Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Samuel J Barnes"'
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic regulation is essential for stable neuronal function. Several synaptic mechanisms of homeostatic plasticity have been described, but the functional properties of synapses involved in homeostasis are unknown. We used longitudinal two-photo
Externí odkaz:
https://doaj.org/article/1d5f71042f194154bd2a9221144e2f0f
Autor:
Thomas Knöpfel, Yann Sweeney, Carola I. Radulescu, Nawal Zabouri, Nazanin Doostdar, Claudia Clopath, Samuel J. Barnes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Sensory stimuli usually arrive simultaneously but the neural-circuit mechanisms that combine multiple streams of sensory information are incompletely understood. The authors here show that visual-auditory pairing drives plasticity in multi-modal neur
Externí odkaz:
https://doaj.org/article/b59fcdd02a4047f1b6117f7a8958b6d5
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 576-584 (2018)
Persistent synapses are thought to underpin the storage of sensory experience, yet little is known about their structural plasticity in vivo. We investigated how persistent presynaptic structures respond to the loss of primary sensory input. Using in
Externí odkaz:
https://doaj.org/article/bab4710f799a4876874d2d406d35123a
Autor:
Abbas, Dehghan, Rui Climaco, Pinto, Ibrahim, Karaman, Jian, Huang, Brenan R, Durainayagam, Mohsen, Ghanbari, Areesha, Nazeer, Qi, Zhong, Sonia, Liggi, Luke, Whiley, Rima, Mustafa, Miia, Kivipelto, Alina, Solomon, Tiia, Ngandu, Takahisa, Kanekiyo, Tomonori, Aikawa, Carola I, Radulescu, Samuel J, Barnes, Gonçalo, Graça, Elena, Chekmeneva, Stephane, Camuzeaux, Matthew R, Lewis, Manuja R, Kaluarachchi, M Arfan, Ikram, Elaine, Holmes, Ioanna, Tzoulaki, Paul M, Matthews, Julian L, Griffin, Paul, Elliott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44758504b5724d9b2d5c5ea4c29cba19
https://pubmed.ncbi.nlm.nih.gov/36269859
https://pubmed.ncbi.nlm.nih.gov/36269859
Autor:
Michael J. Morten, Liina Sirvio, Huzefa Rupawala, Emma Mee Hayes, Aitor Franco, Carola Radulescu, Liming Ying, Samuel J. Barnes, Arturo Muga, Yu Ye
Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data suggest that smaller aggregates cause higher toxic response than filamentous aggregates (fibrils). However, the size of small aggregates has challenged their dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca2ffcea7d7251652f565092d2ac05d
http://hdl.handle.net/10044/1/100274
http://hdl.handle.net/10044/1/100274
Autor:
Abbas Dehghan, Rui Climaco Pinto, Ibrahim Karaman, Jian Huang, Brenan R. Durainayagam, Mohsen Ghanbari, Areesha Nazeer, Qi Zhong, Sonia Liggi, Luke Whiley, Rima Mustafa, Miia Kivipelto, Alina Solomon, Tiia Ngandu, Takahisa Kanekiyo, Tomonori Aikawa, Carola I. Radulescu, Samuel J. Barnes, Gonçalo Graça, Elena Chekmeneva, Stephane Camuzeaux, Matthew R. Lewis, Manuja R. Kaluarachchi, M. Arfan Ikram, Elaine Holmes, Ioanna Tzoulaki, Paul M. Matthews, Julian L. Griffin, Paul Elliott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(43):e2206083119. National Academy of Sciences
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer’s disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673c19cb621adb590cf6d6076a05edd5
http://hdl.handle.net/10044/1/100823
http://hdl.handle.net/10044/1/100823
Autor:
Samuel J. Barnes, Larissa Stead, Emily Palmer, Bibiana C. Mota, Nicola Davis, Laura Lombardero, Rafael Rodríguez-Puertas, Magdalena Sastre, Vincenzo De Paola
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-12 (2021)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Universidad de Cantabria (UC)
Journal of Neuroinflammation
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Universidad de Cantabria (UC)
Journal of Neuroinflammation
Background Astrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer’s disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4964a8d4316fa08f8a5167ac58b3dd1
https://doaj.org/article/1987dcf4e1594d9b924e641c98dbaefd
https://doaj.org/article/1987dcf4e1594d9b924e641c98dbaefd
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Manuel C. Marzin, Stergios Tsartsalis, Robert C.J. Muirhead, Irene Falk, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katie Wiltshire, Paula Beltran-Lobo, Alexandra Philips, Jack Antel, Luke Healy, Craig S. Moore, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Paul M. Matthews, Sandra Amor, David R. Owen
Microglial activation plays central roles in neuro-inflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8719241c8e97acc9b023c673aa4e81fa
https://doi.org/10.1101/2022.05.11.491453
https://doi.org/10.1101/2022.05.11.491453
Autor:
Samuel J. Barnes, Carola I. Radulescu
Publikováno v:
Current Biology. 31:R721-R723
Summary A new study explores the neural-circuit and synaptic processes that support the transition from general to specific aversive memory formation. A critical role for homeostatic synaptic down-scaling in shaping the specificity of an associative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb9c9abe60fece7e8febafbdec92499
https://doi.org/10.1016/j.cub.2021.04.023
https://doi.org/10.1016/j.cub.2021.04.023