Výsledky vyhledávání - "Samuel G. Awuah"

Akademický článek

A gold-based inhibitor of oxidative phosphorylation is effective against triple negative breast cancer

Autor: R. Tyler Mertens, Jong Hyun Kim, Samuel Ofori, Chibuzor Olelewe, Paul J. Kamitsuka, Gunnar F. Kwakye, Samuel G. Awuah

Publikováno v: Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116010- (2024)

Triple-negative breast cancer (TNBC) is associated with metabolic heterogeneity and poor prognosis with limited treatment options. New treatment paradigms for TNBC remains an unmet need. Thus, therapeutics that target metabolism are particularly attr

Externí odkaz: https://doaj.org/article/7b0052f6d7a84bc88ec1ced1acc9d4e4

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Akademický článek

Synthetic Control of Mitochondrial Dynamics: Developing Three-Coordinate Au(I) Probes for Perturbation of Mitochondria Structure and Function

Autor: R. Tyler Mertens, William C. Jennings, Samuel Ofori, Jong Hyun Kim, Sean Parkin, Gunnar F. Kwakye, Samuel G. Awuah

Publikováno v: JACS Au, Vol 1, Iss 4, Pp 439-449 (2021)

Externí odkaz: https://doaj.org/article/7583f64a846141c7a744e17bbaa6b837

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Akademický článek

Gold(III)-P-chirogenic complex induces mitochondrial dysfunction in triple-negative breast cancer

Autor: Chibuzor Olelewe, Jong Hyun Kim, Samuel Ofori, Randall T. Mertens, Sailajah Gukathasan, Samuel G. Awuah

Publikováno v: iScience, Vol 25, Iss 5, Pp 104340- (2022)

Summary: Chemical agents that specifically exploit metabolic vulnerabilities of cancer cells will be beneficial but are rare. The role of oxidative phosphorylation (OXPHOS) in promoting and maintaining triple-negative breast cancer (TNBC) growth prov

Externí odkaz: https://doaj.org/article/352aa5f49ee648eda75194e12d86adcc

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Akademický článek

Synthesis and crystal structure of 1,3-bis(4-hydroxyphenyl)-1H-imidazol-3-ium chloride

Autor: R. Tyler Mertens, Sean R. Parkin, Samuel G. Awuah

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 9, Pp 1311-1315 (2019)

Imidazolium salts are common building blocks for functional materials and in the synthesis of N-heterocyclic carbene (NHC) as σ-donor ligands for stable metal complexes. The title salt, 1,3-bis(4-hydroxyphenyl)-1H-imidazol-3-ium chloride (IOH·Cl),

Externí odkaz: https://doaj.org/article/887ac28d64e0459c8744f69badb07d69

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Akademický článek

Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents

Autor: Jong Hyun Kim, Evan Reeder, Sean Parkin, Samuel G. Awuah

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)

Abstract The reaction of gold reagents [HAuCl4•3H2O], [AuCl(tht)], or cyclometalated gold(III) precursor, [C^NAuCl2] with chiral ((R,R)-(-)-2,3-bis(t-butylmethylphosphino) quinoxaline) and non-chiral phosphine (1,2-Bis(diphenylphosphino)ethane, dpp

Externí odkaz: https://doaj.org/article/c687d6da5dc54928aaad050c95cb7fde

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Akademický článek

Small-Molecule Poly(ADP-ribose) Polymerase and PD-L1 Inhibitor Conjugates as Dual-Action Anticancer Agents

Autor: Samuel Ofori, Samuel G. Awuah

Publikováno v: ACS Omega, Vol 4, Iss 7, Pp 12584-12597 (2019)

Externí odkaz: https://doaj.org/article/e5b4ddf8a9d74af0a27b5b3ae7d00c8f

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Akademický článek

Synthesis, Characterization, and Antiproliferative Activity of Novel Chiral [QuinoxP*AuCl2]+ Complexes

Autor: Adedamola S. Arojojoye, R. Tyler Mertens, Samuel Ofori, Sean R. Parkin, Samuel G. Awuah

Publikováno v: Molecules, Vol 25, Iss 23, p 5735 (2020)

Herein is reported the synthesis of two Au(III) complexes bearing the (R,R)-(–)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (R,R-QuinoxP*) or (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (S,S-QuinoxP*) ligands. By reacting two stoichio

Externí odkaz: https://doaj.org/article/4aff83a6ec954399af61bfec2a0e428f

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