Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samuel Hertig"'
Autor:
Scott A. Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A. J. Venkatakrishnan, Samuel Hertig, Peter J. Scammells, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Ron O. Dror
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Allosteric GPCR modulators can achieve exquisite subtype selectivity, but the underlying mechanism is unclear. Using molecular dynamics simulations, the authors here identify a previously undetected dynamic pocket in muscarinic GPCRs that is critical
Externí odkaz:
https://doaj.org/article/a0e90ef319f249dd8f9b3fd6b23a0233
Autor:
Simon Arnoldini, Alessandra Moscaroli, Mamta Chabria, Manuel Hilbert, Samuel Hertig, Roger Schibli, Martin Béhé, Viola Vogel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed
Externí odkaz:
https://doaj.org/article/8af98124e0cc41929238a7f5cc43757f
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 6, p e1004746 (2016)
Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein. By capt
Externí odkaz:
https://doaj.org/article/18a06cb1c466414485968ac15a18a6a1
Autor:
Samuel Hertig, Christian C. Felder, Patrick M. Sexton, Peter J. Scammells, Geoff Thompson, Scott A. Hollingsworth, Celine Valant, Brendan Kelly, Olivia Mastromihalis, AJ Venkatakrishnan, Ron O. Dror, Jordan Arthur Michaelis, Arthur Christopoulos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0be5dc7de5242a49ca0f055208cabd1
http://link.springer.com/article/10.1038/s41467-019-11062-7
http://link.springer.com/article/10.1038/s41467-019-11062-7
Autor:
Samuel Hertig, Graham T. Johnson
Publikováno v:
Nature Reviews Molecular Cell Biology. 15:690-698
To achieve effective visual communication of complex data, it is important that biologists identify the needs of their audience — whether they are peers or an outreach audience. This guide to the available wealth of resources, ranging from software
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9879bc2d5cb061bca4d89158e7712cf9
https://doi.org/10.1038/nrm3874
https://doi.org/10.1038/nrm3874
Autor:
Simon Arnoldini, Manuel Hilbert, Roger Schibli, Martin Béhé, Viola Vogel, Samuel Hertig, Alessandra Moscaroli, Mamta Chabria
Publikováno v:
Nature Communications
Nature Communications, 8 (1)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, 8 (1)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Transformations of extracellular matrix (ECM) accompany pathological tissue changes, yet how cell-ECM crosstalk drives these processes remains unknown as adequate tools to probe forces or mechanical strains in tissues are lacking. Here, we introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc855c4d71872f35a2ded72da8ac537
https://pubmed.ncbi.nlm.nih.gov/29176724
https://pubmed.ncbi.nlm.nih.gov/29176724
Autor:
Michel O. Steinmetz, Samuel Hertig, Jožica Dolenc, John Missimer, Jane R. Allison, Lorna J. Smith
NMR experiments provide detailed structural information about biological macromolecules in solution. However, the amount of information obtained is usually much less than the number of degrees of freedom of the macromolecule. Moreover, the relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572c04404d6e67e57a11765231f69fb8
https://ora.ox.ac.uk/objects/uuid:309f14b3-a0b9-4f87-9ba9-e4dee9a00b21
https://ora.ox.ac.uk/objects/uuid:309f14b3-a0b9-4f87-9ba9-e4dee9a00b21
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 6, p e1004746 (2016)
PLoS Computational Biology
PLoS Computational Biology
Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties of another site on the protein. By capt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41077c69eda89f80ce0a35ae9b86efc
http://europepmc.org/articles/PMC4902200?pdf=render
http://europepmc.org/articles/PMC4902200?pdf=render
Publikováno v:
Biophysical journal, vol 108, iss 9
Homology modeling predicts protein structures using known structures of related proteins as templates. We developed MULTIDOMAIN ASSEMBLER (MDA) to address the special problems that arise when modeling proteins with large numbers of domains, such as f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d2412950b9627bcd42f6271831065
https://pubmed.ncbi.nlm.nih.gov/25954868
https://pubmed.ncbi.nlm.nih.gov/25954868
Publikováno v:
NanoLetters.
Inspired by bacterial adhesins, we present a promising strategy of how to engineer peptides to probe various mechanical strains of extracellular matrix fibers. Functional sequence alignment of bacterial adhesins reveals that the bacterial linkers con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f5a3a195a31d10398df7dc5f5b0c1d