Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Samuel I. Miller"'
Autor:
Alexander Eng, Hillary S. Hayden, Christopher E. Pope, Mitchell J. Brittnacher, Anh T. Vo, Eli J. Weiss, Kyle R. Hager, Daniel H. Leung, Sonya L. Heltshe, Daniel Raftery, Samuel I. Miller, Lucas R. Hoffman, Elhanan Borenstein
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Infants with cystic fibrosis (CF) suffer from gastrointestinal (GI) complications, including pancreatic insufficiency and intestinal inflammation, which have been associated with impaired nutrition and growth. Recent evidence iden
Externí odkaz:
https://doaj.org/article/69900369972c4aafab8be30c1ed91e63
Autor:
Daniel Mann, Junping Fan, Kamolrat Somboon, Daniel P. Farrell, Andrew Muenks, Svetomir B. Tzokov, Frank DiMaio, Syma Khalid, Samuel I. Miller, Julien R. C. Bergeron
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Daniel Mann et al. describe a higher-resolution structure of the maintenance of lipid asymmetry inner membrane complex (MlaBDEF) in the Gram-negative pathogen, Acinetobacter baumannii. With this improved structural map, the authors clarify the second
Externí odkaz:
https://doaj.org/article/85d066ee80af486582adf7e304e0d791
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrob
Externí odkaz:
https://doaj.org/article/37bede7359424917bc4367ca879c6ab8
Autor:
Anna M. Kolodziejek, Melissa A. Altura, Junping Fan, Erik M. Petersen, Matthew Cook, Peter S. Brzovic, Samuel I. Miller
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2147-2156.e5 (2019)
Summary: Intracellular Salmonella use a type III secretion system (TTSS) to translocate effector proteins across the phagosome membrane and thus promote vacuole membrane tubulation, resulting in intracellular survival. This work demonstrates that the
Externí odkaz:
https://doaj.org/article/b601ce380b8f420ea55a922f7f2a0a92
Autor:
Maria T. Nelson, Christopher E. Pope, Robyn L. Marsh, Daniel J. Wolter, Eli J. Weiss, Kyle R. Hager, Anh T. Vo, Mitchell J. Brittnacher, Matthew C. Radey, Hillary S. Hayden, Alexander Eng, Samuel I. Miller, Elhanan Borenstein, Lucas R. Hoffman
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2227-2240.e5 (2019)
Summary: Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses a
Externí odkaz:
https://doaj.org/article/aa353231eef24d6ba4bb9100acd19923
Autor:
Xia Wu, Juan D. Chavez, Devin K. Schweppe, Chunxiang Zheng, Chad R. Weisbrod, Jimmy K. Eng, Ananya Murali, Samuel A. Lee, Elizabeth Ramage, Larry A. Gallagher, Hemantha D. Kulasekara, Mauna E. Edrozo, Cassandra N. Kamischke, Mitchell J. Brittnacher, Samuel I. Miller, Pradeep K. Singh, Colin Manoil, James E. Bruce
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of
Externí odkaz:
https://doaj.org/article/1333b90e086549de845305809266c010
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however
Externí odkaz:
https://doaj.org/article/516ede72380646ce9c2c77b8595f212e
Autor:
Samuel I. Miller
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The Gram-negative outer membrane is an important barrier that provides protection against toxic compounds, which include antibiotics and host innate immune molecules such as cationic antimicrobial peptides. Recently, significant research pro
Externí odkaz:
https://doaj.org/article/d928679486c64fb081e707a4acda07d9
Autor:
Hillary S. Hayden, Susana Matamouros, Kyle R. Hager, Mitchell J. Brittnacher, Laurence Rohmer, Matthew C. Radey, Eli J. Weiss, Katie B. Kim, Michael A. Jacobs, Elizabeth H. Sims-Day, Min Yue, Mussaret B. Zaidi, Dieter M. Schifferli, Shannon D. Manning, Judd L. Walson, Samuel I. Miller
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading t
Externí odkaz:
https://doaj.org/article/db54af932ed441378875a50e1fe8f57f
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstrea
Externí odkaz:
https://doaj.org/article/9667a86201c048a4a331292c9434ce9c