Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samuel I. Blum"'
Autor:
Samuel I. Blum, Jared P. Taylor, Jessie M. Barra, Ashley R. Burg, Qiao Shang, Shihong Qiu, Oren Shechter, Aleah R. Hayes, Todd J. Green, Aron M. Geurts, Yi-Guang Chen, Hubert M. Tse
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic β cell destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated protein 5–dependent (MDA5-dependent) antiviral responses are linked with T1D deve
Externí odkaz:
https://doaj.org/article/481ea67a6fde4ec79a6074eb8b6ff38c
Autor:
Samuel I. Blum, Hubert M. Tse
Publikováno v:
Microorganisms, Vol 8, Iss 7, p 993 (2020)
Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-mediated destruction of insulin-producing β-cells. The concordance rate for T1D in monozygotic twins is ≈30–50%, indicating that environmental factors also play a ro
Externí odkaz:
https://doaj.org/article/f7f044da59ca488aa2cd5619ad899407
Autor:
Samuel I. Blum, Jared P. Taylor, Jessie M. Barra, Ashley R. Burg, Qiao Shang, Shihong Qiu, Oren Shechter, Aleah R. Hayes, Todd J. Green, Aron M. Geurts, Yi-Guang Chen, Hubert M. Tse
Publikováno v:
JCI insight.
Type 1 diabetes (T1D) is an autoimmune disease resulting in pancreatic β-cell destruction. Coxsackievirus B3 (CVB3) infection and melanoma differentiation-associated protein 5 (MDA5)-dependent antiviral responses are linked with T1D development. Mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e07066f535c033fc6fabe2c4aa5be
https://pubmed.ncbi.nlm.nih.gov/36512407
https://pubmed.ncbi.nlm.nih.gov/36512407
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) and β-cell destruction is mediated by proinflammatory cytokines, reactive oxygen species (ROS) , and immune cells. NADPH oxidase (NOX) -derived superoxide, a precursor for many ROS, regulate cell signaling, cellular differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245423d8b47aee94060426c32c497f48
https://doi.org/10.2337/db22-73-or
https://doi.org/10.2337/db22-73-or
Publikováno v:
Diabetes. 70
Coxsackievirus B3 (CVB3) infection promotes the activation of proinflammatory immune cells and is associated with triggering type 1 diabetes (T1D). We previously demonstrated that CVB3 infection of Non-Obese Diabetic (NOD) mice accelerates T1D, partl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cfebedbdf2d39352b2551895225cbf8
https://doi.org/10.2337/db21-110-or
https://doi.org/10.2337/db21-110-or
Autor:
Melissa S Jennings, Barbara J. Klocke, Keri M. Kemp, Hubert M. Tse, L.W. Duck, Craig L. Maynard, Casey D. Morrow, Charles O. Elson, Rachel Q Muir, Goo Lee, Ashley E. Landuyt, Samuel I. Blum
Publikováno v:
Proc Natl Acad Sci U S A
Genome-wide association studies have identified ICOSLG, which encodes the inducible costimulator ligand (ICOSLG or ICOSL) as a susceptibility locus for inflammatory bowel disease. ICOSL has been implicated in the enhancement of pattern recognition re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9f82c70c2fa683aacb9a6bd1a9e0d5
https://doi.org/10.1073/pnas.2018278118
https://doi.org/10.1073/pnas.2018278118
Publikováno v:
The Journal of Immunology. 208:103.06-103.06
Proinflammatory cytokines, reactive oxygen species (ROS), and T cells contribute to β-cell destruction in Type 1 diabetes (T1D). NADPH oxidase (NOX) generate superoxide, a precursor for a variety of ROS, regulate cell survival, differentiation, sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7e8673d1d1689de799b8aa21c873f1
https://doi.org/10.4049/jimmunol.208.supp.103.06
https://doi.org/10.4049/jimmunol.208.supp.103.06
Autor:
Hubert M. Tse, Samuel I. Blum
Publikováno v:
Microorganisms, Vol 8, Iss 993, p 993 (2020)
Microorganisms
Microorganisms
Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-mediated destruction of insulin-producing β-cells. The concordance rate for T1D in monozygotic twins is ≈30–50%, indicating that environmental factors also play a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb87d816db10c59f52b8ada646b6246
https://www.mdpi.com/2076-2607/8/7/993
https://www.mdpi.com/2076-2607/8/7/993
Publikováno v:
Diabetes. 69
Antiviral responses are associated with triggering type 1 diabetes (T1D) including the synthesis of reactive oxygen species, proinflammatory cytokines, and autoreactive T cell activation. We previously demonstrated that Coxsackievirus B3 (CVB3) infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4496e684bbb8e2c2c87062cddc713eab
https://doi.org/10.2337/db20-291-or
https://doi.org/10.2337/db20-291-or
Autor:
KaLia Burnette, Samuel I. Blum
Publikováno v:
Transplantation. 105:S66-S66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ed64e4f85c941e6f13aa46cc6f646e
https://doi.org/10.1097/01.tp.0000804692.89565.b5
https://doi.org/10.1097/01.tp.0000804692.89565.b5