Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Samuel K, Kwofie"'
Autor:
Patrick O. Sakyi, Selina A. Saah, Prince Baddor, Jacqueline Adu Gyamfi, Nathaniel O. Boadi, Emmanuel Broni, Whelton A. Miller III, Paul Q. Somiah, Samuel K. Kwofie
Publikováno v:
Scientific African, Vol 25, Iss , Pp e02264- (2024)
Approximately 60 % of men globally over the age of 50 experience a diminished quality of life as a result of benign prostatic hyperplasia (BPH). Consequently, while the national direct cost for managing BPH is hovering around $4 billion in the USA, t
Externí odkaz:
https://doaj.org/article/21da05d7ac324a52b649830e513cd634
Autor:
Emmanuel Broni, Carolyn N. Ashley, Miriam Velazquez, Patrick O. Sakyi, Samuel K. Kwofie, Whelton A. Miller
Publikováno v:
Computation, Vol 12, Iss 6, p 112 (2024)
Cervical cancer is the fourth most diagnosed cancer and the fourth leading cause of cancer death in women globally. Its onset and progression have been attributed to high-risk human papillomavirus (HPV) types, especially 16 and 18, while the Epstein
Externí odkaz:
https://doaj.org/article/e6dc6a9dce4c441baadd80d8051271bc
Autor:
Moses N. Arthur, Kristeen Bebla, Emmanuel Broni, Carolyn Ashley, Miriam Velazquez, Xianin Hua, Ravi Radhakrishnan, Samuel K. Kwofie, Whelton A. Miller
Publikováno v:
Computation, Vol 12, Iss 1, p 3 (2023)
The prognosis of mixed-lineage leukemia (MLL) has remained a significant health concern, especially for infants. The minimal treatments available for this aggressive type of leukemia has been an ongoing problem. Chromosomal translocations of the KMT2
Externí odkaz:
https://doaj.org/article/bffe6fc9bb894e218cfe1010b92813a5
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 4, Pp 1434-1451 (2022)
The role of the microbiota–gut–brain (MGB) axis in mood regulation and depression treatment has gained attention in recent years, as evidenced by the growing number of animal and human studies that have reported the anti-depressive and associated
Externí odkaz:
https://doaj.org/article/288bf2d276f44f2db1bb0a98e0ba3070
Autor:
Cynthia A. Adinortey, Gabriel B. Kwarko, Russell Koranteng, Daniel Boison, Issaka Obuaba, Michael D. Wilson, Samuel K. Kwofie
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 963-987 (2022)
Diabetes mellitus is a disorder characterized by higher levels of blood glucose due to impaired insulin mechanisms. Alpha glucosidase is a critical drug target implicated in the mechanisms of diabetes mellitus and its inhibition controls hyperglycemi
Externí odkaz:
https://doaj.org/article/d151008eaeaa44928012e74138225010
Autor:
Patrick O. Sakyi, Emmanuel Broni, Richard K. Amewu, Whelton A. Miller, III, Michael D. Wilson, Samuel K. Kwofie
Publikováno v:
Informatics in Medicine Unlocked, Vol 37, Iss , Pp 101162- (2023)
The mortalities and morbidities of leishmaniasis are high and the disease is under reported globally. The absence of vaccines coupled with chemotherapeutic challenges including chemoresistance, scarcity and toxicity have made the fight against leishm
Externí odkaz:
https://doaj.org/article/c0579ab52ccb4dad8f17ed73297561a9
Autor:
Emmanuel Broni, Carolyn Ashley, Miriam Velazquez, Sufia Khan, Andrew Striegel, Patrick O. Sakyi, Saqib Peracha, Kristeen Bebla, Monsheel Sodhi, Samuel K. Kwofie, Adesanya Ademokunwa, Whelton A. Miller
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12612 (2023)
Adenosine deaminase acting on RNA 2 (ADAR2) is an important enzyme involved in RNA editing processes, particularly in the conversion of adenosine to inosine in RNA molecules. Dysregulation of ADAR2 activity has been implicated in various diseases, in
Externí odkaz:
https://doaj.org/article/74de81b84a1a45048986f3cab6e3d084
Autor:
Seth Osei Asiedu, Yash Gupta, Vlad Nicolaescu, Haley Gula, Thomas R. Caulfield, Ravi Durvasula, Prakasha Kempaiah, Samuel K. Kwofie, Michael D. Wilson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7151 (2023)
We have previously shown computationally that Mycolactone (MLN), a toxin produced by Mycobacterium ulcerans, strongly binds to Munc18b and other proteins, presumably blocking degranulation and exocytosis of blood platelets and mast cells. We investig
Externí odkaz:
https://doaj.org/article/9072fccb32d7427ea6459101183283f0
Autor:
Emmanuel Broni, Andrew Striegel, Carolyn Ashley, Patrick O. Sakyi, Saqib Peracha, Miriam Velazquez, Kristeen Bebla, Monsheel Sodhi, Samuel K. Kwofie, Adesanya Ademokunwa, Sufia Khan, Whelton A. Miller
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6795 (2023)
Altered RNA editing has been linked to several neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, in addition to depression, schizophrenia, some cancers, viral infections and autoimmune disorders. The
Externí odkaz:
https://doaj.org/article/abd705391bd240b0b259525d5998c491
Autor:
Emmanuel Broni, Carolyn Ashley, Joseph Adams, Hammond Manu, Ebenezer Aikins, Mary Okom, Whelton A. Miller, Michael D. Wilson, Samuel K. Kwofie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6298 (2023)
The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in primates. However, there are no regulatorily approved drugs against the Ebola virus disease (EVD). The highly virulent and lethal nature of EVD highlights the n
Externí odkaz:
https://doaj.org/article/d08c92cc6f904b869206df1204abab1f