Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel James Brake"'
Autor:
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug, Josie Larby, Ashutosh Hardikar, Gurpreet K. Singhera, Tillie L. Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCOPD is a common disease characterized by respiratory airflow obstruction. TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving epithelial mesenchymal transition (EMT).MethodsWe investigated TGF-β1 signalling
Externí odkaz:
https://doaj.org/article/1785ac62c9de46619da72af6e7aa262d
Autor:
Surajit Dey, Wenying Lu, Heinrich C. Weber, Sally Young, Josie Larby, Collin Chia, Greg Haug, Samuel James Brake, Stephen Myers, Archana Vijay Gaikwad, Prem Bhattarai, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(4)
Management of patients with asthma COPD overlap (ACO) is clinically challenging due to insufficient evidence of pathological changes in these patients. In this cross-sectional study, we evaluated airway remodeling in endobronchial biopsies from a tot
Autor:
Wenying Lu, Mathew Suji Eapen, Gurpreet Kaur Singhera, James Markos, Greg Haug, Collin Chia, Josie Larby, Samuel James Brake, Glen P. Westall, Jade Jaffar, Rama Satyanarayana Raju Kalidhindi, Nimesha De Fonseka, Venkatachalem Sathish, Tillie L. Hackett, Sukhwinder Singh Sohal
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 777, p 777 (2022)
Journal of Clinical Medicine; Volume 11; Issue 3; Pages: 777
Journal of Clinical Medicine; Volume 11; Issue 3; Pages: 777
We previously reported higher ACE2 levels in smokers and patients with COPD. The current study investigates if patients with interstitial lung diseases (ILDs) such as IPF and LAM have elevated ACE2, TMPRSS2, and Furin levels, increasing their risk fo
Autor:
James Markos, Heinrich C. Weber, Samuel James Brake, Josie Larby, Mathew Suji Eapen, Greg Haug, Peter A. B. Wark, Wenying Lu, Surajit Dey, Archana Vijay Gaikwad, Stephen Myers, Prem Bhattarai, Collin Chia, Sukhwinder Singh Sohal
Publikováno v:
Molecular pathology and functional genomics.
Background: Management of ACO is clinically challenging due to insufficient evidence on pathological changes in these patients. Aim: To evaluate large airway remodelling changes in patients with ACO compared to asthma, COPD ex-smokers (ES) and curren
Autor:
Prem Bhattarai, Jade Jaffar, Collin Chia, Tillie-Louise Hackett, Mathew Suji Eapen, Gurpreet K. Singhera, Sukhwinder Singh Sohal, Archana Vijay Gaikwad, Greg Haug, Surajit Dey, Samuel James Brake, Josie Larby, James Markos, Glen P. Westall, Wenying Lu, Stephen Myers
Publikováno v:
Molecular pathology and functional genomics.
Aim: To perform a comprehensive quantitative analysis of pulmonary arterial changes in IPF. Methods: Movat’s Pentachrome staining was conducted on lung tissue from patients with IPF (n=13) and healthy controls (HC; n=11). Based on position and size
Autor:
Wenying Lu, Tillie L. Hackett, Kielan Darcy McAlinden, Josie Larby, Greg Haug, Gurpreet K. Singhera, Samuel James Brake, Mathew Suji Eapen, Ashutosh Hardikar, James Markos, Heinrich C. Weber, Collin Chia, Sukhwinder Singh Sohal
Publikováno v:
Molecular pathology and functional genomics.
Aim: To perform detailed tissue analysis of SARS-CoV-2 adhesion sites in surgically resected small airway tissue. Methods: This study included 16 patients with COPD, of which 8 were current smokers with COPD (COPD-CS) and 8 ex-smokers with COPD (COPD
Autor:
Mathew Suji Eapen, Pritam Saha, Samuel James Brake, Sukhwinder Singh Sohal, Sopan B Shinde, Ashish Dangi, V.G.M. Naidu, Pawan K. Sharma, Ebin Johny
Publikováno v:
Toxics, Vol 6, Iss 4, p 68 (2018)
Toxics
Toxics
Air pollution has become an emerging invisible killer in recent years and is a major cause of morbidity and mortality globally. More than 90% of the world’s children breathe toxic air every day. India is among the top ten most highly polluted count
Autor:
Kielan Darcy McAlinden, Mathew Suji Eapen, Samuel James Brake, Sukhwinder Singh Sohal, Kathryn Barnsley, Wenying Lu
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 3, p 841 (2020)
Journal of Clinical Medicine, 9(3):841
Journal of Clinical Medicine
Journal of Clinical Medicine, 9(3):841
Journal of Clinical Medicine
The epicenter of the original outbreak in China has high male smoking rates of around 50%, and early reported death rates have an emphasis on older males, therefore the likelihood of smokers being overrepresented in fatalities is high. In Iran, China