Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Samuel I. Mattern-Schain"'
Autor:
Richard K. Fisher, Phillip C. West, Samuel I. Mattern-Schain, Michael D. Best, Stacy S. Kirkpatrick, Raymond A. Dieter, Joshua D. Arnold, Michael R. Buckley, Michael M. McNally, Michael B. Freeman, Oscar H. Grandas, Deidra J. H. Mountain
Publikováno v:
Nanomaterials, Vol 11, Iss 3, p 825 (2021)
Lipid nanoparticles have become increasingly popular delivery platforms in the field of gene therapy, but bench-to-bedside success has been limited. Many liposomal gene vectors are comprised of synthetic cationic lipids, which are associated with lip
Externí odkaz:
https://doaj.org/article/417343aefefb4e48ab74582144011023
Autor:
Megan L. Qualls, Hannah Hagewood, Jinchao Lou, Samuel I. Mattern‐Schain, Xiaoyu Zhang, Deidra J. Mountain, Michael D. Best
Publikováno v:
ChemBioChem. 23
Liposomes are effective therapeutic nanocarriers due to their ability to encapsulate and enhance the pharmacokinetic properties of a wide range of drugs and diagnostic agents. A primary area in which improvement is needed for liposomal drug delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79271bc4b57a942a580c16fed9af3571
https://doi.org/10.1002/cbic.202200402
https://doi.org/10.1002/cbic.202200402
Autor:
Samuel I. Mattern-Schain, Michael D. Best, Taylor M. Harris, Oscar H. Grandas, Richard K. Fisher, Lauren B. Grimsley, Deidra J.H. Mountain, Philip C. West
Publikováno v:
Chemistry and Physics of Lipids. 218:149-157
Liposomal delivery systems (LDSs) have been at the forefront of medicinal nanotechnology for over three decades. Increasing LDS association to target cells and cargo delivery is crucial to bolstering overall nanodrug efficacy. Our laboratory aims to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9d18d67d725f2803886b9b1912a9b9
https://doi.org/10.1016/j.chemphyslip.2018.12.009
https://doi.org/10.1016/j.chemphyslip.2018.12.009
Autor:
Deidra J.H. Mountain, Phillip C. West, Joshua D. Arnold, Michael R. Buckley, Samuel I. Mattern-Schain, Michael M. McNally, Stacy S. Kirkpatrick, Oscar H. Grandas, Raymond A. Dieter, Michael D. Best, Richard K. Fisher, Michael B. Freeman
Publikováno v:
Nanomaterials
Volume 11
Issue 3
Nanomaterials, Vol 11, Iss 825, p 825 (2021)
Volume 11
Issue 3
Nanomaterials, Vol 11, Iss 825, p 825 (2021)
Lipid nanoparticles have become increasingly popular delivery platforms in the field of gene therapy, but bench-to-bedside success has been limited. Many liposomal gene vectors are comprised of synthetic cationic lipids, which are associated with lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7965c973f78af3ee57c7117fb51b0221
https://pubmed.ncbi.nlm.nih.gov/33807086
https://pubmed.ncbi.nlm.nih.gov/33807086
Publikováno v:
Chemistry - A European Journal. 24:3599-3607
Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium-a target chosen due to its key roles in biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823011940d191b12f2e764569ea16f8f
https://doi.org/10.1002/chem.201705810
https://doi.org/10.1002/chem.201705810
Autor:
James Manuel, Donald J. Leo, Eric C. Freeman, Joshua J. Maraj, Scott C. Lenaghan, Tayler M. Schimel, Stephen A. Sarles, Mary-Anne Nguyen, Samuel I. Mattern-Schain
Publikováno v:
ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems.
This work draws inspiration from totipotent cellular systems to design smart materials whose compositions and properties can be learned or evolved. Totipotency refers to the inherent genetic potential of a single cell to adapt and produce all types o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0027ae76530bc7930069e17c6d6b01b2
https://doi.org/10.1115/smasis2019-5745
https://doi.org/10.1115/smasis2019-5745
Autor:
Richard K. Fisher, Samuel I. Mattern-Schain, Lauren B. Grimsley, Deidra J.H. Mountain, Michael D. Best, Oscar H. Grandas, Stacy S. Kirkpatrick
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Introduction: Our laboratory aims to develop biocompatible nanocarriers for molecular therapeutics aimed at vascular pathology. We have previously established a liposome platform that is an effective delivery system for RNAi in vascular smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd0e4316d8c3011054014ad57146167
https://doi.org/10.1161/atvb.38.suppl_1.273
https://doi.org/10.1161/atvb.38.suppl_1.273
Autor:
Adam J. Carr, Samuel I. Mattern-Schain, Stuart A. Whitehead, Vladimir V. Popik, Shahrina Alam, Christopher D. McNitt, Michael D. Best
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion, oxo-dibenzocyclooctyne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00254aeadfa7fcef77e59b145ff07ea
https://europepmc.org/articles/PMC5990007/
https://europepmc.org/articles/PMC5990007/
Autor:
Michael B. Freeman, Richard K. Fisher, Stacy S. Kirkpatrick, Michael D. Best, Oscar H. Grandas, Samuel I. Mattern-Schain, Deidra J.H. Mountain
Publikováno v:
The Journal of surgical research. 219
Background We have previously defined mechanisms of intimal hyperplasia that could be targets for molecular therapeutics aimed at vascular pathology. However, biocompatible nanocarriers are needed for effective delivery. Cationic liposomes (CLPs) hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62841e3403d1cd00d8e825f976d89b0
https://pubmed.ncbi.nlm.nih.gov/29078873
https://pubmed.ncbi.nlm.nih.gov/29078873
Lipid-based supramolecular assemblies have found widespread use as molecular cargo containers in biomedical delivery applications. This is due to the ability of self-assembled lipid systems such as liposomes to encapsulate molecules with a range of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4685a2487d700f6c8f25cd97722daed
https://doi.org/10.1016/b978-0-12-409547-2.12540-5
https://doi.org/10.1016/b978-0-12-409547-2.12540-5