Methods to study folding of alpha-helical membrane proteins in lipids

Autor: Nicola J. Harris, Grant A. Pellowe, Laura R. Blackholly, Samuel Gulaidi-Breen, Heather E. Findlay, Paula J. Booth

Publikováno v: Open Biology, Vol 12, Iss 7 (2022)

How alpha-helical membrane proteins fold correctly in the highly hydrophobic membrane interior is not well understood. Their folding is known to be highly influenced by the lipids within the surrounding bilayer, but the majority of folding studies ha

Externí odkaz: https://doaj.org/article/7bd8e352c1df4d9da1a25ff881457634

How lipids affect the energetics of co-translational alpha helical membrane protein folding

Autor: Ryan Brady, Nicola J. Harris, Grant A. Pellowe, Samuel Gulaidi Breen, Paula J. Booth

Publikováno v: Brady, R, Harris, N J, Pellowe, G A, Breen, S G & Booth, P J 2022, ' How lipids affect the energetics of co-translational alpha helical membrane protein folding ', Biochemical Society Transactions, vol. 50, no. 1, pp. 555-567 . https://doi.org/10.1042/BST20201063

Membrane proteins need to fold with precision in order to function correctly, with misfolding potentially leading to disease. The proteins reside within a hydrophobic lipid membrane and must insert into the membrane and fold correctly, generally whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9ac00335d49ab088506bfa0c0bdf33
https://pubmed.ncbi.nlm.nih.gov/35212365