Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel J Windross"'
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Thaneas Prabakaran, Anne Troldborg, Sarinya Kumpunya, Isara Alee, Emilija Marinković, Samuel J. Windross, Ramya Nandakumar, Ryo Narita, Bao-cun Zhang, Mikkel Carstensen, Pichpisith Vejvisithsakul, Mikkel H.S. Marqvorsen, Marie B. Iversen, Christian K. Holm, Lars J. Østergaard, Finn Skou Pedersen, Trairak Pisitkun, Rayk Behrendt, Prapaporn Pisitkun, Søren R. Paludan
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103314- (2021)
Background: Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases are characterized by elevated IFN-I, including systemic lupus erythematosus (lupu
Externí odkaz:
https://doaj.org/article/da5f1e87afd543a2bd603e12507fe509
Autor:
Felix Wottawa, Björn Becker, Mohamed Bakr, Lisa Mayr, Julia Kugler, Samuel J Windross, Laura Neises, Silke van den Bossche, Nassim Kakavand, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie Stengel, Go Ito, Olivia Coleman, Christian Jaeger, Eric Koncina, Elisabeth Letellier, Dirk Haller, Søren R Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon Adolph, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Mucosal cytomegalovirus (CMV) infection represents a leading cause for complicated disease behaviour and proctocolectomy in patients with inflammatory bowel disease (IBD). Using a genetic loss-of-function mouse model of the hypomorphic IBD risk gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4008398ae3c7b1bd1de7d7b721aea7c3
https://doi.org/10.1101/2022.05.17.492340
https://doi.org/10.1101/2022.05.17.492340
Autor:
Chiranjeevi Bodda, Søren B. Jensen, Carsten Scavenius, Anne Troldborg, Christine Doucet, Cheng long Sun, Ramya Nandakumar, Anders Laustsen, Thaneas Prabakaran, Zong liang Gao, Samuel J. Windross, Harald Stenmark, Zheng Guo, Line S. Reinert, Sonia Assil, Rune Hartmann, Søren R. Paludan, Jinrong Huang, Martin K. Thomsen, Yan Zhang, Ryo Narita, Jan J. Enghild, Bao cun Zhang, Zhijian J. Chen, Raphaela Goldbach-Mansky, Takeshi Noda, David Olagnier, Rasmus O. Bak, Cong gang Zhang, Martin F. Berthelsen, Yujia Cai
Publikováno v:
Nature immunology
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b3d24834418261f43505fb46cd4e24
http://europepmc.org/articles/PMC7610351
http://europepmc.org/articles/PMC7610351
Autor:
Marie B. Iversen, Finn Skou Pedersen, Bao-Cun Zhang, Trairak Pisitkun, Emilija Marinkovic, Christian K. Holm, Anne Troldborg, Ryo Narita, Mikkel H. S. Marqvorsen, Isara Alee, Pichpisith Vejvisithsakul, Mikkel Carstensen, Lars Østergaard, Thaneas Prabakaran, Rayk Behrendt, Samuel J. Windross, Sarinya Kumpunya, Prapaporn Pisitkun, Ramya Nandakumar, Søren R. Paludan
Publikováno v:
EBioMedicine
Prabakaran, T, Troldborg, A, Kumpunya, S, Alee, I, Marinković, E, Windross, S J, Nandakumar, R, Narita, R, Zhang, B-C, Carstensen, M, Vejvisithsakul, P, Marqvorsen, M H S, Iversen, M B, Holm, C K, Østergaard, L J, Pedersen, F S, Pisitkun, T, Behrendt, R, Pisitkun, P & Paludan, S R 2021, ' A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology ', EBioMedicine, vol. 66, 103314 . https://doi.org/10.1016/j.ebiom.2021.103314
EBioMedicine, Vol 66, Iss, Pp 103314-(2021)
Prabakaran, T, Troldborg, A, Kumpunya, S, Alee, I, Marinković, E, Windross, S J, Nandakumar, R, Narita, R, Zhang, B-C, Carstensen, M, Vejvisithsakul, P, Marqvorsen, M H S, Iversen, M B, Holm, C K, Østergaard, L J, Pedersen, F S, Pisitkun, T, Behrendt, R, Pisitkun, P & Paludan, S R 2021, ' A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology ', EBioMedicine, vol. 66, 103314 . https://doi.org/10.1016/j.ebiom.2021.103314
EBioMedicine, Vol 66, Iss, Pp 103314-(2021)
BACKGROUND: Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases are characterized by elevated IFN-I, including systemic lupus erythematosus (lupu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb22d010631ad18540617433d5c8868
Autor:
Martin F. Berthelsen, Yan Zhang, Ryo Narita, Sonia Assil, Carsten Scavenius, Raphaela Goldbach-Mansky, Rasmus O. Bak, David Olagnier, Zhijian J. Chen, Jinrong Huang, Søren R. Paludan, Takeshi Noda, Samuel J. Windross, Harald Stenmark, Thaneas Prabakaran, Yujia Cai, Rune Hartmann, Line S. Reinert, Zheng Guo, Bao cun Zhang, Martin K. Thomsen, Anders Laustsen, Jan J. Enghild, Ramya Nandakumar, Cheng long Sun, Zong liang Gao, Christine Doucet, Chiranjeevi Bodda, Anne Troldborg, Søren B. Jensen, Cong gang Zhang
Publikováno v:
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' Author Correction : STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0803-5
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bb3e3db1d60ebe80ca5c2633ceab2c
https://doi.org/10.1038/s41590-020-0803-5
https://doi.org/10.1038/s41590-020-0803-5
Publikováno v:
Nandakumar, R, Windross, S J & Paludan, S R 2019, Intercellular communication in the innate immune system through the cGAS-STING pathway . in J Sohn (ed.), DNA Sensors and Inflammasomes . Elsevier, Methods in Enzymology, vol. 625, pp. 1-11 . https://doi.org/10.1016/bs.mie.2019.07.007
Type I interferons (IFN alpha/beta) are pivotal to anti-viral defense. Although an absolute requirement for viral clearance, the presence of IFN in high doses sustained over time has been implicated to be the underlying cause of clinical outcomes suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef17ba46b42ad16e1a7e9101494a3a17
https://doi.org/10.1016/bs.mie.2019.07.007
https://doi.org/10.1016/bs.mie.2019.07.007
Genome-editing with CRISPR has emerged as a technology with broad therapeutic potential. However, it is unclear whether CRISPR will elicit innate immune responses, which could impact both positively and negatively on the desired therapeutic effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1995568fcb0dcc92cf77758223e0ff6e
https://doi.org/10.1101/282558
https://doi.org/10.1101/282558