Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Samuel H Speck"'
Autor:
Shuai Liu, Zhangmengxue Lei, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H Speck, Xiaozhen Liang
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008701 (2020)
Gammaherpesviruses have evolved various strategies to take advantage of host cellular factors or signaling pathways to establish a lifelong latent infection. Like the human gammaherpesvirus Epstein-Barr virus, murine gammaherpesvirus 68 (MHV68) estab
Externí odkaz:
https://doaj.org/article/4ab5229fee91453e81297371a9db358f
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008438 (2020)
One of the defining characteristics of the B cell receptor (BCR) is the extensive diversity in the repertoire of immunoglobulin genes that make up the BCR, resulting in broad range of specificity. Gammaherpesviruses are B lymphotropic viruses that es
Externí odkaz:
https://doaj.org/article/09b66100827c472e9c8dcee21a7fcde5
Autor:
Shariya Terrell, Samuel H Speck
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006543 (2017)
Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice has provided a tractable small animal model for dissecting gammaherpesvirus pathogenesis. The MHV68 latency associated antigen M2 promotes viral latency establishment in germi
Externí odkaz:
https://doaj.org/article/ac5c9a585c8a4d90926e8a415f4c2b86
Autor:
Caline G Matar, Neil R Anthony, Brigid M O'Flaherty, Nathan T Jacobs, Lalita Priyamvada, Christian R Engwerda, Samuel H Speck, Tracey J Lamb
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004858 (2015)
Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria. Multiple risk factors are
Externí odkaz:
https://doaj.org/article/651d93814d444d15a59ad9edbf5b1bb4
Autor:
Christopher M Collins, Samuel H Speck
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004831 (2015)
The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice also leads to life-long infection in
Externí odkaz:
https://doaj.org/article/b1c002199cda4d29baeafd540f78990a
Autor:
Brigid M O'Flaherty, Caline G Matar, Brian S Wakeman, AnaPatricia Garcia, Carol A Wilke, Cynthia L Courtney, Bethany B Moore, Samuel H Speck
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135719 (2015)
Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there is growing appreciation for the role of viral infection in disease induction and/or progres
Externí odkaz:
https://doaj.org/article/26e2f085e64b40dba44c54569fbf2304
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004302 (2014)
MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis. Having evolved with their natural host, herpesviruses encode numero
Externí odkaz:
https://doaj.org/article/9aada8f46fb94e8d864ef094d1bbf7bc
Autor:
Christopher M Collins, Samuel H Speck
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004106 (2014)
X linked lymphoproliferative disease (XLP) is an inherited immunodeficiency resulting from mutations in the gene encoding the slam associated protein (SAP). One of the defining characteristics of XLP is extreme susceptibility to infection with Epstei
Externí odkaz:
https://doaj.org/article/82f5bc6f885b4c23bcecc1c85d3e269d
Autor:
Udaya S Rangaswamy, Samuel H Speck
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003858 (2014)
Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. We have previously s
Externí odkaz:
https://doaj.org/article/0d3e061cd39b468abfda97ac36ead416
Autor:
Francine M Scott, Samuel H Speck
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93871 (2014)
Passage through the eukaryotic cell cycle is regulated by the activity of cyclins and their cyclin-dependent kinase partners. Rhadinoviruses, such as Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68), encode a vira
Externí odkaz:
https://doaj.org/article/ad86f472a32d45bca1a8339342cfb82a