Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Samuel J Bose"'
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Autor:
Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A. B. Burton
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP3 signalling has been linked to the
Externí odkaz:
https://doaj.org/article/29468d17e8584ec7a7b1825bc001c2d9
Autor:
Thamali Ayagama, Samuel J. Bose, Rebecca A. Capel, David A. Priestman, Georgina Berridge, Roman Fischer, Antony Galione, Frances M. Platt, Holger Kramer, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102949- (2021)
Summary: The importance of lysosomes in cardiac physiology and pathology is well established, and evidence for roles in calcium signaling is emerging. We describe a label-free proteomics method suitable for small cardiac tissue biopsies based on dens
Externí odkaz:
https://doaj.org/article/89182a514c6548768b6697ff55f84605
Autor:
Rebecca-Ann B. Burton, Jakub Tomek, Christina M. Ambrosi, Hege E. Larsen, Amy R. Sharkey, Rebecca A. Capel, Alexander D. Corbett, Samuel Bilton, Aleksandra Klimas, Guy Stephens, Maegan Cremer, Samuel J. Bose, Dan Li, Giuseppe Gallone, Neil Herring, Edward O. Mann, Abhinav Kumar, Holger Kramer, Emilia Entcheva, David J. Paterson, Gil Bub
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101334- (2020)
Summary: Cardiac stimulation via sympathetic neurons can potentially trigger arrhythmias. We present approaches to study neuron-cardiomyocyte interactions involving optogenetic selective probing and all-optical electrophysiology to measure activity i
Externí odkaz:
https://doaj.org/article/1bf96b0e36b34140aa42ebc9b7826702
Autor:
Charalampos Sigalas, Maegan Cremer, Annika Winbo, Samuel J. Bose, Jesse L. Ashton, Gil Bub, Johanna M. Montgomery, Rebecca A. B. Burton
Publikováno v:
Royal Society Open Science, Vol 7, Iss 6 (2020)
Interactions along the neuro-cardiac axis are being explored with regard to their involvement in cardiac diseases, including catecholaminergic polymorphic ventricular tachycardia, hypertension, atrial fibrillation, long QT syndrome and sudden death i
Externí odkaz:
https://doaj.org/article/56f283baf59c4d36bf2f09e82c83306c
Autor:
Thamali Ayagama, Philip D Charles, Samuel J Bose, Barry Boland, David A Priestman, Daniel Aston, Georgina Berridge, Roman Fisher, Adam P Cribbs, Qianqian Song, Gary R Mirams, Lisa Heather, Antony Galione, Neil Herring, Ulrich Schotten, Rebecca A Capel, Frances M Platt, Holger Krame, Sander Verheule, Rebecca AB Burton
SummaryEndolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL help facilitate elimination of damaged membrane and cytosolic proteins, protein aggregates, membranous organelles and also play an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7d6c55db8b271c1c4a8ef5f88e1cd3
https://doi.org/10.1101/2023.03.10.532119
https://doi.org/10.1101/2023.03.10.532119
Autor:
Zhaozheng Meng, Rebecca A Capel, Samuel J Bose, Erik Bosch, Sophia de Jong, Robert Planque, Antony Galione, Rebecca AB Burton, Alfonso Bueno-Orovio
Spontaneous calcium release by ryanodine receptors (RyRs) due to intracellular calcium overload results in delayed afterdepolarisations, closely associated with life-threatening arrhythmias. In this regard, inhibiting lysosomal calcium release by two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39030d8c98485ccaec44f65d5d9c256f
https://doi.org/10.1101/2022.11.09.515777
https://doi.org/10.1101/2022.11.09.515777
Autor:
Peter M. Haggie, Jae Seok Yoon, Mathias Schenkel, Samuel J. Bose, William R. Skach, David N. Sheppard, Michael Schlierf, Demi R S Ng, Georg Krainer, Hideki Shishido
Publikováno v:
Journal of Cystic Fibrosis
Highlights • Co-translational folding of NBD1 is disrupted by CF mutations. • FRET analysis of transmembrane constructs reveals misfolding by CF mutations. • The impact of the F508del mutation on CFTR is species-dependent. • Two potentiators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869edb2a0252eb0fd4d99bcb11e3e682
http://europepmc.org/articles/PMC7052731
http://europepmc.org/articles/PMC7052731
Autor:
Samuel J. Bose, Matthew Read, Rebecca A Capel, Emily Akerman, Thamali Ayagama, Angela Russell, Derek A Terrar, Manuela Zaccolo, Rebecca AB Burton
Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial specific target for AF therapy, and atrial IP3 signalling has been linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dda20271c99a120765268389f79bcaa
https://doi.org/10.1101/2022.01.06.475211
https://doi.org/10.1101/2022.01.06.475211
Autor:
Luiz G.N. de Almeida, Ulrich auf dem Keller, Thamali Ayagama, Uilla Barcick, Samuel J. Bose, Louise Bundgaard, Rebecca A.B. Burton, Daniela Cajado-Carvalho, Maurício Frota Camacho, Niels Olsen Saraiva Câmara, Camila Rolemberg Santana Travaglini Berti de Correia, Patrícia Maria Siqueira dos Passos, Antoine Dufour, Wolfgang Esser-Skala, Jessica de Alcantara Ferreira, Nikolaus Fortelny, Vanessa Morais Freitas, Daniela C. Granato, Hinrich P. Hansen, Tâmisa Seeko Bandeira Honda, Pitter F. Huesgen, Ruy Gastaldoni Jaeger, Konstantinos Kalogeropoulos, Maithreyan Kuppusamy, Andrei Leitão, Adriana F. Paes Leme, João Agostinho Machado-Neto, Isabela Fernanda Morales Martins, Milene Cristina Menezes, Leandro X. Neves, Caio Almeida Batista de Oliveira, Barbara Nunes Padovani, Murilo Salardani, Adriane Sousa de Siqueira, Valentine Spagnol, Felipe Roberti Teixeira, Dilza Trevisan-Silva, Luciana D. Trino, André Zelanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88de102292cfe3bc0830f0145afb68b9
https://doi.org/10.1016/b978-0-323-85696-6.09991-1
https://doi.org/10.1016/b978-0-323-85696-6.09991-1