Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Samuel I. Gunderson"'
Autor:
Darren R. Carpizo, Samuel I. Gunderson, Eric S. Ho, Mark A. Brenneman, Samuel Kogan, Kristen Donohue, Rafal Goraczniak, Xin Yu, Lan Yi, Crissy Dudgeon, Ashley T. Tsang
Supplemental Figures 1-4 with figure legends and Supplemental Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bf9136fc16c0f2a96916f81faad83f
https://doi.org/10.1158/1535-7163.22508458
https://doi.org/10.1158/1535-7163.22508458
Autor:
Wencheng Li, Bei You, Mainul Hoque, Dinghai Zheng, Wenting Luo, Zhe Ji, Ji Yeon Park, Samuel I Gunderson, Auinash Kalsotra, James L Manley, Bin Tian
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005166 (2015)
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3' untranslated regions (3'UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA kn
Externí odkaz:
https://doaj.org/article/1a400975ac4d468698a88a3973e03927
Autor:
Wenting Luo, Zhe Ji, Zhenhua Pan, Bei You, Mainul Hoque, Wencheng Li, Samuel I Gunderson, Bin Tian
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003613 (2013)
The human gene encoding the cleavage/polyadenylation (C/P) factor CstF-77 contains 21 exons. However, intron 3 (In3) accounts for nearly half of the gene region, and contains a C/P site (pA) with medium strength, leading to short mRNA isoforms with n
Externí odkaz:
https://doaj.org/article/93f4bac936cf4e118d68da74423e3a9f
Autor:
Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie LaCava, Kenneth R Reuhl, Suzie Chen, Samuel I Gunderson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
U1 Adaptor is a recently discovered oligonucleotide-based gene-silencing technology with a unique mechanism of action that targets nuclear pre-mRNA processing. U1 Adaptors have two distinct functional domains, both of which must be present on the sam
Externí odkaz:
https://doaj.org/article/05875fbc03754cd9bb797287478d6134
Autor:
Eric S. Ho, Mark Brenneman, Crissy Dudgeon, Rafal Goraczniak, Lan Yi, Xin Yu, Samuel I. Gunderson, Ashley T. Tsang, Kristen Donohue, Darren R. Carpizo, Samuel Kogan
Publikováno v:
Molecular Cancer Therapeutics. 16:1445-1455
Targeting KRAS and MYC has been a tremendous challenge in cancer drug development. Genetic studies in mouse models have validated the efficacy of silencing expression of both KRAS and MYC in mutant KRAS-driven tumors. We investigated the therapeutic
Autor:
Ashley T, Tsang, Crissy, Dudgeon, Lan, Yi, Xin, Yu, Rafal, Goraczniak, Kristen, Donohue, Samuel, Kogan, Mark A, Brenneman, Eric S, Ho, Samuel I, Gunderson, Darren R, Carpizo
Publikováno v:
Molecular cancer therapeutics. 16(8)
Targeting KRAS and MYC has been a tremendous challenge in cancer drug development. Genetic studies in mouse models have validated the efficacy of silencing expression of both KRAS and MYC in mutant KRAS driven tumors. We investigated the therapeutic
Autor:
Anna Rabkin, Marina Chekmareva, Samuel I. Gunderson, Suzie Chen, David J. Foran, Wenjin Chen, Rajeev K. Boregowda, Michael A. Bryan, Ahmed Lasfar, Daniel J. Medina, James S. Goydos, Karine A. Cohen-Solal, Michael J. Vido, Elke Markert
Publikováno v:
Oncotarget
Receptor tyrosine kinases-based autocrine loops largely contribute to activate the MAPK and PI3K/AKT pathways in melanoma. However, the molecular mechanisms involved in generating these autocrine loops are still largely unknown. In the present study,
Autor:
Samuel I. Gunderson, Eric S. Ho
Publikováno v:
Genome Biology and Evolution
Polyadenylation is a cotranscriptional nuclear RNA processing event involving endonucleolytic cleavage of the nascent, emerging pre-messenger RNA (pre-mRNA) from the RNA polymerase, immediately followed by the polymerization of adenine ribonucleotide
Autor:
Lauren Alpert, William G. Fairbrother, Brian L. Chang, William Thompson, Samuel I. Gunderson, Daniel C. Reid
Publikováno v:
RNA. 15:2385-2397
Many splicing factors interact with both mRNA and pre-mRNA. The identification of these interactions has been greatly improved by the development of in vivo cross-linking immunoprecipitation. However, the output carries a strong sampling bias in favo
Publikováno v:
Nature Biotechnology. 27:257-263
We describe a gene silencing method that employs a mechanism of action distinct from those of antisense and RNA interference. U1 Adaptors are bifunctional oligonucleotides with a 'target domain' complementary to a site in the target gene's terminal e