Zobrazeno 1 - 10
of 518
pro vyhledávání: '"Samuel H, Wilson"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
DNA polymerase (pol) λ performs DNA synthesis in base excision and double strand break repair. How pol λ accomplishes nucleotide insertion that can lead to mutagenesis and genomic instability was unclear. Here the authors employ time-lapse crystall
Externí odkaz:
https://doaj.org/article/0259b8fb398f4a0e841fd706bae5546e
Autor:
Joonas A. Jamsen, Akira Sassa, Lalith Perera, David D. Shock, William A. Beard, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
Externí odkaz:
https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
How DNA polymerases discriminate against oxidized and undamaged nucleotides during DNA repair is not fully understood. Here, the authors reveal high-resolution timelapse X-ray crystallography snapshots of DSB repair polymerase μ undergoing DNA synth
Externí odkaz:
https://doaj.org/article/64968d1c0b29445aac6abe67bd0ccdd1
Publikováno v:
ACS Omega, Vol 5, Iss 25, Pp 15317-15324 (2020)
Externí odkaz:
https://doaj.org/article/0d610d077b2c4704b25c867d569d6658
Autor:
Gurushankar Chandramouly, Joonas Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L. Calbert, Taylor Tredinnick, Ahmet Y. Ozdemir, Tatiana Kent, Elena V. Demidova, Sanjeevani Arora, Samuel H. Wilson, Richard T. Pomerantz
Publikováno v:
Nature Structural & Molecular Biology. 30:107-114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb21037186bc209320ac1c1a1d235de
https://doi.org/10.1038/s41594-022-00895-4
https://doi.org/10.1038/s41594-022-00895-4
Autor:
Melike Çağlayan, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol
Externí odkaz:
https://doaj.org/article/9b91fd3a4ead491b98485dbc7c2bb67c
Autor:
Jason A Watts, Christopher Grunseich, Yesenia Rodriguez, Yaojuan Liu, Dongjun Li, Joshua T Burdick, Alan Bruzel, Robert J Crouch, Robert W Mahley, Samuel H Wilson, Vivian G Cheung
Publikováno v:
Nucleic Acids Res
RNA is modified by hundreds of chemical reactions and folds into innumerable shapes. However, the regulatory role of RNA sequence and structure and how dysregulation leads to diseases remain largely unknown. Here, we uncovered a mechanism where RNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34db6494b76e0b415e1f824b580bf63
https://doi.org/10.1093/nar/gkac1107
https://doi.org/10.1093/nar/gkac1107
Autor:
Joonas A. Jamsen, William A. Beard, Lars C. Pedersen, David D. Shock, Andrea F. Moon, Juno M. Krahn, Katarzyna Bebenek, Thomas A. Kunkel, Samuel H. Wilson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA polymerase (pol) μ functions in DNA double-strand break repair. Here the authors use time-lapse X-ray crystallography to capture the states of pol µ during the conversion from pre-catalytic to product complex and observe a third transiently bou
Externí odkaz:
https://doaj.org/article/982a48bce8204f249e81938b26845c43
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Oxidative stress in cells leads to the oxidations of DNA precursors. Here the authors show that these oxidized precursors can be incorporatedin vivoduring base excision repair, leading to DNA breaks and cytotoxicity.
Externí odkaz:
https://doaj.org/article/d2a81dca650b43be9b6e7c1748afddde
Autor:
Gurushankar Chandramouly, Joonas Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L. Calbert, Taylor Tredinnick, Ahmet Y. Ozdemir, Tatiana Kent, Elena V. Demidova, Sanjeevani Arora, Samuel H. Wilson, Richard T. Pomerantz
Publikováno v:
Nature Structural & Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::047bc3905d45fab3e75e44dff76c52d7
https://doi.org/10.1038/s41594-023-00993-x
https://doi.org/10.1038/s41594-023-00993-x