andrew Preston, Peter Muir, Ben Pascoe, Samuel K. Sheppard, Alastair D. Hay
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18610- (2023)
We conducted a feasibility cohort study which aimed to recruit and retain adults from the community to collect saliva (oral) and stool (gut) samples at three time points, at the start of the study (baseline), during a respiratory tract infection (RTI
Externí odkaz:
https://doaj.org/article/d65189be1fe6400e864807371bc65a44
Autor:
Harry A. Thorpe, Elise Tourrette, Koji Yahara, Filipa F. Vale, Siqi Liu, Mónica Oleastro, Teresa Alarcon, Tsachi-Tsadok Perets, Saeid Latifi-Navid, Yoshio Yamaoka, Beatriz Martinez-Gonzalez, Ioannis Karayiannis, Timokratis Karamitros, Dionyssios N. Sgouras, Wael Elamin, Ben Pascoe, Samuel K. Sheppard, Jukka Ronkainen, Pertti Aro, Lars Engstrand, Lars Agreus, Sebastian Suerbaum, Kaisa Thorell, Daniel Falush
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Helicobacter pylori is a major human pathogen whose population structure is similar to that of its host. Here, the authors show that H. pylori has repeatedly spread out of Africa recently, replacing deleterious variants that accumulated during the or
Externí odkaz:
https://doaj.org/article/54287d44e6a344f886d3d297e6a9f657
Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans
Autor:
Stephanie Peters, Ben Pascoe, Zuowei Wu, Sion C. Bayliss, Ximin Zeng, Adam Edwinson, Sakteesh Veerabadhran-Gurunathan, Selina Jawahir, Jessica K. Calland, Evangelos Mourkas, Robin Patel, Terra Wiens, Marijke Decuir, David Boxrud, Kirk Smith, Craig T. Parker, Gianrico Farrugia, Qijing Zhang, Samuel K. Sheppard, Madhusudan Grover
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Stephanie Peters, Ben Pascoe, et al. use whole-genome sequencing and phenotypic analysis of clinical strains from patients to identify potential genetic factors involved in irritable bowel syndrome resulting from Campylobacter jejuni infection. Their
Externí odkaz:
https://doaj.org/article/d22cc24a83004456be1c4f98ca2c592e
Autor:
Keira Tucker, Leonardos Mageiros, Alno Carstens, Ludwig Bröcker, Edward Archer, Katrin Smith, Evangelos Mourkas, Ben Pascoe, Daan Nel, Guillaume Meric, Samuel K. Sheppard, Barbara Kasprzyk-Hordern, Marelize Botes, Edward J. Feil, Gideon Wolfaardt
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT With increasing emergence of antimicrobial resistant bacteria (ARB) and the risk this poses to public health, there are growing concerns regarding water pollution contributing to the spread of antimicrobial resistance (AMR) through inadequat
Externí odkaz:
https://doaj.org/article/ede7518ff8ba49389a417c742097d9a5