Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory Stimuli

Autor: Priscilla E. Day-Walsh, Bryony Keeble, Gothai Pirabagar, Samuel J. Fountain, Paul A. Kroon

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8646 (2022)

Junctional adhesion molecules (JAMs; comprising JAM-A, -B and -C) act as receptors for viruses, mediate cell permeability, facilitate leukocyte migration during sterile and non-sterile inflammation and are important for the maintenance of epithelial

Externí odkaz: https://doaj.org/article/1e09f33516f340c0b38a055e5599abc2

STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes

Autor: Yasser Majeed, Aisha Y. Madani, Ahmed I. Altamimi, Raphael Courjaret, Muneera Vakayil, Samuel J. Fountain, Khaled Machaca, Nayef A. Mazloum

Background and Purpose: Senescent preadipocytes promote adipose tissue dysfunction by secreting pro-inflammatory factors, although little is known about the mechanisms regulating their production. We investigated if up-regulated purinoceptor function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4542158a99f1e9a4bbda34798c3ebb
https://ueaeprints.uea.ac.uk/id/eprint/89083/

Contributors

Autor: Daniela Accorsi–Mendonça, David J. Adams, Andrew M. Allen, Marlies Alvarenga, Jeffrey L. Ardell, Amy C. Arnold, Jesse L. Ashton, Mark B. Badrov, Brennan A. Ballantyne, Emma N. Bardsley, Soledad Barez-Lopez, Susan M. Barman, Carolyn J. Barrett, Deborah Bauer, Christopher Bell, Alona Ben-Tal, Eduardo E. Benarroch, Italo Biaggioni, Katharina Brandl, Virginia L. Brooks, Amy E. Brown, Kirsteen N. Browning, Meredith Bryarly, Livia L. Camargo, Michael Camilleri, Preston J. Campbell, Marc G. Caron, Jason R. Carter, Mark W. Chapleau, Nisha Charkoudian, Gisela Chelimsky, Thomas C. Chelimsky, Pitcha Chompoopong, Victoria E. Claydon, Gilles Clément, Victor A. Convertino, Elizabeth A. Coon, Pietro Cortelli, Stephen N. Davis, André Diedrich, Donald J. DiPette, Debra I. Diz, Marcus J. Drake, Graeme Eisenhofer, Florent Elefteriou, Fernando Elijovich, Eva-Maria Elmenhorst, Brett A. English, Murray Esler, Rosemary Esler, Paul J. Fadel, John M. Fahrenholz, Alessandra Fanciulli, John Y. Fang, Robert D. Fealey, Nathanne S. Ferreira, Renato Filogonio, Gregory D. Fink, James P. Fisher, John S. Floras, Samuel J. Fountain, Qi Fu, Marat Fudim, Raffaello Furlan, Alfredo Gamboa, Emily M. Garland, Christopher H. Gibbons, Andrew Giritharan, David S. Goldstein, Diego A. Golombék, Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez, Robert M. Graham, Guido Grassi, Ian M. Greenlund, Blair P. Grubb, Alla Guekht, Sarah-Jane Guild, Ling Guo, Vsevolod V. Gurevich, Ralf Habermann, Joseph Hadaya, Maureen K. Hahn, Peter Hanna, Luke A. Henderson, Neil Herring, Max J. Hilz, Peter Hunter, Keith Hyland, Lauren A. Hyland, Edwin Kerry Jackson, Giris Jacob, Wilfrid Jänig, Nina Japundžić-Žigon, Carrie K. Jones, Karen M. Joos, Jens Jordan, William Joyce, Xenia Kaidonis, Horacio Kaufmann, David Kaye, Abdul Mannan Khan Minhas, Joyce S. Kim, Takeya Kitta, David D. Kline, Thomas Konecny, Natalie J. Koons, Ambrish Kumar, Cheryl L. Laffer, Andre H. Lagrange, Nora