Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Samuel J H Hinshaw"'
Autor:
Wambui S Wandu, Cuiyan Tan, Osato Ogbeifun, Barbara P Vistica, Guangpu Shi, Samuel J H Hinshaw, Chengsong Xie, Xi Chen, Dennis M Klinman, Huaibin Cai, Igal Gery
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128906 (2015)
Mutations in LRRK2 are related to certain forms of Parkinson's disease and, possibly, to the pathogenesis of Crohn's disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in lymphoid cells an
Externí odkaz:
https://doaj.org/article/d5759c03978d4c24a5912486766dcee2
Autor:
Samuel J. H. Hinshaw, Robert E. W. Hancock, Christopher D. Pascoe, Aruni Jha, Andrew J. Halayko, Reza Falsafi, Sujata Basu, Neeloffer Mookherjee, Thomas H. Mahood, Amy S. Lee
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The abundance of lipopolysaccharide (LPS) in house dust mite (HDM) preparations is broad and mirrors the variability seen in the homes of people with asthma. LPS in commercially available stocks ranges from 31 to 5,2000 endotoxin units. The influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e684d67ccf55df5684a37fbcd1b85af9
https://europepmc.org/articles/PMC7347269/
https://europepmc.org/articles/PMC7347269/
Publikováno v:
Bioinformatics (Oxford, England). 34(18)
Summary Here, we present MetaBridge, a tool that collates protein interactors (curated metabolite-enzyme interactions) that influence the levels of specific metabolites including both biosynthetic and degradative enzymes. This enables network-based i
Autor:
Osato Ogbeifun, Samuel J. H. Hinshaw, Lindsey F. Nugent, Ignacio R. Rodriguez, Igal Gery, Siqi Chen, Wambui S. Wandu, Arvydas Maminishkis, Guangpu Shi
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:1658-1664
PURPOSE The inflammatory process plays a major role in the pathogenesis of AMD, and recent data indicate the involvement of inflammasomes. Inflammasomes are intracellular structures that trigger inflammation by producing mature interleukin-(IL)-1β a
Autor:
Rachel R. Caspi, Wambui S. Wandu, Lin Lu, Jianfei Yang, Mercedes Lobera, Igal Gery, Guangpu Shi, Biying Xu, So Jin Bing, Cancan Lyu, Samuel J. H. Hinshaw
Publikováno v:
European journal of immunology. 48(11)
Experimental autoimmune uveitis (EAU), an animal model for severe intraocular inflammatory eye diseases, is mediated by both Th1 and Th17 cells. Here, we examined the capacity of TMP778, a selective inhibitor of RORγt, to inhibit the development of
Autor:
Samuel J. H. Hinshaw, Guangpu Shi, Igal Gery, Chan Zhao, Meifen Zhang, Cuiyan Tan, Barbara P. Vistica, Wambui S. Wandu
Publikováno v:
Cellular Immunology. 290:179-184
Regulatory T-cells (Tregs) are responsible for homeostasis of the immune system, as well as for inhibition of pathogenic autoimmune processes. Induced-(i)-Tregs, can be generated in vitro by activation of CD4 cells in the presence of TGF-β. A common
Autor:
Igal Gery, Guangpu Shi, Yichao Li, Cancan Lyu, Osato Ogbeifun, Haohua Qian, Wambui S. Wandu, Samuel J. H. Hinshaw
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Digoxin, a major medication for heart disease, was recently reported to have immunosuppressive capacity. Here, we determined the immunosuppressive capacity of digoxin on the development of experimental autoimmune uveitis (EAU) and on related
Autor:
Xi Chen, Huaibin Cai, Osato Ogbeifun, Cuiyan Tan, Guangpu Shi, Barbara P. Vistica, Chengsong Xie, Wambui S. Wandu, Dennis M. Klinman, Samuel J. H. Hinshaw, Igal Gery
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128906 (2015)
PLoS ONE
PLoS ONE
Background Mutations in LRRK2 are related to certain forms of Parkinson’s disease and, possibly, to the pathogenesis of Crohn’s disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in ly
Autor:
Samuel J. H. Hinshaw, Guangpu Shi, Barbara P. Vistica, Lindsey F. Nugent, Osato Ogbeifun, Igal Gery
Publikováno v:
Investigative ophthalmologyvisual science. 54(12)
Purpose Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity