An inter‐species protein–protein interaction network across vast evolutionary distance

Autor: Quan Zhong, Samuel J Pevzner, Tong Hao, Yang Wang, Roberto Mosca, Jörg Menche, Mikko Taipale, Murat Taşan, Changyu Fan, Xinping Yang, Patrick Haley, Ryan R Murray, Flora Mer, Fana Gebreab, Stanley Tam, Andrew MacWilliams, Amélie Dricot, Patrick Reichert, Balaji Santhanam, Lila Ghamsari, Michael A Calderwood, Thomas Rolland, Benoit Charloteaux, Susan Lindquist, Albert‐László Barabási, David E Hill, Patrick Aloy, Michael E Cusick, Yu Xia, Frederick P Roth, Marc Vidal

Publikováno v: Molecular Systems Biology, Vol 12, Iss 4, Pp 1-19 (2016)

Abstract In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional in

Externí odkaz: https://doaj.org/article/8947e4a722804e5f9ef09601ac31c1ba

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

Autor: Dawit Balcha, Lila Ghamsari, Andrew MacWilliams, Aaron Richardson, Alyce A. Chen, Song Yi, Benoit Charloteaux, Tong Hao, Jasmin Coulombe-Huntington, Kerstin Spirohn, Shelly A. Trigg, Bridget E. Begg, Quan Zhong, Marc Vidal, Brenda J. Andrews, Frederick P. Roth, Yu Xia, Michael Costanzo, Guihong Tan, David E. Hill, Gloria M. Sheynkman, Yun A. Shen, Samuel J. Pevzner, Nidhi Sahni, Shuli Kang, Michael A. Calderwood, Kourosh Salehi-Ashtiani, Maria D. Rodriguez, Song Sun, Lilia M. Iakoucheva, Patrick Aloy, Ryan R. Murray, Fan Yang, Xinping Yang, Xianghong Jasmine Zhou, Charles Boone, Stanley Tam, Miquel Duran-Frigola

Publikováno v: Cell. 164(4):805-817

While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202ca2ee2a9f6fc92cf12f6992fc889c

Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

Autor: M. Shahid Mukhtar, Lila Ghamsari, Huaming Chen, Jeffery L. Dangl, Matija Dreze, Marc Vidal, Mike Boxem, Viviana Romero, Yijian He, Petra Epple, Nathan A. McDonald, Matthew M. Poulin, Christopher J. Harbort, Lantian Gai, Dario Monachello, Frederick P. Roth, Joseph R. Ecker, Jim Beynon, Jens Steinbrenner, Fana Gebreab, Anne-Ruxandra Carvunis, Marc T. Nishimura, Bryan J. Gutierrez, David E. Hill, Tong Hao, Pascal Braun, Mary Galli, Susan E. Donovan, Jonathan D. Moore, Jean Vandenhaute, Samuel J. Pevzner, Balaji Santhanam, Murat Tasan, Stanley Tam

Publikováno v: Science
Science, American Association for the Advancement of Science, 2011, 333 (6042), pp.596-601. ⟨10.1126/science.1203659⟩
Science, 2011, 333 (6042), pp.596-601. ⟨10.1126/science.1203659⟩

International audience; Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eba2d6925b241319612e6ba75ba543d
https://doi.org/10.1126/science.1203659

Evidence for Network Evolution in an Arabidopsis Interactome Map

Autor: Viviana Romero, Jeffery L. Dangl, Jyotika Mirchandani, M. Shahid Mukhtar, Eric Olivares, Samuel J. Pevzner, Gopalakrishna Ramaswamy, Jonathan D. Chesnut, Geetha M. Swamilingiah, Thomas Rolland, Doreen Ware, William Spooner, Tijana Milenkovic, Edward A. Rietman, Huaming Chen, Rosa Cheuk Kim, Pascal Braun, Frederick P. Roth, Lantian Gai, Matthew M. Poulin, Gourab Ghoshal, Robert J. Schmitz, Balaji Santhanam, Stacy Wu, Murat Tasan, Paul Shinn, Michael E. Cusick, Danielle Byrdsong, Marc Vidal, Andrew MacWilliams, Selma Waaijers, Chris de los Reyes, Jonathan D. Moore, Uday Matrubutham, Fana Gebreab, Patrick Reichert, Claire Lurin, Dario Monachello, Changyu Fan, Jean Vandenhaute, Padmavathi Balumuri, Matija Dreze, Vanessa Bautista, Yong-Yeol Ahn, Albert-László Barabási, Natasa Przulj, Benoit Charloteaux, Joshua C. Stein, Tong Hao, Mary Galli, Joseph R. Ecker, Junshi Yazaki, Amélie Dricot, Suswapna Patnaik, Melissa Duarte, Sabrina Rabello, Evan M. Weiner, Anne-Ruxandra Carvunis, Christopher Kim, Rosa Quan, Patrick Gilles, Bryan J. Gutierrez, David E. Hill, Stanley Tam

Publikováno v: Science
Science, American Association for the Advancement of Science, 2011, 333 (6042), pp.601-607. ⟨10.1126/science.1203877⟩
Science, 2011, 333 (6042), pp.601-607. ⟨10.1126/science.1203877⟩

International audience; Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5f4fbd0582df24fad156641206a9e9
https://hal.inrae.fr/hal-02651738