Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Samuel H Sternberg"'
Autor:
Kyle Stearns, George Lampe, Rachel Hanan, Tara Marcink, Stefan Niewiesk, Samuel H. Sternberg, Alexander L. Greninger, Matteo Porotto, Anne Moscona
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F). Receptor-engaged HN activates F to insert into the target cell membrane
Externí odkaz:
https://doaj.org/article/1b9b1509766f4952b1c50d056dda649c
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-8 (2021)
Abstract Bacterial transposons propagate through either non-replicative (cut-and-paste) or replicative (copy-and-paste) pathways, depending on how the mobile element is excised from its donor source. In the well-characterized E. coli transposon Tn7,
Externí odkaz:
https://doaj.org/article/e54c19eabf524f4b90e890ea807c520d
Publikováno v:
Nucleic Acids Research. 51:4519-4535
CRISPR-associated transposases (CASTs) direct DNA integration downstream of target sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas systems. Transposition relies on several key protein-protein and protein-DNA interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a2c397300bf985691ae1df81a64156
https://doi.org/10.1093/nar/gkad270
https://doi.org/10.1093/nar/gkad270
Autor:
Florian T. Hoffmann, Minjoo Kim, Leslie Y. Beh, Jing Wang, Phuc Leo H. Vo, Diego R. Gelsinger, Jerrin Thomas George, Christopher Acree, Jason T. Mohabir, Israel S. Fernández, Samuel H. Sternberg
Publikováno v:
Nature. 609:384-393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f672a117dfa2faea2b1d891856b74550
https://doi.org/10.1038/s41586-022-05059-4
https://doi.org/10.1038/s41586-022-05059-4
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
CRISPR-Cas9 has enabled an unprecedented ability to manipulate the genome yet it is still poorly understood how target recognition functions at a molecular level. Here the authors use single-molecule FRET to probe Cas9-target interaction and identify
Externí odkaz:
https://doaj.org/article/32ed29bb68544d38a4398de244550193
Autor:
George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez, Samuel H. Sternberg
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f5be4d30797441e7f22401a637dca6
https://doi.org/10.1038/s41587-023-01748-1
https://doi.org/10.1038/s41587-023-01748-1
Autor:
Diego R. Gelsinger, Phuc Leo H. Vo, Sanne E. Klompe, Carlotta Ronda, Harris Wang, Samuel H. Sternberg
Publikováno v:
bioRxiv
CRISPR-associated transposons (CASTs) have the potential to transform the technology landscape for kilobase-scale genome engineering, by virtue of their ability to integrate large genetic payloads with high accuracy, easy programmability, and no requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614f99902e87d153625df3e1e92083d2
https://europepmc.org/articles/PMC10055292/
https://europepmc.org/articles/PMC10055292/
Autor:
George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez, Samuel H. Sternberg
Publikováno v:
bioRxiv
Traditional genome-editing reagents such as CRISPR-Cas9 achieve targeted DNA modification by introducing double-strand breaks (DSBs), thereby stimulating localized DNA repair by endogenous cellular repair factors. While highly effective at generating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf336c5dfa340acb16ed7115aea378
https://europepmc.org/articles/PMC10055298/
https://europepmc.org/articles/PMC10055298/
Autor:
Chance Meers, Hoang Le, Sanjana R. Pesari, Florian T. Hoffmann, Matt W.G. Walker, Jeanine Gezelle, Samuel H. Sternberg
Publikováno v:
bioRxiv
Insertion sequences (IS) are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance. IS200/IS605elements undergo ‘peel-and-paste’ transposition catalyzed by a Tn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfbff12346c75ef2d14a777cdbd0e7b
https://europepmc.org/articles/PMC10055086/
https://europepmc.org/articles/PMC10055086/
CRISPR-associated transposons (CASTs) direct DNA integration downstream of target sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas systems. Transposition relies on several key protein-protein and protein-DNA interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3555acbf3f66a7f9145015afe4382c
https://doi.org/10.1101/2023.01.19.524723
https://doi.org/10.1101/2023.01.19.524723