Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Samuel Hofmann"'
Autor:
Samuel Hofmann, Julius Luther, Verena Plank, Andreas Oswald, Julia Mai, Ilka Simons, Julija Miller, Valeria Falcone, Lea Hansen-Palmus, Hartmut Hengel, Michael Nassal, Ulrike Protzer, Sabrina Schreiner
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTThe key to a curative treatment of hepatitis B virus (HBV) infection is the eradication of the intranuclear episomal covalently closed circular DNA (cccDNA), the stable persistence reservoir of HBV. Currently, established therapies can only l
Externí odkaz:
https://doaj.org/article/d213e4c1e51c4b75b24d1bab32c333e8
Publikováno v:
Viruses, Vol 16, Iss 4, p 633 (2024)
Differentiated HepaRG cells are popular in vitro cell models for hepatotoxicity studies. Their differentiation is usually supported by the addition of dimethyl sulfoxide (DMSO), an amphipathic solvent widely used in biomedicine, for example, in poten
Externí odkaz:
https://doaj.org/article/e1ac6d1d125e413b9a9fa39770f5ecaa
Autor:
Lilian Göttig, Christina Weiß, Miona Stubbe, Lisa Hanrieder, Samuel Hofmann, Alessandro Grodziecki, Daniela Stadler, Arnaud Carpentier, Ulrike Protzer, Sabrina Schreiner
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Apobec3A is involved in the antiviral host defense, targeting nuclear DNA, introducing point mutations, and thereby activating DNA damage response (DDR). Here, we found a significant upregulation of Apobec3A during HAdV infection, including
Externí odkaz:
https://doaj.org/article/834b7118c58c489b8a65f95c42d7bbe1
Autor:
Samuel Hofmann, Verena Plank, Peter Groitl, Nathalie Skvorc, Katharina Hofmann, Julius Luther, Chunkyu Ko, Peter Zimmerman, Volker Bruss, Daniela Stadler, Arnaud Carpentier, Shahinda Rezk, Michael Nassal, Ulrike Protzer, Sabrina Schreiner
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the ho
Externí odkaz:
https://doaj.org/article/6e91a524171e45ca9719ff6aadbb1c3c
Autor:
Miona Stubbe, Julia Mai, Christina Paulus, Hans Christian Stubbe, Julia Berscheminski, Maryam Karimi, Samuel Hofmann, Elisabeth Weber, Kamyar Hadian, Ron Hay, Peter Groitl, Michael Nevels, Thomas Dobner, Sabrina Schreiner
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Human adenoviruses (HAdVs) have developed mechanisms to manipulate cellular antiviral measures to ensure proper DNA replication, with detailed processes far from being understood. Host cells repress incoming viral genomes through a network o
Externí odkaz:
https://doaj.org/article/d784e1e6eba148b3a70d9bc1131bb912
Autor:
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack‐Werner, Sabrina Schreiner
Publikováno v:
Advanced Science, Vol 7, Iss 8, Pp n/a-n/a (2020)
Abstract Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis. In the absence of protective immunity, as in allogeneic bone marrow transplant patients, H
Externí odkaz:
https://doaj.org/article/965de59d17624f1788412f54eaf49a86
Autor:
Julia Mai, Miona Stubbe, Samuel Hofmann, Sawinee Masser, Thomas Dobner, Christopher Boutell, Peter Groitl, Sabrina Schreiner
Publikováno v:
Microbiol. Spectr. 10:e0078522 (2022)
Promyelocytic leukemia nuclear bodies (PML-NBs) were considered to maintain antiviral capacity, as these spherical complexes are antagonized by viruses. Actual work provides evidence, that PML-NB-associated factors might also be beneficial for distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373275d65215aa276f94f37cc96f37ac
https://eprints.gla.ac.uk/273885/1/273885.pdf
https://eprints.gla.ac.uk/273885/1/273885.pdf
Autor:
Alexander Muckenhuber, Dietrich A. Ruess, Maria Kutschke, Kivanc Görgülü, Samuel Hofmann, Rickmer Braren, Katrin J. Ciecielski, Derya Kabacaoglu, Martin Jastroch, Ezgi Kaya-Aksoy, Kalliope N. Diakopoulos, Alexandra Berninger, Hana Algül, Nan Wu, S Wörmann, Irina Heid, Mireia Vallespinós, Marc Riemann, Anna Melissa Schlitter, Roland M. Schmid, Marina Lesina, Ihsan Ekin Demir, Diego Navarro, Sladjana Zagorac, Güralp O. Ceyhan, Bruno Sainz, Marlena Kowalska, Jiaoyu Ai, Sabrina Schreiner, Katja Steiger, Sonia Alcalá, Julia Slotta-Huspenina
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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[Background & Aims]: The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47664f409b470bee4db55636c8f6b4e
https://doi.org/10.1053/j.gastro.2021.03.051
https://doi.org/10.1053/j.gastro.2021.03.051
Publikováno v:
Virus Research. 295:198280
PML nuclear bodies are matrix-bound nuclear structures with a variety of functions in human cells. These nuclear domains are interferon regulated and play an essential role during virus infections involving accumulation of SUMO-dependent host and vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645ea01ca34564734072325b16258088
https://doi.org/10.1016/j.virusres.2020.198280
https://doi.org/10.1016/j.virusres.2020.198280