Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

Autor: M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114614- (2024)

Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain

Externí odkaz: https://doaj.org/article/cd2c68f5fde8412d87e766b66f097032

Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]

Autor: M.A. Bangash, Sascha R.A. Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija ter Heegde, Abdella M. Habib, Vanessa Pereira, Jane E. Sexton, Edward C. Emery, Shengnan Li, Ana P. Luiz, Janka Erdos, Samuel J. Gossage, Jing Zhao, James J. Cox, John N. Wood

Publikováno v: Wellcome Open Research, Vol 3 (2018)

Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres

Externí odkaz: https://doaj.org/article/321b7fa64d604323a2606b1a61824c71

Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions

Autor: Sascha R.A. Alles, Janka Erdos, Queensta Millet, Freija Ter Heegde, Shengnan Li, Vanessa Pereira, Jane E. Sexton, John N. Wood, Edward C. Emery, M A Bangash, Jing Zhao, Abdella M. Habib, Ana P. Luiz, Shafaq Sikandar, Samuel J. Gossage, Larissa de Clauser, Sonia Santana-Varela, James J. Cox

Publikováno v: Wellcome Open Research
Bangash, M A, Alles, S R A, Santana-varela, S, Millet, Q, Sikandar, S, De Clauser, L, Ter Heegde, F, Habib, A M, Pereira, V, Sexton, J E, Emery, E C, Li, S, Luiz, A P, Erdos, J, Gossage, S J, Zhao, J, Cox, J J & Wood, J N 2018, ' Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions ', Wellcome Open Research, vol. 3, pp. 78 . https://doi.org/10.12688/wellcomeopenres.14641.1

Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3818eb43e1c523e6ad8ef8c8cc7ad21

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

Autor: Eric Jacobi, Charles A. Greer, Jan Weiss, Philippe Zizzari, Samuel J. Gossage, Trese Leinders-Zufall, Bernd Bufe, Bernhard Schick, Frank Zufall, Martina Pyrski, John N. Wood, Vivienne Willnecker, C. Geoffrey Woods

Publikováno v: Nature. 472(7342)

Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Na(v)1.7, causes a congenital inability to experience pain in humans. Here we show that Na(v)1.7 is not only necessary for pain sensation but is also an essential requireme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c9dfaef945127bbb9909f2a8c6bc93
https://pubmed.ncbi.nlm.nih.gov/21490662