Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Samuel I, Miller"'
Autor:
Alexander Eng, Hillary S. Hayden, Christopher E. Pope, Mitchell J. Brittnacher, Anh T. Vo, Eli J. Weiss, Kyle R. Hager, Daniel H. Leung, Sonya L. Heltshe, Daniel Raftery, Samuel I. Miller, Lucas R. Hoffman, Elhanan Borenstein
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Infants with cystic fibrosis (CF) suffer from gastrointestinal (GI) complications, including pancreatic insufficiency and intestinal inflammation, which have been associated with impaired nutrition and growth. Recent evidence iden
Externí odkaz:
https://doaj.org/article/69900369972c4aafab8be30c1ed91e63
Autor:
Daniel Mann, Junping Fan, Kamolrat Somboon, Daniel P. Farrell, Andrew Muenks, Svetomir B. Tzokov, Frank DiMaio, Syma Khalid, Samuel I. Miller, Julien R. C. Bergeron
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Daniel Mann et al. describe a higher-resolution structure of the maintenance of lipid asymmetry inner membrane complex (MlaBDEF) in the Gram-negative pathogen, Acinetobacter baumannii. With this improved structural map, the authors clarify the second
Externí odkaz:
https://doaj.org/article/85d066ee80af486582adf7e304e0d791
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrob
Externí odkaz:
https://doaj.org/article/37bede7359424917bc4367ca879c6ab8
Autor:
Stacey M Meeker, Kevin S Mears, Naseer Sangwan, Mitchell J Brittnacher, Eli J Weiss, Piper M Treuting, Nicholas Tolley, Christopher E Pope, Kyle R Hager, Anh T Vo, Jisun Paik, Charles W Frevert, Hillary S Hayden, Lucas R Hoffman, Samuel I Miller, Adeline M Hajjar
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008251 (2020)
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI inflammation and nutrient malabsorptio
Externí odkaz:
https://doaj.org/article/a071568799924354a179ea30319fdea7
Autor:
Anna M. Kolodziejek, Melissa A. Altura, Junping Fan, Erik M. Petersen, Matthew Cook, Peter S. Brzovic, Samuel I. Miller
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2147-2156.e5 (2019)
Summary: Intracellular Salmonella use a type III secretion system (TTSS) to translocate effector proteins across the phagosome membrane and thus promote vacuole membrane tubulation, resulting in intracellular survival. This work demonstrates that the
Externí odkaz:
https://doaj.org/article/b601ce380b8f420ea55a922f7f2a0a92
Autor:
Maria T. Nelson, Christopher E. Pope, Robyn L. Marsh, Daniel J. Wolter, Eli J. Weiss, Kyle R. Hager, Anh T. Vo, Mitchell J. Brittnacher, Matthew C. Radey, Hillary S. Hayden, Alexander Eng, Samuel I. Miller, Elhanan Borenstein, Lucas R. Hoffman
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2227-2240.e5 (2019)
Summary: Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses a
Externí odkaz:
https://doaj.org/article/aa353231eef24d6ba4bb9100acd19923
Autor:
Cassandra Kamischke, Junping Fan, Julien Bergeron, Hemantha D Kulasekara, Zachary D Dalebroux, Anika Burrell, Justin M Kollman, Samuel I Miller
Publikováno v:
eLife, Vol 8 (2019)
The outer membrane (OM) of Gram-negative bacteria serves as a selective permeability barrier that allows entry of essential nutrients while excluding toxic compounds, including antibiotics. The OM is asymmetric and contains an outer leaflet of lipopo
Externí odkaz:
https://doaj.org/article/3e878368b67745b59962862f6cdc5c94
Autor:
Xia Wu, Juan D. Chavez, Devin K. Schweppe, Chunxiang Zheng, Chad R. Weisbrod, Jimmy K. Eng, Ananya Murali, Samuel A. Lee, Elizabeth Ramage, Larry A. Gallagher, Hemantha D. Kulasekara, Mauna E. Edrozo, Cassandra N. Kamischke, Mitchell J. Brittnacher, Samuel I. Miller, Pradeep K. Singh, Colin Manoil, James E. Bruce
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of
Externí odkaz:
https://doaj.org/article/1333b90e086549de845305809266c010
Autor:
Samuel I Miller, Nina R Salama
Publikováno v:
PLoS Biology, Vol 16, Iss 1, p e2004935 (2018)
Gram-negative bacteria are surrounded by two membrane bilayers separated by a space termed the periplasm. The periplasm is a multipurpose compartment separate from the cytoplasm whose distinct reducing environment allows more efficient and diverse me
Externí odkaz:
https://doaj.org/article/257d8c56856f4749859beae73f8b74b3
Autor:
Adam Akullian, Joel M Montgomery, Grace John-Stewart, Samuel I Miller, Hillary S Hayden, Matthew C Radey, Kyle R Hager, Jennifer R Verani, John Benjamin Ochieng, Jane Juma, Jim Katieno, Barry Fields, Godfrey Bigogo, Allan Audi, Judd Walson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006156 (2018)
Non-typhoidal Salmonella (NTS) is a leading cause of bloodstream infections in Africa, but the various contributions of host susceptibility versus unique pathogen virulence factors are unclear. We used data from a population-based surveillance platfo
Externí odkaz:
https://doaj.org/article/cf26cca6195e420caaf020a250e173e2