Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Samuel J Rodgers"'
Autor:
Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individu
Externí odkaz:
https://doaj.org/article/b82edde0750c4c3ea2517f10c34927f4
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endoso
Externí odkaz:
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characteri
Externí odkaz:
https://doaj.org/article/829dfbdf5cfe459dbb5485f5449b9504
Autor:
Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson, Roger J. Daly
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator o
Externí odkaz:
https://doaj.org/article/16b94020768b4b0886330aa70dd0da0d
Autor:
Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina A. Mitchell, Meagan J. McGrath
Publikováno v:
Autophagy. :1-18
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy function, a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bfd050106eeb659a90ed23db3ca28a
https://doi.org/10.1080/15548627.2022.2128019
https://doi.org/10.1080/15548627.2022.2128019
Publikováno v:
Cancers. 15(1)
The majority of breast cancers are estrogen receptor-positive (ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9127ab681a723193e66d17b66571122
https://pubmed.ncbi.nlm.nih.gov/36612130
https://pubmed.ncbi.nlm.nih.gov/36612130
Publikováno v:
Autophagy.
Macroautophagy/autophagy occurs basally under nutrient-rich conditions in most mammalian cells, contributing to protein and organelle quality control, and protection against aging and neurodegeneration. During autophagy, lysosomes are heavily utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d18c7a6049fe336d2f0b93b72723f303
https://pubmed.ncbi.nlm.nih.gov/36103410
https://pubmed.ncbi.nlm.nih.gov/36103410
Autor:
Samuel J Rodgers, Emily I Jones, Senthil Arumugam, Sabryn A Hamila, Jill Danne, Rajendra Gurung, Matthew J Eramo, Randini Nanayakkara, Georg Ramm, Meagan J McGrath, Christina A Mitchell
Publikováno v:
The EMBO Journal. 41
Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co-ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient-rich conditions, is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600e78f8e92a9e85bf84fc9297ea0175
https://doi.org/10.15252/embj.2021110398
https://doi.org/10.15252/embj.2021110398
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e2bc82108595261d2a16543c76a05
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Publikováno v:
Mol Cell Oncol
AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER(+)) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670d2aeae3d61099562734ac435a3e09
https://doi.org/10.1080/23723556.2021.1954470
https://doi.org/10.1080/23723556.2021.1954470