Zobrazeno 1 - 10
of 1 099
pro vyhledávání: '"Samuel J, Danishefsky"'
Autor:
Kevin O. Saunders, Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R. Ryan Meyerhoff, Robert Parks, William E. Walkowicz, Baptiste Aussedat, Nelson R. Wu, Fangping Cai, Yusuf Vohra, Peter K. Park, Amanda Eaton, Eden P. Go, Laura L. Sutherland, Richard M. Scearce, Dan H. Barouch, Ruijun Zhang, Tarra Von Holle, R. Glenn Overman, Kara Anasti, Rogier W. Sanders, M. Anthony Moody, Thomas B. Kepler, Bette Korber, Heather Desaire, Sampa Santra, Norman L. Letvin, Gary J. Nabel, David C. Montefiori, Georgia D. Tomaras, Hua-Xin Liao, S. Munir Alam, Samuel J. Danishefsky, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://doaj.org/article/f020d40e9877461f93e8d9d15c7fa9e4
Autor:
Chelcie H. Eller, Tzu-Yuan Chao, Kiran K. Singarapu, Ouathek Ouerfelli, Guangbin Yang, John L. Markley, Samuel J. Danishefsky, Ronald T. Raines
Publikováno v:
ACS Central Science, Vol 1, Iss 4, Pp 181-190 (2015)
Externí odkaz:
https://doaj.org/article/1105c7e6464745a6b61e86682671d8b0
Autor:
Samuel J. Danishefsky
Publikováno v:
The Journal of Antibiotics. 72:319-322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ffd67f70203ec9223769b570b493534
https://doi.org/10.1038/s41429-019-0179-7
https://doi.org/10.1038/s41429-019-0179-7
Autor:
John A. Brailsford, Jennifer L. Stockdill, Eric V. Johnston, Abram J. Axelrod, Paul A. Vadola, Samuel J. Danishefsky, Michael T. Peterson
Publikováno v:
Tetrahedron. 74:1951-1956
The β-subunit of human thyroid stimulating hormone (hTSH) has been synthesized as a single glycoform bearing a chitobiose disaccharide at the native glycosylation site. Key to the successful completion of this synthesis was the introduction of an ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8922168370d39e468501e1414bb3bb
https://doi.org/10.1016/j.tet.2018.02.067
https://doi.org/10.1016/j.tet.2018.02.067
Autor:
William E. Walkowicz, Samuel J. Danishefsky, Barton F. Haynes, Baptiste Aussedat, Mattia Bonsignori, Daniela Fera, Jeffrey O. Zhou, Stephen C. Harrison, Alessandro Piai, Matthew S. Lee, R. Ryan Meyerhoff, Kevin Wiehe, Therese Ton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591802380d054e8a134dc37e8b49f997
https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
Autor:
Robert Parks, Nelson R. Wu, Thomas B. Kepler, Fangping Cai, Tarra Von Holle, Yusuf Vohra, Bette T. Korber, Georgia D. Tomaras, Mattia Bonsignori, Barton F. Haynes, Samuel J. Danishefsky, M. Anthony Moody, Richard M. Scearce, Amanda Eaton, Eden P. Go, Ruijun Zhang, Hua-Xin Liao, Peter K. Park, Sampa Santra, Dan H. Barouch, Nathan I. Nicely, Heather Desaire, Kevin O. Saunders, R. Ryan Meyerhoff, David C. Montefiori, William E. Walkowicz, Kevin Wiehe, Rogier W. Sanders, Kara Anasti, Gary J. Nabel, R. Glenn Overman, Baptiste Aussedat, S. Munir Alam, Norman L. Letvin, Laura L. Sutherland
Publikováno v:
Cell reports, 18(9), 2175-2188. Cell Press
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb437a4f63864a9bba94b8e3b3f33f26
https://doi.org/10.1016/j.celrep.2017.02.003
https://doi.org/10.1016/j.celrep.2017.02.003
Recent advances have demonstrated the feasibility and robustness of chemical synthesis for the production of homogeneously glycosylated protein forms (glycoforms). By taking advantage of the unmatchable flexibility and precision provided by chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aa9b2c190d3ece7d9ba07eb8ec6ad2
https://doi.org/10.1016/bs.mie.2019.02.030
https://doi.org/10.1016/bs.mie.2019.02.030
Autor:
Guangbin Yang, Samuel J. Danishefsky, Ouathek Ouerfelli, Chelcie H. Eller, Tzu-Yuan Chao, John L. Markley, Ronald T. Raines, Kiran Kumar Singarapu
Publikováno v:
ACS Central Science
ACS Central Science, Vol 1, Iss 4, Pp 181-190 (2015)
ACS Central Science, Vol 1, Iss 4, Pp 181-190 (2015)
Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells, leading to a clinical trial. The basis for the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716850caef6736ea114f8d8a54b5fd33
http://europepmc.org/articles/PMC4571170
http://europepmc.org/articles/PMC4571170
Publikováno v:
Accounts of Chemical Research. 48:643-652
The development of anticancer vaccines requires the identification of unique epitope markers, preferably expressed exclusively on the surface of cancer cells. This Account describes the path of development of a carbohydrate-based vaccine for metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506afe1c61ceda532dd250633e67b8b4
https://doi.org/10.1021/ar5004187
https://doi.org/10.1021/ar5004187