Laiken, Gavin Lambert, Elisabeth Lambert, Guillaume Lamotte, Jacques W.M. Lenders, Benjamin D. Levine, Fabian Leys, Ulrich Limper, Mabelle Lin, Eduardo Listik, Reid Longmuir, David A. Low, Phillip A. Low, James M. Luther, Vaughan G. Macefield, Benedito H. Machado, Maria-Bernadette Madel, Davide Martelli, Christopher J. Mathias, Michelle L. Mauermann, Robin M. McAllen, Fiona D. McBryde, Andrew McKeon, Michael J. McKinley, Clément Menuet, Douglas F. Milam, Marion C. Mohl, Johanna M. Montgomery, Davi J.A. Moraes, Shaun F. Morrison, David Murphy, Charles D. Nichols, Piotr Niewiński, Lucy Norcliffe-Kaufmann, Luis E. Okamoto, Mahyar Osanlouy, John W. Osborn, Viktor Oubaid, Jose-Alberto Palma, Christina Pamporaki, Brian A. Parsons, David J. Paterson, Julian F.R. Paton, Amanda C. Peltier, Umberto Pensato, Sean M. Peterson, Fenna T. Phibbs, Giulia Pierangeli, Jay D. Potts, Alejandro A. Rabinstein, Mohan K. Raizada, Satish R. Raj, Casey M. Rand, Heinz Reichmann, Calum Robertson, Rose Marie Robertson, Michael B. Robinson, Mohammed Ruzieh, Paola Sandroni, Takayuki Sato, Ernesto L. Schiffrin, Markus Schlaich, Ronald Schondorf, Harold D. Schultz, Michael M. Scott, Gino Seravalle, John R. Shannon, Abu Baker Sheikh, Cyndya A. Shibao, Kalyanam Shivkumar, Kamal Shouman, Timo Siepmann, Wolfgang Singer, Elias Soltani, Virend Somers, Aadhavi Sridharan, Nadia Stefanova, Julian Stewart, Lauren E. Stiles, Kenji Sunagawa, Jens Tank, Roland D. Thijs, Jakub Tomek, Rhian M. Touyz, Jennifer A. Tracy, R. Alberto Travagli, Bradley J. Undem, Nikhil Urs, Steven Vernino, Lauro C. Vianna, Daniel E. Vigo, Margaret A. Vizzard, Amr Wahba, Waqar Waheed, Han-Jun Wang, Tobias Wang, Qin Wang, Ruihao Wang, Debra E. Weese-Mayer, Gregor K. Wenning, Wouter Wieling, Kevin W. Williams, Ursula H. Winzer-Serhan, Scott Wood, Kai Lee Yap, Naoki Yoshimura, Kirill A. Zavalin, Dmitry Zhuravlev, Daniel B. Zoccal, Jasenka Zubcevic

Publikováno v: Primer on the Autonomic Nervous System ISBN: 9780323854924

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bafd1601fa1262b19bc5727a98b1d87
https://doi.org/10.1016/b978-0-323-85492-4.01002-4

Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition

Autor: Seema Ali, Izzuddin Bin Nadzirin, Neville Ngum, David Richards, Anna Fortuny-Gomez, Samuel J. Fountain, Mark Searcey

Publikováno v: British Journal of Pharmacology. 178:4859-4872

Background & purpose P2X4 is a ligand-gated cation channel activated by extracellular ATP, involved in neuropathic pain, inflammation and arterial tone. Experimental approach Natural products were screened against human or mouse P2X4 activity using f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa5bf637109115b87cf3b0c20c6f215
https://doi.org/10.1111/bph.15663

ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation

Autor: Janice A. Layhadi, Samuel J. Fountain

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 20, p 5113 (2019)

Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to macrophage with differing functional phenotypes. Here, we investigate

Externí odkaz: https://doaj.org/article/e5d90f2d4a0244dcb8942ab1be513aef