Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel Itskanov"'
Autor:
Kevin Wu, Samuel Itskanov, Diane L. Lynch, Yuanyuan Chen, Aasha Turner, James C. Gumbart, Eunyong Park
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins. Although Doa10 is highly conserved across
Externí odkaz:
https://doaj.org/article/be2e86f1e3154106b7a2c1e7f41a8492
Autor:
Samuel Itskanov, Laurie Wang, Tina Junne, Rumi Sherriff, Li Xiao, Nicolas Blanchard, Wei Q. Shi, Craig Forsyth, Dominic Hoepfner, Martin Spiess, Eunyong Park
Publikováno v:
Nature Chemical Biology.
The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum (ER) membrane that is required for secretion of soluble proteins and production of many membrane proteins. Several natural and synthetic small molecules specifically in
Autor:
Samuel Itskanov, Eunyong Park
Publikováno v:
Cold Spring Harbor perspectives in biology.
The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation in eukaryotic cells, responsible for production of secretory proteins and most integral membrane proteins. The universally conserved protein-conducting chan
Publikováno v:
Nature structural & molecular biology
Nature structural & molecular biology, vol 28, iss 2
Nature structural & molecular biology, vol 28, iss 2
Many proteins are transported into the endoplasmic reticulum by the universally conserved Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and Sec63, but their functions are poorly defined. In the present study, we
Autor:
Eunyong Park, Samuel Itskanov
SummaryThe universally conserved Sec61/SecY channel mediates transport of many newly synthesized polypeptides across membranes, an essential step in protein secretion and membrane protein integration1-5. The channel has two gating mechanisms—a lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b015b2d570434cb00d91e642d5ce76f8
https://doi.org/10.1101/2020.12.14.422728
https://doi.org/10.1101/2020.12.14.422728
Autor:
Jan B. Parys, David Schlütermann, Hendrik Niemann, Stefanie Weidtkamp-Peters, Samuel Itskanov, Ana J. García-Sáez, Elisabeth Wesbuer, Niklas Berleth, Marian Frank, Andrea Borchardt, Björn Stork, Peter Proksch, Andreas Barbian, Tomas Luyten, Jana Deitersen, Arun Kumar Kondadi, Philip Böhler, Nora Wallot-Hieke, Alexander M. van der Bliek, Sebastian Wesselborg, Fabian Stuhldreier, Wenxian Wu, Ruchika Anand, Andreas S. Reichert, Aida Peña-Blanco
Publikováno v:
Cell Death and Disease, Vol 9, Iss 3, Pp 1-17 (2018)
Cell Death & Disease
Cell death & disease, vol 9, iss 3
Cell Death & Disease
Cell death & disease, vol 9, iss 3
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial toxins, man
Autor:
Eunyong Park, Samuel Itskanov
Publikováno v:
Science (New York, N.Y.), vol 363, iss 6422
The Sec61 protein-conducting channel mediates transport of many proteins, such as secretory proteins, across the endoplasmic reticulum (ER) membrane during or after translation. Posttranslational transport is enabled by two additional membrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e238ea5ee599f3ab58e72a5f4b6296e
https://escholarship.org/uc/item/8xt8z7rd
https://escholarship.org/uc/item/8xt8z7rd
Publikováno v:
Biophysical Journal. 114:200a