Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation

Autor: Henriette Edemann-Callesen, Le Dong, Mareike Voget, Helmut Kettenmann, Dilansu Guneykaya, Anais Djodari-Irani, Samuel G. Ewing, Regina Schweibold, Susanne A. Wolf, Lucia del-Valle-Anton, Ravit Hadar, Thomas Goetz, Christine Winter

Publikováno v: Brain, Behavior, and Immunity. 63:71-80

In recent years schizophrenia has been recognized as a neurodevelopmental disorder likely involving a perinatal insult progressively affecting brain development. The poly I:C maternal immune activation (MIA) rodent model is considered as a neurodevel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b20eef3d2553e9dc04ebad244c92227
https://doi.org/10.1016/j.bbi.2016.12.003

Evidence for impaired sound intensity processing during prepulse inhibition of the startle response in a rodent developmental disruption model of schizophrenia

Autor: Anthony A. Grace, Samuel G. Ewing

Publikováno v: Journal of Psychiatric Research. 47:1630-1635

A number of studies have implicated disruptions in prepulse inhibition (PPI) of the startle response in both schizophrenia patients and animal models of this disorder. These disruptions are believed to reflect deficits in sensorimotor gating and are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c5dee7a1600d97b0ba457bf63ceaf6
https://doi.org/10.1016/j.jpsychires.2013.07.012

The ventral portion of the CA1 region of the hippocampus and the prefrontal cortex as candidate regions for neuromodulation in schizophrenia

Autor: Christine Winter, Samuel G. Ewing

Publikováno v: Medical Hypotheses. 80:827-832

Existing antipsychotic drugs are most effective in the treatment of the positive symptoms of schizophrenia. However, they are associated with considerable side effects and have relatively low efficacy. Diminished inhibitory control in the hippocampus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77b2262c65a06c4ad0e26f97f5c33b1
https://doi.org/10.1016/j.mehy.2013.03.026

SaBer DBS: A fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation

Autor: John S. Riddell, Samuel G. Ewing, Anthony A. Grace, Bernd Porr, Christine Winter

Publikováno v: Journal of Neuroscience Methods. 213:228-235

To effectively study the mechanisms by which deep brain stimulation (DBS) produces its therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS over an extended period of time in awake, freely behaving animals. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b54b37f18725ae326e9d84519232e6
https://doi.org/10.1016/j.jneumeth.2012.12.008

Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia

Autor: Clement Hamani, Mareike Voget, Javier Pascau, Ravit Hadar, L Bikovski, Franziska Wieske, Samuel G. Ewing, Ina Weiner, María Luisa Soto-Montenegro, Manuel Desco, J Schimke, Thomas Götz, P Maier, Christine Winter

Publikováno v: e-Archivo: Repositorio Institucional de la Universidad Carlos III de Madrid
Universidad Carlos III de Madrid (UC3M)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
instname

The notion that schizophrenia is a neurodevelopmental disorder in which neuropathologies evolve gradually over the developmental course indicates a potential therapeutic window during which pathophysiological processes may be modified to halt disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f8faaed7523fee895504f900151c0
https://pubmed.ncbi.nlm.nih.gov/28373685